PMID- 365740
OWN - NLM
STAT- MEDLINE
DCOM- 19790313
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 22
IP  - 1
DP  - 1978 Oct
TI  - Inhibition of the secretory activity of Escherichia coli heat-stable enterotoxin 
      by indomethacin.
PG  - 143-7
AB  - The effect of indomethacin on the net intestinal accumulation of fluid induced by 
      Escherichia coli heat-stable (ST) enterotoxin in the infant mouse model was 
      examined. Indomethacin, when administered with ST enterotoxin, caused a striking 
      decrease in net intestinal fluid accumulation. This inhibition of ST activity was 
      dose dependent with various concentrations of indomethacin (P less than 0.01). A 
      significant inhibition of toxicity was also observed when indomethacin was given 
      before (P less than 0.01) or after (P less than 0.02) ST enterotoxin challenge. 
      No significant differences in fluid accumulation were observed between control 
      mice treated with buffer alone and those challenged with only indomethacin. These 
      data indicate that indomethacin markedly decreases the net intestinal fluid 
      accumulation induced by E. coli ST enterotoxin. Further studies on the potential 
      use of indomethacin in both the prophylaxis and the therapy of diarrheal diseases 
      appear warranted.
FAU - Madsen, G L
AU  - Madsen GL
FAU - Knoop, F C
AU  - Knoop FC
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Bacterial Toxins)
RN  - 0 (Enterotoxins)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Animals
MH  - Bacterial Toxins/*antagonists & inhibitors
MH  - Biological Assay
MH  - Body Water/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Enterotoxins/*antagonists & inhibitors
MH  - *Escherichia coli
MH  - Indomethacin/*pharmacology
MH  - Intestinal Mucosa/metabolism
MH  - Mice
PMC - PMC422128
EDAT- 1978/10/01 00:00
MHDA- 1978/10/01 00:01
PMCR- 1978/10/01
CRDT- 1978/10/01 00:00
PHST- 1978/10/01 00:00 [pubmed]
PHST- 1978/10/01 00:01 [medline]
PHST- 1978/10/01 00:00 [entrez]
PHST- 1978/10/01 00:00 [pmc-release]
AID - 10.1128/iai.22.1.143-147.1978 [doi]
PST - ppublish
SO  - Infect Immun. 1978 Oct;22(1):143-7. doi: 10.1128/iai.22.1.143-147.1978.