PMID- 36577987 OWN - NLM STAT- MEDLINE DCOM- 20221230 LR - 20230317 IS - 1471-2415 (Electronic) IS - 1471-2415 (Linking) VI - 22 IP - 1 DP - 2022 Dec 28 TI - Detecting eyes with high risk of angle closure among apparently normal eyes by anterior segment OCT: a health examination center-based model. PG - 513 LID - 10.1186/s12886-022-02739-7 [doi] LID - 513 AB - BACKGROUND: The main barriers keeping individuals with high-risk of angle closure from seeking eye-care service are the absence of both disease awareness and convenient and low-cost access to the ocular health care system. Present study described the efficacy of a health examination center-based screening model designed to detect eyes with high risk of angle closure (HRAC) among healthy individuals using anterior segment optical coherence tomography (AS-OCT). METHODS: From March 1 to April 30, 2017, consecutive individuals aged >/= 40 years undergoing routine physical examinations at a health examination center were invited to enroll. Presenting visual acuity (PVA), intraocular pressure (IOP) measurement, non-mydriatic fundus photography and AS-OCT were performed by three trained nurses. Participants with PVA < 6/12 in the better-seeing eye, IOP >/= 24 mmHg, or abnormal fundus photography in either eye were referred to the outpatient clinic, but not included in the analysis. Eyes with HRAC were defined as having trabecular-iris angle < 12 degrees in >/= 3 quadrants. Configuration of the iris was classified into flat, bowing, bombe, thick peripheral iris and mixed mechanism. RESULTS: Altogether, 991 participants (77.3%) with readable OCT images (mean age 55.5 +/- 9.0 years; 58.4% men) were included. HRAC was diagnosed in 78 eyes (7.9%, 61.3 +/- 8.2 years, 41.0% men). The prevalence of HRAC increased with age (p < 0.001) and was much higher among women (11.2%) than men (5.5%) (p = 0.001). The mixed mechanism iris configuration was most common among eyes with HRAC (37/78, 47.4%). CONCLUSION: HRAC is prevalent among asymptomatic Chinese adults undergoing routine health screening. Health examination center-based eye screening with AS-OCT administered by non-specialists may be a good model to screen narrow angles in the population at large. CI - (c) 2022. The Author(s). FAU - Lin, Sigeng AU - Lin S AD - The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China. AD - Glaucoma Research Institute, Wenzhou Medical University, Wenzhou, China. AD - National Clinical Research Center for Ocular Diseases, Wenzhou, China. FAU - Hu, Ying AU - Hu Y AD - Department of Ophthalmology, The Forth People's Hospital of Shenyang, Huanggu District, NO. 20 Huanghenan Street, Shenyang, 110031, Liaoning, China. FAU - Ye, Cong AU - Ye C AD - The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China. AD - Glaucoma Research Institute, Wenzhou Medical University, Wenzhou, China. AD - National Clinical Research Center for Ocular Diseases, Wenzhou, China. FAU - Congdon, Nathan AU - Congdon N AD - Centre for Public Health, Queen's University Belfast, Belfast, UK. AD - Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. AD - Orbis International, New York, NY, USA. FAU - You, Ruirong AU - You R AD - The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China. AD - Glaucoma Research Institute, Wenzhou Medical University, Wenzhou, China. AD - National Clinical Research Center for Ocular Diseases, Wenzhou, China. FAU - Liu, Shanshan AU - Liu S AD - Department of Ophthalmology, The Forth People's Hospital of Shenyang, Huanggu District, NO. 20 Huanghenan Street, Shenyang, 110031, Liaoning, China. FAU - Liu, Chi AU - Liu C AD - Department of Ophthalmology, The Forth People's Hospital of Shenyang, Huanggu District, NO. 20 Huanghenan Street, Shenyang, 110031, Liaoning, China. Liuchi812@126.com. FAU - Lv, Fan AU - Lv F AD - The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China. AD - Glaucoma Research Institute, Wenzhou Medical University, Wenzhou, China. AD - National Clinical Research Center for Ocular Diseases, Wenzhou, China. FAU - Zhang, Shaodan AU - Zhang S AD - The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China. shaodan_zhang@eye.ac.cn. AD - Glaucoma Research Institute, Wenzhou Medical University, Wenzhou, China. shaodan_zhang@eye.ac.cn. AD - National Clinical Research Center for Ocular Diseases, Wenzhou, China. shaodan_zhang@eye.ac.cn. LA - eng GR - 2020YFC2008200/the National Key R&D Program of China/ GR - 2020YFC2008200/the National Key R&D Program of China/ GR - Y20190695/the Basic Scientific Research Program of Wenzhou/ GR - YNZD2201903/the Key Innovation and Guidance Program of the Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University/ GR - KYQD20180306/the Scientific Research Foundation of the Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University/ PT - Journal Article DEP - 20221228 PL - England TA - BMC Ophthalmol JT - BMC ophthalmology JID - 100967802 SB - IM EIN - BMC Ophthalmol. 2023 Mar 13;23(1):95. PMID: 36927325 MH - Male MH - Adult MH - Humans MH - Female MH - Middle Aged MH - *Tomography, Optical Coherence/methods MH - Intraocular Pressure MH - *Glaucoma, Angle-Closure/diagnosis MH - Gonioscopy MH - Iris/diagnostic imaging MH - Anterior Eye Segment/diagnostic imaging PMC - PMC9798562 OTO - NOTNLM OT - Anterior segment OCT OT - Health examination center OT - Narrow angle OT - Screening COIS- No competing interests exists for any author. EDAT- 2022/12/29 06:00 MHDA- 2022/12/31 06:00 PMCR- 2022/12/28 CRDT- 2022/12/28 23:41 PHST- 2022/09/01 00:00 [received] PHST- 2022/12/14 00:00 [accepted] PHST- 2022/12/28 23:41 [entrez] PHST- 2022/12/29 06:00 [pubmed] PHST- 2022/12/31 06:00 [medline] PHST- 2022/12/28 00:00 [pmc-release] AID - 10.1186/s12886-022-02739-7 [pii] AID - 2739 [pii] AID - 10.1186/s12886-022-02739-7 [doi] PST - epublish SO - BMC Ophthalmol. 2022 Dec 28;22(1):513. doi: 10.1186/s12886-022-02739-7.