PMID- 36576067
OWN - NLM
STAT- MEDLINE
DCOM- 20231121
LR  - 20231121
IS  - 1478-6427 (Electronic)
IS  - 1478-6419 (Linking)
VI  - 37
IP  - 23
DP  - 2023 Nov-Dec
TI  - Antiplasmodial and antimicrobial activities of ent-abietane diterpenoids from the 
      roots of Suregada zanzibariensis.
PG  - 4008-4012
LID - 10.1080/14786419.2022.2158463 [doi]
AB  - The root extract of Suregada zanzibariensis Baill. afforded six previously 
      described ent-abietane diterpenoids, namely 
      7-oxo-ent-abieta-5(6),8(14),13(15)-trien-16,12-olide (1), mangiolide (2), 
      8,14beta:11,12alpha-diepoxy-13(15)-abietane-16,12-olide (3), 
      7beta,11beta,12beta-trihydroxy-ent-abieta-8(14),13(15)-diene-16,12-olide (4), 
      8alpha,14-dihydro-7-oxo-jolkinolide E (5), jolkinolide A (6), together with 
      3beta-sitosterol (7), scopoletin (8) and vanillin (9). Their structures were deduced 
      through 1D and 2D NMR spectroscopic techniques, and HRESIMS, as well as by 
      comparison of the NMR data with those reported in the literature. The crude 
      extract and compounds 1-9 were evaluated for their antiplasmodial, antifungal and 
      antibacterial activities. Mangiolide (2) showed strong in vitro antiplasmodial 
      activity against chloroquine sensitive (D6) and resistant (W2) strains of 
      Plasmodium falciparum with IC(50) values of 0.79 and 0.87 microg/mL, respectively, 
      while 3 (IC(50) 1.24 and 1.17 microg/mL) was less active than 2. Compound 2 also 
      displayed antimicrobial activity against Cryptococcus neoformans, 
      methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant 
      Enterococcus faecium (VRE) with IC(50) values of 1.20, 3.90 and 7.20 microg/mL, 
      respectively.
FAU - Obegi Matundura, Jackson
AU  - Obegi Matundura J
AD  - Department of Chemistry, University of Nairobi, Nairobi, Kenya.
FAU - Midiwo, Jacob O
AU  - Midiwo JO
AD  - Department of Chemistry, University of Nairobi, Nairobi, Kenya.
FAU - Yenesew, Abiy
AU  - Yenesew A
AD  - Department of Chemistry, University of Nairobi, Nairobi, Kenya.
FAU - Omosa, Leonidah K
AU  - Omosa LK
AD  - Department of Chemistry, University of Nairobi, Nairobi, Kenya.
FAU - Kumarihamy, Mallika
AU  - Kumarihamy M
AD  - National Centre for Natural Products Research, Research Institute of 
      Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, 
      University, Mississippi, 38677, USA.
FAU - Zhao, Jianping
AU  - Zhao J
AD  - National Centre for Natural Products Research, Research Institute of 
      Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, 
      University, Mississippi, 38677, USA.
FAU - Wang, Mei
AU  - Wang M
AD  - National Centre for Natural Products Research, Research Institute of 
      Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, 
      University, Mississippi, 38677, USA.
AD  - Natural Products Utilization Research Unit, Agricultural Research Service, United 
      States, Department of Agriculture, University, Mississippi, 38677, USA.
FAU - Tripathi, Siddharth
AU  - Tripathi S
AD  - National Centre for Natural Products Research, Research Institute of 
      Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, 
      University, Mississippi, 38677, USA.
FAU - Khan, Shabana
AU  - Khan S
AD  - National Centre for Natural Products Research, Research Institute of 
      Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, 
      University, Mississippi, 38677, USA.
FAU - Masila, Veronica M
AU  - Masila VM
AD  - Department of Chemistry, University of Nairobi, Nairobi, Kenya.
FAU - Nchiozem-Ngnitedem, Vaderament-A
AU  - Nchiozem-Ngnitedem VA
AUID- ORCID: 0000-0001-8337-9260
AD  - Department of Chemistry, University of Nairobi, Nairobi, Kenya.
FAU - Muhammad, Ilias
AU  - Muhammad I
AD  - National Centre for Natural Products Research, Research Institute of 
      Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, 
      University, Mississippi, 38677, USA.
LA  - eng
PT  - Journal Article
DEP - 20221228
PL  - England
TA  - Nat Prod Res
JT  - Natural product research
JID - 101167924
RN  - 0 (Abietanes)
RN  - 0 (Antimalarials)
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Abietanes
MH  - *Antimalarials/pharmacology
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - *Suregada
MH  - Anti-Bacterial Agents/pharmacology
OTO - NOTNLM
OT  - Euphorbiaceae
OT  - Suregada zanzibariensis
OT  - antibacterial activities
OT  - antifungal
OT  - antiplasmodial
OT  - diterpenoid lactone
EDAT- 2022/12/29 06:00
MHDA- 2023/11/21 06:42
CRDT- 2022/12/28 06:13
PHST- 2023/11/21 06:42 [medline]
PHST- 2022/12/29 06:00 [pubmed]
PHST- 2022/12/28 06:13 [entrez]
AID - 10.1080/14786419.2022.2158463 [doi]
PST - ppublish
SO  - Nat Prod Res. 2023 Nov-Dec;37(23):4008-4012. doi: 10.1080/14786419.2022.2158463. 
      Epub 2022 Dec 28.