PMID- 36576463
OWN - NLM
STAT- MEDLINE
DCOM- 20221230
LR  - 20230103
IS  - 2282-4197 (Electronic)
IS  - 1124-3562 (Linking)
VI  - 94
IP  - 4
DP  - 2022 Dec 27
TI  - Urinary epidermal growth factor and monocyte chemotactic protein-1 as biomarkers 
      of renal injury in patients with obstructed nephropathy.
PG  - 443-446
LID - 10.4081/aiua.2022.4.443 [doi]
AB  - OBJECTIVE: To evaluate the role of urinary Monocyte Chemotactic Protein-1 (MCP1) 
      and urinary epidermal growth factor (EGF) in diagnosing of upper urinary tract 
      obstruction (UUTO). PATIENT AND METHODS: Over a period of 6 months (January 2022 
      to June 2022) this prospective case control comparative study was conducted on 
      120 participants, 60 of them with UUTO and 60 healthy controls. A morning urine 
      sample of all participants was tested for EGF and MCP-1. after taking a detailed 
      history taking and laboratory and radiological evaluation. RESULTS: Urinary 
      MCP-1(uMCP-1) was significantly (p-value = 0.000) increased in UUTO group showing 
      a mean +/- SD of 518.10 +/- 51.19 ng/L compared to a mean +/- SD of 143.32 +/- 58.03 ng/L 
      in the controls, whereas a significantly (p-value = 0.000) decrease of urinary 
      EGF (uEGF) was observed in patients with UUTO compared to control group. A 
      significant difference of uEGF level and uEGF/uMCP1 ratio was observed between 
      mild compared to moderate/severe UUTO. CONCLUSIONS: Utilization of the urinary 
      biomarker MCP1, EGF and uEGF/uMCP1 ratio in patients with UUTO can adequately be 
      used as a simple, efficacious and noninvasive way in diagnosis of UUTO.
FAU - El-Dydamony, Eman M
AU  - El-Dydamony EM
AD  - Department of Urology, Faculty of Medicine (for Girls), Al-Azhar University, 
      Cairo. Emanmohamed.8@azhar.edu.eg.
FAU - Abdelaal, Mohamed Ahmad
AU  - Abdelaal MA
AD  - Department of Urology, Faculty of Medicine (for Girls), Al-Azhar University, 
      Cairo. maal_uro@yahoo.com.
FAU - Kasim, Sammar Ahmad
AU  - Kasim SA
AD  - Department of Internal medicine, Faculty of Medicine (for Girls), Al-Azhar 
      University, Cairo. emanmohamed.8@azhar.edu.eg.
FAU - Ameen, Doaa Refaat
AU  - Ameen DR
AD  - Department of Biochemistry, Faculty of Medicine (for Girls), Al-Azhar University, 
      Cairo. emanmohamed.8@azhar.edu.eg.
FAU - El-Fattah, Doaa Aly Abd
AU  - El-Fattah DAA
AD  - Department of Clinical Pathology, Faculty of Medicine (for Girls), Al-Azhar 
      University, Cairo. emanmohamed.8@azhar.edu.eg.
LA  - eng
PT  - Journal Article
DEP - 20221227
PL  - Italy
TA  - Arch Ital Urol Androl
JT  - Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa 
      italiana di ecografia urologica e nefrologica
JID - 9308247
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - *Epidermal Growth Factor/metabolism
MH  - Chemokine CCL2/urine
MH  - Kidney
MH  - *Kidney Diseases
MH  - Biomarkers/urine
EDAT- 2022/12/29 06:00
MHDA- 2022/12/31 06:00
CRDT- 2022/12/28 10:33
PHST- 2022/10/27 00:00 [received]
PHST- 2022/11/12 00:00 [accepted]
PHST- 2022/12/28 10:33 [entrez]
PHST- 2022/12/29 06:00 [pubmed]
PHST- 2022/12/31 06:00 [medline]
AID - 10.4081/aiua.2022.4.443 [doi]
PST - epublish
SO  - Arch Ital Urol Androl. 2022 Dec 27;94(4):443-446. doi: 10.4081/aiua.2022.4.443.