PMID- 36575048
OWN - NLM
STAT- MEDLINE
DCOM- 20230109
LR  - 20240227
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 14
IP  - 24
DP  - 2022 Dec 27
TI  - Exosomes derived from human umbilical cord mesenchymal stem cells promote 
      osteogenesis through the AKT signaling pathway in postmenopausal osteoporosis.
PG  - 10125-10136
LID - 10.18632/aging.204453 [doi]
AB  - Postmenopausal osteoporosis (PMO) is a relatively common disease characterized by 
      low bone mass and microstructural changes of trabecular bone. The reduced bone 
      strength is caused a variety of complications, including fragility fracture and 
      sarcopenia. We used CCK-8 and EdU assays to evaluate cell proliferation rates. 
      The osteogenesis effect was detected using ALP staining, alizarin red staining, 
      and q-PCR. In vivo, the effects of exosomes derived from HUC-MSCs were evaluated 
      using HE staining, IHC staining and Masson staining. In addition, we explored the 
      mechanism of exosomes and found that the AKT signaling pathway played an 
      important role in osteogenesis and cell proliferation. This paper mainly explored 
      the function of exosomes derived from human umbilical cord mesenchymal stem cells 
      (HUC-MSCs) and provided a new strategy for the treatment of postmenopausal 
      osteoporosis. In conclusion, exogenous administration of exosomes can contribute 
      to the treatment postmenopausal osteoporosis to a certain extent.
FAU - Ren, Shi-Wei
AU  - Ren SW
AD  - Department of Orthopedics, The Provincial Hospital Affiliated to Shandong First 
      Medical University, Jinan 250014, Shandong, China.
FAU - Cao, Guang-Qing
AU  - Cao GQ
AD  - Department of Spine Surgery, The Second Hospital, Cheeloo College of Medicine, 
      Shandong University, Jinan 250033, Shandong, China.
FAU - Zhu, Qing-Run
AU  - Zhu QR
AD  - Department of Orthopedics, The Provincial Hospital Affiliated to Shandong First 
      Medical University, Jinan 250014, Shandong, China.
FAU - He, Min-Gang
AU  - He MG
AD  - Department of Gastrointestinal Surgery, Shandong Tumor Hospital and Institute, 
      Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 
      250117, Shandong, China.
FAU - Wu, Fang
AU  - Wu F
AD  - Department of Health, 960th Hospital of PLA, Jinan 250031, Shandong, China.
FAU - Kong, Su-Mei
AU  - Kong SM
AD  - Department of Health, 960th Hospital of PLA, Jinan 250031, Shandong, China.
FAU - Zhang, Zhao-Yan
AU  - Zhang ZY
AD  - Department of Health, 960th Hospital of PLA, Jinan 250031, Shandong, China.
FAU - Wang, Qiang
AU  - Wang Q
AD  - Department of Orthopedics, The Provincial Hospital Affiliated to Shandong First 
      Medical University, Jinan 250014, Shandong, China.
FAU - Wang, Feng
AU  - Wang F
AD  - Department of Orthopedics, The Provincial Hospital Affiliated to Shandong First 
      Medical University, Jinan 250014, Shandong, China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20221227
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
RIN - Aging (Albany NY). 2023 Dec 14;15(23):14506. PMID: 38097356
MH  - Humans
MH  - Female
MH  - Osteogenesis
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - *Osteoporosis, Postmenopausal/therapy/metabolism
MH  - *Exosomes/metabolism
MH  - Signal Transduction
MH  - *Mesenchymal Stem Cells/metabolism
MH  - Umbilical Cord/metabolism
PMC - PMC9831744
OTO - NOTNLM
OT  - exosomes
OT  - human umbilical cord mesenchymal stem cells
OT  - osteogenesis
OT  - postmenopausal osteoporosis
COIS- CONFLICTS OF INTEREST: The authors declare that they have no known conflicts of 
      interest or personal relationships that could have influenced the work reported 
      in this paper.
EDAT- 2022/12/28 06:00
MHDA- 2023/01/10 06:00
PMCR- 2022/12/31
CRDT- 2022/12/27 21:12
PHST- 2022/05/06 00:00 [received]
PHST- 2022/12/16 00:00 [accepted]
PHST- 2022/12/28 06:00 [pubmed]
PHST- 2023/01/10 06:00 [medline]
PHST- 2022/12/27 21:12 [entrez]
PHST- 2022/12/31 00:00 [pmc-release]
AID - 204453 [pii]
AID - 10.18632/aging.204453 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2022 Dec 27;14(24):10125-10136. doi: 10.18632/aging.204453. 
      Epub 2022 Dec 27.