PMID- 36576409
OWN - NLM
STAT- MEDLINE
DCOM- 20230302
LR  - 20230302
IS  - 1366-5804 (Electronic)
IS  - 1354-750X (Linking)
VI  - 28
IP  - 2
DP  - 2023 Mar
TI  - Psidium cattleianum fruit extract prevents systemic alterations in an animal 
      model of type 2 diabetes mellitus: comparison with metformin effects.
PG  - 238-248
LID - 10.1080/1354750X.2022.2163695 [doi]
AB  - Objective: In this study, we aimed to determine the role of Psidium cattleianum 
      extract (PCE) and compare its effects with those of metformin (Met) in an animal 
      model with type 2 diabetes mellitus (T2DM).Methods: T2DM was induced in rats 
      using a high-fat diet (HFD), followed by a single dose of streptozotocin (STZ). 
      Met and PCE were administered intragastrically once a day throughout the 
      experiment, and their effects on biochemical, inflammatory, oxidative, and 
      histological parameters were evaluated.Results: Met and PCE prevented the 
      increase in serum levels of glucose, total cholesterol (TC), triacylglycerol 
      (TG), very low-density lipoprotein (VLDL) and interleukin-6 (IL-6) induced by 
      T2DM, and restored redox homeostasis in the liver and brain. Met increased the 
      serum levels of anti-inflammatory cytokine and interleukin-10 (IL-10). 
      Furthermore, both treatments restored the liver and pancreas from marked cellular 
      disorganisation, vacuolisation, and necrosis, with PCE being more effective than 
      Met in recovering histological changes.Conclusion: PCE is a promising agent for 
      the prevention of T2DM complications.
FAU - Cardoso, Juliane De Souza
AU  - Cardoso JS
AUID- ORCID: 0000-0002-2726-4159
AD  - Laboratorio de Biomarcadores, Centro de Ciencias Quimicas, Farmaceuticas e de 
      Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil.
FAU - Cardoso Teixeira, Fernanda
AU  - Cardoso Teixeira F
AD  - Laboratorio de Neuroquimica, Inflamacao e Cancer, Centro de Ciencias Quimicas, 
      Farmaceuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil.
FAU - De Mello, Julia Eisenhardt
AU  - De Mello JE
AD  - Laboratorio de Neuroquimica, Inflamacao e Cancer, Centro de Ciencias Quimicas, 
      Farmaceuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil.
FAU - Soares De Aguiar, Mayara Sandrielly
AU  - Soares De Aguiar MS
AD  - Laboratorio de Neuroquimica, Inflamacao e Cancer, Centro de Ciencias Quimicas, 
      Farmaceuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil.
FAU - Souto Oliveira, Pathise
AU  - Souto Oliveira P
AUID- ORCID: 0000-0002-8321-7402
AD  - Faculdade de Nutricao, Universidade Federal de Pelotas, Pelotas, Brazil.
FAU - Torchelsen Saraiva, Juliane
AU  - Torchelsen Saraiva J
AD  - Laboratorio de Biomarcadores, Centro de Ciencias Quimicas, Farmaceuticas e de 
      Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil.
FAU - Vizzotto, Marcia
AU  - Vizzotto M
AD  - Empresa Brasileira de Pesquisa Agropecuaria, Centro de Pesquisa Agropecuaria de 
      Clima Temperado, Pelotas, Brazil.
FAU - Borelli Grecco, Fabiane
AU  - Borelli Grecco F
AD  - Laboratorio de Patologia Animal, Programa de Pos-Graduacao em Veterinaria, 
      Universidade Federal de Pelotas, Pelotas, Brazil.
FAU - Lencina, Claiton Leoneti
AU  - Lencina CL
AD  - Laboratorio de Biomarcadores, Centro de Ciencias Quimicas, Farmaceuticas e de 
      Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil.
FAU - Spanevello, Roselia Maria
AU  - Spanevello RM
AD  - Faculdade de Nutricao, Universidade Federal de Pelotas, Pelotas, Brazil.
FAU - Tavares, Rejane Giacomelli
AU  - Tavares RG
AD  - Laboratorio de Biomarcadores, Centro de Ciencias Quimicas, Farmaceuticas e de 
      Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil.
AD  - Centro de Investigacao em Biociencias e Tecnologias da Saude (CBIOS), 
      Universidade Lusofona de Humanidades e Tecnologias, Lisboa, Portugal.
FAU - Stefanello, Francieli Moro
AU  - Stefanello FM
AUID- ORCID: 0000-0001-5945-3723
AD  - Laboratorio de Biomarcadores, Centro de Ciencias Quimicas, Farmaceuticas e de 
      Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20230104
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Animals
MH  - Rats
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Experimental/drug therapy/pathology
MH  - *Diabetes Mellitus, Type 2/drug therapy/pathology
MH  - Fruit
MH  - Hypoglycemic Agents/pharmacology
MH  - *Metformin/pharmacology/therapeutic use
MH  - Models, Animal
MH  - *Psidium
OTO - NOTNLM
OT  - Diabetes
OT  - animal model
OT  - metformin
OT  - oxidative stress
OT  - phenolic compounds
EDAT- 2022/12/29 06:00
MHDA- 2023/03/03 06:00
CRDT- 2022/12/28 10:03
PHST- 2022/12/29 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2022/12/28 10:03 [entrez]
AID - 10.1080/1354750X.2022.2163695 [doi]
PST - ppublish
SO  - Biomarkers. 2023 Mar;28(2):238-248. doi: 10.1080/1354750X.2022.2163695. Epub 2023 
      Jan 4.