PMID- 36579215
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230103
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 11
DP  - 2022 Nov
TI  - Features of Kidney Function in Patients With Comorbidity of Arterial Hypertension 
      and Chronic Obstructive Pulmonary Disease.
PG  - e31828
LID - 10.7759/cureus.31828 [doi]
LID - e31828
AB  - Background and objective Chronic kidney disease (CKD) and hypertension are 
      closely linked in terms of cause and effect. Decreased renal function is usually 
      associated with increased blood pressure, and a steady increase in blood pressure 
      accelerates the decline in renal function. In this study, we aimed to investigate 
      laboratory parameters of renal function - blood creatinine level, urine 
      creatinine level, urea blood level, urine albumin level, and in particular, serum 
      cystatin C level - as early predictors of kidney damage and assess the filtration 
      function of the kidneys based on the glomerular filtration rate (GFR) in patients 
      with isolated arterial hypertension, those with a comorbid pathology of 
      hypertension and chronic obstructive pulmonary disease (COPD). and those with 
      isolated COPD. Materials and methods The study included a total of 101 patients 
      (the final sample consisted of 88 patients) with hypertension and COPD, who were 
      divided into three groups: Group I consisted of 38 patients with hypertension, 
      Group II comprised 27 patients with hypertension and COPD, and Group III was made 
      up of 23 patients with COPD. The average age of patients in groups - presented as 
      mean [standard deviation (SD)] - was as follows - Group I: 55.7 (11.2) years, 
      Group II: 59.3 (9.2) years, and Group III: 57.8 (9.1) years. For statistical data 
      processing, the program Statistics 10 was used. Results The level of blood 
      creatinine - presented as median (Me) and interquartile range (IQR) - was 
      statistically significantly different between the groups, and the values in the 
      three groups were as follows - Group I (patients with hypertension): 88.3 (84.2; 
      102.7) mumol/l, Group II (patients with comorbid pathology of arterial 
      hypertension and COPD): 99.0 (80.0; 115.0) mumol/l, and Group III (patients with 
      COPD): 84.6 (75.0; 94.2) mumol/l (p=0.008). The highest level was determined in 
      patients with hypertension and comorbid COPD, while the lowest was in the 
      comparison group, in patients with COPD. Urinary creatinine levels were as 
      follows - Group I: 1081.0 (578.0; 1749.0) mg/l, Group II: 1318.5 (1124.0; 1817.0) 
      mg/l, and Group III: 822.0 (625.0; 1320.5) mg/l (p=0.08). Blood urea values were 
      as follows - Group I: 5.7 (5.2; 6.0) mmol/l, Group II: 5.7 (4.9; 6.6) mmol/l, 
      Group III: 5.9 (4.4; 7.7) mmol/l. The calculation of GFR revealed a statistically 
      significant difference between the three groups - Group I: 70.5 (56.0; 83.0) 
      ml/min, Group II: 66.5 (57.0; 77.0) ml/min, and Group III: 81.5 (70.0; 88.0) 
      ml/min (p=0.02). The cystatin C level was 1.16 (1.03; 1.27) mg/l in Group I, 1.3 
      (1.22; 1.38) mg/l in Group II, and 1.05 (0.96; 1.05) mg/l in Group III. 
      Conclusions In patients of all three groups, there was a decrease in renal 
      filtration function based on the results of creatinine and cystatin C levels. 
      Even in the group of patients with COPD without kidney disease, a decrease in GFR 
      was observed. We noted a negative aggravating effect of COPD on renal function in 
      patients with hypertension, which can be attributed to increased endothelial 
      dysfunction and increased general inflammation in this group of patients.
CI  - Copyright (c) 2022, Boiko et al.
FAU - Boiko, Olha
AU  - Boiko O
AD  - Occupational Diseases, Clinical Immunology and Clinical Pharmacology, Dnipro 
      State Medical University, Dnipro, UKR.
FAU - Rodionova, Viktoriia
AU  - Rodionova V
AD  - Occupational Diseases, Clinical Immunology and Clinical Pharmacology, Dnipro 
      State Medical University, Dnipro, UKR.
FAU - Shevchenko, Luydmyla
AU  - Shevchenko L
AD  - Department of Physical, Organic and Inorganic Chemistry, Oles Honchar Dnipro 
      National University, Dnipro, UKR.
LA  - eng
PT  - Journal Article
DEP - 20221123
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9787688
OTO - NOTNLM
OT  - chronic obstructive pulmonary disease
OT  - cystatin c
OT  - glomerular filtration rate
OT  - hypertension
OT  - renal function
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/12/30 06:00
MHDA- 2022/12/30 06:01
PMCR- 2022/11/23
CRDT- 2022/12/29 02:49
PHST- 2022/11/23 00:00 [accepted]
PHST- 2022/12/29 02:49 [entrez]
PHST- 2022/12/30 06:00 [pubmed]
PHST- 2022/12/30 06:01 [medline]
PHST- 2022/11/23 00:00 [pmc-release]
AID - 10.7759/cureus.31828 [doi]
PST - epublish
SO  - Cureus. 2022 Nov 23;14(11):e31828. doi: 10.7759/cureus.31828. eCollection 2022 
      Nov.