PMID- 36575477 OWN - NLM STAT- MEDLINE DCOM- 20221229 LR - 20230522 IS - 1470-7330 (Electronic) IS - 1740-5025 (Print) IS - 1470-7330 (Linking) VI - 22 IP - 1 DP - 2022 Dec 27 TI - Whole body FDG PET/MR for progression free and overall survival prediction in patients with relapsed/refractory large B-cell lymphomas undergoing CAR T-cell therapy. PG - 76 LID - 10.1186/s40644-022-00513-y [doi] LID - 76 AB - BACKGROUND: To find semi-quantitative and quantitative Positron Emission Tomography/Magnetic Resonance (PET/MR) imaging metrics of both tumor and non-malignant lymphoid tissue (bone marrow and spleen) for Progression Free Survival (PFS) and Overall Survival (OS) prediction in patients with relapsed/refractory (r/r) large B-cell lymphoma (LBCL) undergoing Chimeric Antigen Receptor (CAR) T-cell therapy. METHODS: A single-center prospective study of 16 r/r LBCL patients undergoing CD19-targeted CAR T-cell therapy. Whole body 18F-fluorodeoxyglucose (FDG) PET/MR imaging pre-therapy and 3 weeks post-therapy were followed by manual segmentation of tumors and lymphoid tissues. Semi-quantitative and quantitative metrics were extracted, and the metric-wise rate of change (Delta) between post-therapy and pre-therapy calculated. Tumor metrics included maximum Standardized Uptake Value (SUV(max)), mean SUV (SUV(mean)), Metabolic Tumor Volume (MTV), Tumor Lesion Glycolysis (TLG), structural volume (V), total structural tumor burden (V(total)) and mean Apparent Diffusion Coefficient (ADC(mean)). For lymphoid tissues, metrics extracted were SUV(mean), mean Fat Fraction (FF(mean)) and ADC(mean) for bone marrow, and SUV(mean), V and ADC(mean) for spleen. Univariate Cox regression analysis tested the relationship between extracted metrics and PFS and OS. Survival curves were produced using Kaplan-Meier analysis and compared using the log-rank test, with the median used for dichotomization. Uncorrected p-values < 0.05 were considered statistically significant. Correction for multiple comparisons was performed, with a False Discovery Rate (FDR) < 0.05 considered statistically significant. RESULTS: Pre-therapy (p < 0.05, FDR < 0.05) and Delta (p < 0.05, FDR > 0.05) total tumor burden structural and metabolic metrics were associated with PFS and/or OS. According to Kaplan-Meier analysis, a longer PFS was reached for patients with pre-therapy MTV 0.05), while DeltaADC(mean) was associated with both PFS and OS (p < 0.05, FDR > 0.05). DeltaADC(mean) > 0.92 gave longer PFS and OS in the Kaplan-Meier analysis. Pre-therapy bone marrow SUV(mean) was associated with PFS (p < 0.05, FDR < 0.05) and OS (p < 0.05, FDR > 0.05). For bone marrow FDG uptake, patient stratification was possible pre-therapy (SUV(mean)