PMID- 36575541
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230103
IS  - 2055-0928 (Electronic)
IS  - 2055-0928 (Linking)
VI  - 8
IP  - 1
DP  - 2022 Dec 27
TI  - Effect of a diet based on the dietary guidelines for americans on inflammation 
      markers in women at risk for cardiometabolic disease: results of a randomized, 
      controlled trial.
PG  - 157
LID - 10.1186/s40795-022-00647-z [doi]
LID - 157
AB  - OBJECTIVE: To evaluate the effect of a diet pattern based on Dietary Guidelines 
      for Americans (DGA), in a controlled feeding setting, on plasma markers of 
      inflammation and on cytokine production by peripheral blood mononuclear cells 
      (PBMC). DESIGN: Women (n = 44) with one or more risk factors of metabolic 
      syndrome (and BMI: 25.2-39.8 kg/m(2)) completed an 8-wk controlled feeding study. 
      They were randomized to either a group following a diet based on DGA 2010 (DGA), 
      or a group given a 'typical American diet' (TAD), based largely on a Western diet 
      pattern. By design, women maintained their body weight. Fasting plasma and PBMC 
      were collected at wk. 0 (baseline) and at wk. 8 (post-intervention). Sixteen 
      plasma markers of inflammation and eight PBMC cytokines were measured at both 
      time points, to evaluate if the diet had a significant effect on concentrations 
      of these inflammatory markers. Data were analyzed using ANCOVA, followed by 
      multiple-comparison adjustment using Benjamini-Hochberg method. RESULTS: 
      Significant changes observed in Serum Amyloid A (SAA) and Matrix 
      Metalloproteinase 3 (MMP3) in plasma did not retain significance upon multiple 
      comparison adjustment. SAA: p = 0.044, adj p = 0.450; DGA mean change [95% 
      CI] = - 12.6[- 32.3 to 7.04]; TAD mean change [95% CI] = - 2.24 [- 9.99 to 5.51]. 
      MMP3: p = 0.014, adj p = 0.35; DGA mean change [95% CI] = 2.72[- 4.16 to 9.59]; 
      TAD mean change [95% CI] = - 0.98[- 16.7 to 14.7]). Other inflammation markers 
      were not differently altered by DGA relative to TAD. Effect size of change 
      (Cohens d) indicated a large/medium-large effect of intervention on MMP3 and CRP, 
      and medium effect on IL-6. CONCLUSIONS: No statistically significant changes were 
      observed in the immune markers examined in this study. The biological roles and 
      magnitude of the non-significant differences seen with two variables, CRP and 
      MMP3, suggest that they be examined in future studies. TRIAL REGISTRATION: 
      Clinicaltrials.gov identifier NCT02298725.
CI  - (c) 2022. This is a U.S. Government work and not under copyright protection in the 
      US; foreign copyright protection may apply.
FAU - Krishnan, Sridevi
AU  - Krishnan S
AD  - Department of Nutrition, University of California Davis, Davis, CA, USA.
AD  - Obesity and Metabolism Unit, USDA-WHNRC, Davis, CA, USA.
AD  - Department of Pediatrics, School of Medicine, University of California San Diego, 
      San Diego, CA, USA.
FAU - Freytag, Tammy
AU  - Freytag T
AD  - Bioanalytical Support Laboratory, USDA-WHNRC, Davis, CA, USA.
FAU - Jiang, Xiaowen
AU  - Jiang X
AD  - Immunology and Disease Prevention Unit, USDA-WHNRC, Davis, CA, USA.
FAU - Schuster, Gertrud U
AU  - Schuster GU
AD  - Department of Nutrition, University of California Davis, Davis, CA, USA.
AD  - Immunology and Disease Prevention Unit, USDA-WHNRC, Davis, CA, USA.
FAU - Woodhouse, Leslie R
AU  - Woodhouse LR
AD  - Bioanalytical Support Laboratory, USDA-WHNRC, Davis, CA, USA.
FAU - Keim, Nancy L
AU  - Keim NL
AD  - Department of Nutrition, University of California Davis, Davis, CA, USA.
AD  - Obesity and Metabolism Unit, USDA-WHNRC, Davis, CA, USA.
FAU - Stephensen, Charles B
AU  - Stephensen CB
AD  - Department of Nutrition, University of California Davis, Davis, CA, USA. 
      charles.stephensen@ars.usda.gov.
AD  - Immunology and Disease Prevention Unit, USDA-WHNRC, Davis, CA, USA. 
      charles.stephensen@ars.usda.gov.
LA  - eng
SI  - ClinicalTrials.gov/NCT02298725
PT  - Journal Article
DEP - 20221227
PL  - England
TA  - BMC Nutr
JT  - BMC nutrition
JID - 101672434
PMC - PMC9793666
OTO - NOTNLM
OT  - C-reactive protein
OT  - Dietary guidelines for americans
OT  - Matrix metalloproteinase-3
COIS- None to report
EDAT- 2022/12/28 06:00
MHDA- 2022/12/28 06:01
PMCR- 2022/12/27
CRDT- 2022/12/27 23:51
PHST- 2022/03/28 00:00 [received]
PHST- 2022/12/02 00:00 [accepted]
PHST- 2022/12/27 23:51 [entrez]
PHST- 2022/12/28 06:00 [pubmed]
PHST- 2022/12/28 06:01 [medline]
PHST- 2022/12/27 00:00 [pmc-release]
AID - 10.1186/s40795-022-00647-z [pii]
AID - 647 [pii]
AID - 10.1186/s40795-022-00647-z [doi]
PST - epublish
SO  - BMC Nutr. 2022 Dec 27;8(1):157. doi: 10.1186/s40795-022-00647-z.