PMID- 36579718 OWN - NLM STAT- MEDLINE DCOM- 20230306 LR - 20230321 IS - 1520-7560 (Electronic) IS - 1520-7552 (Linking) VI - 39 IP - 3 DP - 2023 Mar TI - Statin use in patients with type 2 diabetes has lower risk of hip fractures: A Taiwan national population-based study. PG - e3603 LID - 10.1002/dmrr.3603 [doi] AB - AIMS: Type 2 diabetes mellitus (T2DM) frequently co-exists with osteoporosis and dyslipidemia. Statins have been commonly used in the treatment of dyslipidemia. Recent studies have indicated a therapeutic role of statins in decreasing the risk of osteoporosis and fractures, but conflicting results have been reported. This study investigated the association between statin use and hip fracture (HFx) risk among T2DM patients. MATERIALS AND METHODS: A retrospective Taiwan population-based propensity-matched cohort study was performed using the Diabetes Mellitus Health Database from Taiwan National Health Insurance Research Database. Patients with newly diagnosed with T2DM between 2010 and 2014 were identified. Patients who previously used statins and had ever suffered HFx before the index date were excluded. HFx that occurred from 2010 to 2019 was collected to compute the cumulative rate of HFx. Hazard ratios (HRs) were calculated for the HFx risk according to the use or non-use of statins. To evaluate the dose-effect relationship of statins, sensitivity analyses were conducted. RESULTS: After propensity score matching for age and sex, 188,588 patients were identified as statin users and non-statin users. Statin use after T2DM diagnosis was associated with a decreased HFx risk with an adjusted HR (aHR) of 0.69 (P < 0.001). A dose-effect relationship was identified. The aHRs for developing HFx were 1.29, 0.67, and 0.36 for patients who used 28-174, 175-447, and >447 cumulative defined daily doses of statins, respectively (P < 0.001). CONCLUSIONS: Statin use in adults with T2DM showed a lower risk of HFx by demonstrating a dose-response relationship. CI - (c) 2022 John Wiley & Sons Ltd. FAU - Lee, Tien-Ching AU - Lee TC AUID- ORCID: 0000-0002-1510-8079 AD - Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Chen, Jian-Chih AU - Chen JC AD - Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Lin, Sung-Yen AU - Lin SY AD - Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Ho, Pei-Shan AU - Ho PS AD - Faculty of Dental Hygiene, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Chen, Chung-Hwan AU - Chen CH AD - Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan. FAU - Fu, Yin-Chih AU - Fu YC AD - Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan. FAU - Chang, Je-Ken AU - Chang JK AD - Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Ho, Mei-Ling AU - Ho ML AD - Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. AD - Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230125 PL - England TA - Diabetes Metab Res Rev JT - Diabetes/metabolism research and reviews JID - 100883450 RN - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) SB - IM MH - Adult MH - Humans MH - *Diabetes Mellitus, Type 2/complications/drug therapy/chemically induced MH - Retrospective Studies MH - Cohort Studies MH - *Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use MH - Taiwan/epidemiology MH - *Osteoporosis/chemically induced/complications/drug therapy MH - *Dyslipidemias/complications/drug therapy/epidemiology MH - *Hip Fractures/epidemiology/etiology/prevention & control MH - Risk Factors OTO - NOTNLM OT - dyslipidemia OT - hip fracture OT - osteoporosis OT - statin OT - type 2 diabetes EDAT- 2022/12/30 06:00 MHDA- 2023/03/07 06:00 CRDT- 2022/12/29 06:12 PHST- 2022/11/15 00:00 [revised] PHST- 2022/09/14 00:00 [received] PHST- 2022/12/14 00:00 [accepted] PHST- 2022/12/30 06:00 [pubmed] PHST- 2023/03/07 06:00 [medline] PHST- 2022/12/29 06:12 [entrez] AID - 10.1002/dmrr.3603 [doi] PST - ppublish SO - Diabetes Metab Res Rev. 2023 Mar;39(3):e3603. doi: 10.1002/dmrr.3603. Epub 2023 Jan 25.