PMID- 36572003
OWN - NLM
STAT- MEDLINE
DCOM- 20230712
LR  - 20230718
IS  - 1742-481X (Electronic)
IS  - 1742-4801 (Print)
IS  - 1742-4801 (Linking)
VI  - 20
IP  - 6
DP  - 2023 Aug
TI  - Fabrication of baicalein-encapsulated zeolitic imidazole framework as a novel 
      nanocomposited wound closure material to persuade pH-responsive healing efficacy 
      in post-caesarean section wound care.
PG  - 1921-1933
LID - 10.1111/iwj.14052 [doi]
AB  - Baicalein is a plant-derived compound, it has widespread attention among 
      biomedical researchers due to its biocompatibility and efficient biological 
      activities. But it has non-solubility in physiological conditions and short 
      bioavailability in the clinical process. The Discovery of a stimuli-based drug 
      delivery system (DDS) is a perfect strategy to improve the bioactivity of 
      baicalin in post-caesarean section wound care. We prepared a 
      baicalein-encapsulated pH-responsive DDS with a zeolite imidazole framework-8 
      (ZIF-8) as a carrier. We investigated the material characteristics of DDS in 
      terms of crystal structure, surface area morphology, particle size, FTIR, UV-vis, 
      Powder XRD, and BET analysis techniques. The in vitro cytotoxicity, 
      biocompatibility, and cell proliferation properties of BA@ZIF-8 were assessed 
      against human fibroblast L929 cells. In vitro studies showed that BA@ZIF-8 
      nanocomposite significantly enhanced the biocompatibility against L929 cells 
      after 72 h post-exposure. The pH-responsive drug release kinetics shows excellent 
      baicalein release under acidic conditions and without unwanted drug release in 
      physiological conditions. Wound scratch assay results revealed, that BA@ZIF-8 
      nanocomposite-treated cells exhibit the fastest cell proliferation and migration 
      process in a very short period. In the antibacterial activity study, 
      nanocomposite exposed dose depended on inhibition against wound infectious 
      pathogens. The overall study signifies that BA@ZIF-8 nano-DDSs are effective and 
      suitable DDS for stimuli-based post-caesarean section wound care.
CI  - (c) 2022 The Authors. International Wound Journal published by Medicalhelplines.com 
      Inc (3M) and John Wiley & Sons Ltd.
FAU - Yang, Jing
AU  - Yang J
AD  - Obstetrics and Gynecology, Ningbo Women and Children's Hospital, Ningbo, China.
FAU - Chen, Aner
AU  - Chen A
AD  - Obstetrics and Gynecology, Ningbo Women and Children's Hospital, Ningbo, China.
FAU - He, Xiaobo
AU  - He X
AD  - Obstetrics and Gynecology, Ningbo Women and Children's Hospital, Ningbo, China.
FAU - Lu, Shuangji
AU  - Lu S
AUID- ORCID: 0000-0001-5307-0596
AD  - Obstetrics and Gynecology, Ningbo Women and Children's Hospital, Ningbo, China.
LA  - eng
GR  - 2010-S04/the Co-construction of Medical Support Key Construction Disciplines of 
      Ningbo, China/
PT  - Journal Article
DEP - 20221226
PL  - England
TA  - Int Wound J
JT  - International wound journal
JID - 101230907
RN  - 1318-02-1 (Zeolites)
RN  - 49QAH60606 (baicalein)
RN  - 0 (Imidazoles)
SB  - IM
MH  - Female
MH  - Pregnancy
MH  - Humans
MH  - *Zeolites/therapeutic use/chemistry
MH  - Cesarean Section
MH  - Imidazoles/therapeutic use/chemistry
MH  - Hydrogen-Ion Concentration
PMC - PMC10333042
OTO - NOTNLM
OT  - antimicrobial
OT  - baicalein
OT  - caesarean section
OT  - cell migration
OT  - toxicity
OT  - wound care
COIS- The authors declare no conflicts of interest.
EDAT- 2022/12/27 06:00
MHDA- 2023/07/12 06:42
PMCR- 2022/12/26
CRDT- 2022/12/26 18:17
PHST- 2022/12/01 00:00 [revised]
PHST- 2022/10/14 00:00 [received]
PHST- 2022/12/04 00:00 [accepted]
PHST- 2023/07/12 06:42 [medline]
PHST- 2022/12/27 06:00 [pubmed]
PHST- 2022/12/26 18:17 [entrez]
PHST- 2022/12/26 00:00 [pmc-release]
AID - IWJ14052 [pii]
AID - 10.1111/iwj.14052 [doi]
PST - ppublish
SO  - Int Wound J. 2023 Aug;20(6):1921-1933. doi: 10.1111/iwj.14052. Epub 2022 Dec 26.