PMID- 36578308
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230103
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 13
DP  - 2022
TI  - Altered functional hubs and connectivity in type 2 diabetes mellitus with and 
      without mild cognitive impairment.
PG  - 1062816
LID - 10.3389/fneur.2022.1062816 [doi]
LID - 1062816
AB  - Cognitive impairment in type 2 diabetes mellitus (T2DM) is associated with 
      functional and structural abnormalities of brain networks, especially the damage 
      to hub nodes in networks. This study explored the abnormal hub nodes of brain 
      functional networks in patients with T2DM under different cognitive states. 
      Sixty-five patients with T2DM and 34 healthy controls (HCs) underwent 
      neuropsychological assessment. Then, degree centrality (DC) analysis and 
      seed-based functional connectivity (FC) analysis were performed to identify the 
      abnormal hub nodes and the FC patterns of these hubs in T2DM patients with mild 
      cognitive impairment (MCI) (DMCI group, N = 31) and without MCI (DMCN group, N = 
      34). Correlation analyzes examined the relationship between abnormal DC and FC 
      and clinical/cognitive variables. Compared with HCs, both T2DM groups showed 
      decreased DC values in the visual cortex, and the T2DM patients with MCI (DMCI) 
      showed more extensive alterations in the right parahippocampal gyrus (PHG), 
      bilateral posterior cingulate cortex (PCC), and left superior frontal gyrus (SFG) 
      regions than T2DM patients with normal cognitive function. Seed-based FC analysis 
      of PHG and PCC nodes showed that functional disconnection mainly occurred in 
      visual and memory connectivity in patients with DMCI. Multiple abnormal DC values 
      correlated with neuropsychological tests in patients with T2DM. In conclusion, 
      this study found that the DMCI group displayed more extensive alterations in hub 
      nodes and FC in vision and memory-related brain regions, suggesting that 
      visual-related regions dysfunctions and disconnection may be involved in the 
      neuropathology of visuospatial function impairment in patients with DMCI.
CI  - Copyright (c) 2022 Huang, Zhang, Zhang, Cheng, Yang, Gao, Tang, Ai, Lei and Zhang.
FAU - Huang, Yang
AU  - Huang Y
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Zhang, Dongsheng
AU  - Zhang D
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Zhang, Xin
AU  - Zhang X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Cheng, Miao
AU  - Cheng M
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Yang, Zhen
AU  - Yang Z
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Gao, Jie
AU  - Gao J
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Tang, Min
AU  - Tang M
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Ai, Kai
AU  - Ai K
AD  - Department of Clinical and Technical Support, Philips Healthcare, Xi'an, China.
FAU - Lei, Xiaoyan
AU  - Lei X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Zhang, Xiaoling
AU  - Zhang X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
LA  - eng
PT  - Journal Article
DEP - 20221212
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC9792165
OTO - NOTNLM
OT  - degree centrality
OT  - functional connectivity
OT  - neuroimaging
OT  - resting-state functional magnetic resonance imaging
OT  - type 2 diabetes mellitus
COIS- Author KA was employed by company Philips Healthcare. The remaining authors 
      declare that the research was conducted in the absence of any commercial or 
      financial relationships that could be construed as a potential conflict of 
      interest.
EDAT- 2022/12/30 06:00
MHDA- 2022/12/30 06:01
PMCR- 2022/12/12
CRDT- 2022/12/29 02:16
PHST- 2022/10/06 00:00 [received]
PHST- 2022/11/21 00:00 [accepted]
PHST- 2022/12/29 02:16 [entrez]
PHST- 2022/12/30 06:00 [pubmed]
PHST- 2022/12/30 06:01 [medline]
PHST- 2022/12/12 00:00 [pmc-release]
AID - 10.3389/fneur.2022.1062816 [doi]
PST - epublish
SO  - Front Neurol. 2022 Dec 12;13:1062816. doi: 10.3389/fneur.2022.1062816. 
      eCollection 2022.