PMID- 36580899
OWN - NLM
STAT- MEDLINE
DCOM- 20230605
LR  - 20230605
IS  - 1421-9867 (Electronic)
IS  - 0012-2823 (Linking)
VI  - 104
IP  - 3
DP  - 2023
TI  - Proton Pump Inhibitor Treatment Has Little Effects on Secretion of Saliva in 
      Patients with Proton Pump Inhibitor-Responsive Mild Reflux Esophagitis and 
      Non-Erosive Reflux Disease.
PG  - 187-192
LID - 10.1159/000528086 [doi]
AB  - INTRODUCTION: The secretion of saliva, which is triggered by acid reflux into the 
      esophagus via the esophagosalivary reflex, plays a crucial role in the defensive 
      mechanisms of the esophagus. The volume of saliva secreted in patients with 
      gastroesophageal reflux disease (GERD) is reduced. However, the effects of proton 
      pump inhibitors (PPI) on the secretion of saliva have rarely been reported. 
      Therefore, the present study investigated changes in the volume and pH of saliva 
      after the cessation of PPI. MATERIALS AND METHODS: We retrospectively reviewed 
      the records of consecutive patients previously diagnosed with mild reflux 
      esophagitis (RE) or non-erosive reflux disease (NERD) controlled with PPI 
      (including vonoprazan) who performed the salivary secretion test before and after 
      a 2-week cessation of PPI. The volume, pH, and pH after acid loading (buffering 
      capacity) of saliva were compared before and after the cessation of PPI. RESULTS: 
      Thirty-two patients (25 NERD, 7 mild RE) were included. The second saliva test 
      was performed a median interval of 14 months [12.0-15.3] after the first test. No 
      significant differences were observed in the volume of saliva secreted before and 
      after the cessation of PPI (before 4.0 mL [2.7-6.0] vs. after 4.0 mL [2.3-5.9], p 
      = 0.894). No significant differences were noted in pH or changes in pH after acid 
      loading before and after the cessation of PPI (pH: before 7.1 +/- 0.24 vs. after 
      7.0 +/- 0.24, p = 0.1. Delta pH after acid loading: before 1.0 [0.8-1.2] vs. after 
      1.0 [0.8-1.2], p = 0.844). CONCLUSION: The cessation of PPI did not appear to 
      affect the volume, pH, or buffering capacity of saliva in patients with 
      PPI-responsive mild RE and NERD.
CI  - (c) 2022 S. Karger AG, Basel.
FAU - Hoshikawa, Yoshimasa
AU  - Hoshikawa Y
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, Tokyo, Japan, y-hoshikawa@nms.ac.jp.
FAU - Momma, Eri
AU  - Momma E
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Hoshino, Shintaro
AU  - Hoshino S
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Kawami, Noriyuki
AU  - Kawami N
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Kitasako, Yuichi
AU  - Kitasako Y
AD  - Cariology and Operative Dentistry, Graduate School of Medical and Dental 
      Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
AD  - Dental Clinic, Ministry of Foreign Affairs, Tokyo, Japan.
FAU - Ikeda, Masaomi
AU  - Ikeda M
AD  - Oral Prosthetic Engineering, Graduate School, Tokyo Medical and Dental 
      University, Tokyo, Japan.
FAU - Iwakiri, Katsuhiko
AU  - Iwakiri K
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20221229
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Humans
MH  - *Esophagitis, Peptic/drug therapy/etiology
MH  - Proton Pump Inhibitors/pharmacology/therapeutic use
MH  - Saliva
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - *Gastroesophageal Reflux/drug therapy/diagnosis
OTO - NOTNLM
OT  - Gastroesophageal reflux
OT  - Proton pump inhibitors
OT  - Salivation
EDAT- 2022/12/30 06:00
MHDA- 2023/06/05 06:42
CRDT- 2022/12/29 18:22
PHST- 2022/09/03 00:00 [received]
PHST- 2022/11/12 00:00 [accepted]
PHST- 2023/06/05 06:42 [medline]
PHST- 2022/12/30 06:00 [pubmed]
PHST- 2022/12/29 18:22 [entrez]
AID - 000528086 [pii]
AID - 10.1159/000528086 [doi]
PST - ppublish
SO  - Digestion. 2023;104(3):187-192. doi: 10.1159/000528086. Epub 2022 Dec 29.