PMID- 36578988
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230103
IS  - 1300-0667 (Print)
IS  - 1309-4866 (Electronic)
IS  - 1300-0667 (Linking)
VI  - 59
IP  - Suppl 1
DP  - 2022
TI  - Importance of Pericytes in the Pathophysiology of Cerebral Ischemia.
PG  - S29-S35
LID - 10.29399/npa.28171 [doi]
AB  - Various cell types contribute to pathological changes observed in the brain 
      following cerebral ischemia. Pericytes, as a component of neurovascular unit 
      (NVU) and blood brain barrier (BBB), play a key role for cerebral blood flow 
      control and regulation of vessel permeability. It was shown that pericytes can 
      control cerebral blood flow at the level of capillaries, by their contractile 
      property. Their role in BBB development and maintenance are crucial for guidance 
      of brain vessel development, new vessel formation and stabilization of the newly 
      formed vessels. Additionally, they can contribute to inflammation in response to 
      inflammatory stimuli and can differentiate to various cell types by their 
      multipotent differentiation properties. This cell type which is intimately 
      associated with cerebral circulation also plays important roles during cerebral 
      ischemia. Here, we review the properties and physiological functions of 
      pericytes, how these functions change during ischemia to affect the 
      pathophysiology of ischemic stroke and post stroke cognitive impairment. 
      Pericytes are a neglected cell type and they are not unambiguously characterized 
      which in turn led to contradictory findings in the literature. Clear 
      characterization of pericytes by current methods will help better understanding 
      of their role in the pathophysiology of stroke. With the information gained from 
      these efforts it will be possible to develop pericyte specific therapeutic 
      targets and achieve important breakthroughs in clinical recovery in ischemic 
      stroke treatment.
CI  - Copyright: (c) 2022 Turkish Neuropsychiatric Society.
FAU - Gurler, Gokce
AU  - Gurler G
AD  - Hacettepe University, Institute of Neurological Sciences and Psychiatry, Ankara, 
      Turkey.
FAU - Soylu, Kadir Oguzhan
AU  - Soylu KO
AD  - Hacettepe University, Institute of Neurological Sciences and Psychiatry, Ankara, 
      Turkey.
FAU - Yemisci, Muge
AU  - Yemisci M
AD  - Hacettepe University, Institute of Neurological Sciences and Psychiatry, Ankara, 
      Turkey.
AD  - Hacettepe University, Faculty of Medicine, Department of Neurology, Ankara, 
      Turkey.
AD  - Neuroscience and Neurotechnology Center of Excellence (NOROM), Ankara, Turkey.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221216
PL  - Turkey
TA  - Noro Psikiyatr Ars
JT  - Noro psikiyatri arsivi
JID - 9426194
PMC - PMC9767130
OTO - NOTNLM
OT  - Blood brain barrier
OT  - brain ischemia
OT  - cognitive dysfunction
OT  - ischemic stroke
OT  - neurovascular unit
OT  - pericytes
COIS- Conflict of Interest: The authors declared that there is no conflict of interest.
EDAT- 2022/12/30 06:00
MHDA- 2022/12/30 06:01
PMCR- 2022/12/16
CRDT- 2022/12/29 02:42
PHST- 2022/03/19 00:00 [received]
PHST- 2022/04/02 00:00 [accepted]
PHST- 2022/12/29 02:42 [entrez]
PHST- 2022/12/30 06:00 [pubmed]
PHST- 2022/12/30 06:01 [medline]
PHST- 2022/12/16 00:00 [pmc-release]
AID - archneuro-59-S29 [pii]
AID - 10.29399/npa.28171 [doi]
PST - epublish
SO  - Noro Psikiyatr Ars. 2022 Dec 16;59(Suppl 1):S29-S35. doi: 10.29399/npa.28171. 
      eCollection 2022.