PMID- 36580558
OWN - NLM
STAT- MEDLINE
DCOM- 20230102
LR  - 20230420
IS  - 1468-2834 (Electronic)
IS  - 0002-0729 (Print)
IS  - 0002-0729 (Linking)
VI  - 51
IP  - 12
DP  - 2022 Dec 5
TI  - Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail 
      cognitively impaired community-dwelling older adults: secondary analysis of a 
      multicentre randomised clinical trial.
LID - 10.1093/ageing/afac303 [doi]
LID - afac303
AB  - INTRODUCTION: The World Health Organisation recently defined the construct of 
      intrinsic capacity (IC), a function-based marker of older adult's health 
      encompassing all mental and physical capacities of the individual. Multicomponent 
      physical exercise (MCE) is a potential intervention capable to maintain/increase 
      IC at older age; however, evidence is scarce on the effects of MCE on IC in 
      cognitively impaired pre-frail/frail older adults. METHODS: Secondary analyses of 
      a randomised clinical trial. One hundred and eighty-eight older outpatients (age 
      = 84.06 +/- 4.77, 70.2% women) presenting with pre-frailty/frailty (according to 
      Fried Criteria) and mild cognitive impairment (MCI)/mild dementia were recruited 
      in the Geriatric clinics of three tertiary hospitals in Spain. Subjects were 
      randomised to participate in the 12-week home-based individualised Vivifrail MCE 
      or usual care. An IC index was created based on the z-score of the locomotion 
      (Short Physical Performance Battery), cognitive (Montreal Cognitive Assessment), 
      psychology (15-item Geriatric Depression Scale Yesavage) and vitality (handgrip 
      strength) domains. RESULTS: After the 3-month intervention, linear mixed models 
      showed significant between-group differences in the evolution of the IC composite 
      score (beta=0.48; 95% confidence interval [CI] = 0.24, 0.74; P < 0.001), IC 
      Locomotion (beta = 0.42; 95% CI = 0.10, 0.74; P < 0.001), IC Cognition (beta = 0.45; 
      95% CI = 0.03, 0.87; P < 0.05) and IC Vitality domains (beta = 0.50; 95% CI = 0.25, 
      0.74 at 3-month) favouring the MCE group. CONCLUSIONS: The 12-week Vivifrail 
      multicomponent exercise program is an effective strategy to enhance IC, 
      especially in terms of locomotion, cognition and vitality IC domains in 
      community-dwelling older adults with pre-frailty/frailty and MCI/mild dementia, 
      compared to usual care.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      British Geriatrics Society. All rights reserved. For permissions, please email: 
      journals.permissions@oup.com.
FAU - Sanchez-Sanchez, Juan Luis
AU  - Sanchez-Sanchez JL
AUID- ORCID: 0000-0002-2507-6015
AD  - Gerontopole de Toulouse, Institut du Vieillissement, Centre Hospitalier 
      Universitaire de Toulouse, 31000 Toulouse, France.
AD  - MOVE-IT Research Group, Department of Physical Education, Faculty of Education 
      Sciences, University of Cadiz, 11519 Cadiz, Spain.
AD  - Universidad Publica de Navarra (UPNA), Pamplona, Spain.
FAU - de Souto Barreto, Philipe
AU  - de Souto Barreto P
AD  - Gerontopole de Toulouse, Institut du Vieillissement, Centre Hospitalier 
      Universitaire de Toulouse, 31000 Toulouse, France.
AD  - CERPOP, Inserm 1295, Universite de Toulouse, UPS, Toulouse, France.
FAU - Anton-Rodrigo, Ivan
AU  - Anton-Rodrigo I
AD  - Hospital of Eibar, OSI Debabarrena, Osakidetza, Eibar, Gipuzkoa, Spain.
AD  - Grupo de Investigacion en Atencion Primaria, Biodonostia Institute of Health 
      Research, San Sebastian, Gipuzkoa, Spain.
FAU - Ramon-Espinoza, Fernanda
AU  - Ramon-Espinoza F
AD  - Functional Recovery Unit, Hospital San Juan de Dios, Pamplona, Spain.
FAU - Marin-Epelde, Itxaso
AU  - Marin-Epelde I
AD  - Geriatric Department, Hospital Universitario de Navarra (HUN), Pamplona, Spain.
FAU - Sanchez-Latorre, Marina
AU  - Sanchez-Latorre M
AD  - Geriatric Department, Hospital Universitario de Navarra (HUN), Pamplona, Spain.
FAU - Moral-Cuesta, Debora
AU  - Moral-Cuesta D
AD  - Geriatric Department, Hospital Universitario de Navarra (HUN), Pamplona, Spain.
FAU - Casas-Herrero, Alvaro
AU  - Casas-Herrero A
AD  - Geriatric Department, Hospital Universitario de Navarra (HUN), Pamplona, Spain.
AD  - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de 
      Navarra (UPNA), IdiSNA, Pamplona, Spain.
AD  - CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 
      Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Age Ageing
JT  - Age and ageing
JID - 0375655
SB  - IM
EIN - Age Ageing. 2023 Apr 1;52(4):. PMID: 37079868
MH  - Humans
MH  - Female
MH  - Aged
MH  - Male
MH  - Frail Elderly/psychology
MH  - Independent Living
MH  - *Frailty/diagnosis
MH  - Hand Strength
MH  - Exercise
MH  - Exercise Therapy
MH  - *Dementia/diagnosis/therapy
PMC - PMC9799251
OTO - NOTNLM
OT  - community-dwelling
OT  - exercise
OT  - functional ability
OT  - intrinsic capacity
OT  - older adults
OT  - older people
COIS- None.
EDAT- 2022/12/30 06:00
MHDA- 2023/01/03 06:00
PMCR- 2022/12/29
CRDT- 2022/12/29 14:04
PHST- 2022/07/30 00:00 [received]
PHST- 2022/12/29 14:04 [entrez]
PHST- 2022/12/30 06:00 [pubmed]
PHST- 2023/01/03 06:00 [medline]
PHST- 2022/12/29 00:00 [pmc-release]
AID - 6964933 [pii]
AID - afac303 [pii]
AID - 10.1093/ageing/afac303 [doi]
PST - ppublish
SO  - Age Ageing. 2022 Dec 5;51(12):afac303. doi: 10.1093/ageing/afac303.