PMID- 36581227
OWN - NLM
STAT- MEDLINE
DCOM- 20230425
LR  - 20230425
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 130
IP  - 5
DP  - 2023 May
TI  - Incidence of Retinal Detachment, Macular Edema, and Ocular Hypertension after 
      Neodymium:Yttrium-Aluminum-Garnet Capsulotomy: A Population-Based Nationwide 
      Study-The French YAG 2 Study.
PG  - 478-487
LID - S0161-6420(22)01017-X [pii]
LID - 10.1016/j.ophtha.2022.12.022 [doi]
AB  - PURPOSE: To estimate the incidence and assess the risk factors associated with 3 
      adverse events (AEs) after neodymium:yttrium-aluminum-garnet posterior 
      capsulotomy (Nd:YAG-caps): ocular hypertension (OHT), macular edema (ME), and 
      retinal detachment (RD). DESIGN: Observational cohort study using a nationwide 
      claims database. PARTICIPANTS: Adults who underwent Nd:YAG-caps between 2014 and 
      2017, with no ocular disease history in the year before. METHODS: Patients who 
      underwent Nd:YAG-caps were identified using data from the French national 
      representative sample and followed up for 12 months postprocedure. The time to AE 
      was assessed using the Kaplan-Meier method. Factors associated with AE were 
      assessed using Cox models. MAIN OUTCOME MEASURES: Neodymium:YAG-caps 
      epidemiology, patients' characteristics, proportion of patients with AE, and 
      hazard ratios (HRs) associated with variables identified as factors associated 
      with AEs. RESULTS: During the study period, 6210 patients received Nd:YAG-caps 
      (7958 procedures). The mean age (+/- standard deviation) at Nd:YAG-caps was 75.0 (+/- 
      10.3) years. The 3-month and 12-month overall AE rates (>/= 1 AE of interest) were 
      8.6% and 13.3%, respectively. Among patients with >/= 1 AE of interest, 68.4% of 
      AEs occurred within 3 months post-Nd:YAG-caps. Three-month rates were  approximately 5% for OHT 
      and ME. Retinal detachment remained </= 0.5% over follow-up. Cox models showed that 
      patients with Nd:YAG-caps performed within 1 year after cataract surgery had a 
      higher risk of AEs than those with later Nd:YAG-caps (hazard ratio [HR], 1.314 
      [1.034-1.669], P = 0.0256), notably ME (HR, 1.500 [1.087-2.070], P = 0.0137). 
      Diabetic patients were more at risk of OHT (HR, 1.233 [1.005-1.513], P = 0.0448) 
      and ME (HR, 1.810 [1.446-2.266], P < 0.0001) than nondiabetic patients. Patients 
      with Nd:YAG-caps performed between 1 and 2 years after cataract surgery were more 
      at risk of OHT than patients with later Nd:YAG-caps (HR, 1.429 [1.185-1.723], P = 
      0.0002). CONCLUSIONS: According to a national claims database, OHT and ME were 
      the most frequent AEs of interest post-Nd:YAG-caps, mainly observed within 3 
      months postprocedure, highlighting the need for a close follow-up during this 
      period or a delayed capsulotomy. Diabetes and an early Nd:YAG-caps after cataract 
      surgery were among the main drivers for AE occurrence. FINANCIAL DISCLOSURE(S): 
      Proprietary or commercial disclosure may be found after the references.
CI  - Copyright (c) 2022 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Dot, Corinne
AU  - Dot C
AD  - Department of Ophthalmology, Desgenettes Military Hospital, Lyon, France. 
      Electronic address: corinnedot.pro@hotmail.fr.
FAU - Schweitzer, Cedric
AU  - Schweitzer C
AD  - CHU Bordeaux, Department of Ophthalmology, University of Bordeaux, ISPED, INSERM, 
      U1219-Bordeaux Population Health Research Centre, Bordeaux, France.
FAU - Labbe, Antoine
AU  - Labbe A
AD  - Department of Ophthalmology, Quinze-Vingts National Ophthalmology Hospital, 
      Paris, France.
FAU - Lignereux, Francois
AU  - Lignereux F
AD  - Department of Ophthalmology Sante Atlantique, Nantes Polyclinic, Nantes, France.
FAU - Rozot, Pascal
AU  - Rozot P
AD  - Department of Ophthalmology, Juge Clinic, Marseille, France.
FAU - Goguillot, Melanie
AU  - Goguillot M
AD  - Steve Consultants, Oullins, France.
FAU - Bugnard, Francoise
AU  - Bugnard F
AD  - Steve Consultants, Oullins, France.
FAU - Brezin, Antoine P
AU  - Brezin AP
AD  - Department of Ophthalmology, Cochin Hospital, APHP, Paris, France.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20221226
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
RN  - 2I87U3734A (Neodymium)
RN  - 0 (yttrium-aluminum-garnet)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - Aged, 80 and over
MH  - *Cataract Extraction/adverse effects
MH  - Neodymium
MH  - *Retinal Detachment/epidemiology/surgery/etiology
MH  - Incidence
MH  - *Macular Edema/epidemiology/etiology
MH  - *Lens Capsule, Crystalline/surgery
MH  - *Laser Therapy/adverse effects
MH  - *Capsule Opacification/epidemiology/etiology/surgery
MH  - *Ocular Hypertension/epidemiology/etiology
MH  - Postoperative Complications/etiology
OTO - NOTNLM
OT  - Adverse events
OT  - Cataract
OT  - Data claims
OT  - Database
OT  - Nd:YAG
OT  - Ophthalmology
OT  - Risk factors
EDAT- 2022/12/30 06:00
MHDA- 2023/04/25 06:42
CRDT- 2022/12/29 19:17
PHST- 2022/10/18 00:00 [received]
PHST- 2022/11/29 00:00 [revised]
PHST- 2022/12/20 00:00 [accepted]
PHST- 2023/04/25 06:42 [medline]
PHST- 2022/12/30 06:00 [pubmed]
PHST- 2022/12/29 19:17 [entrez]
AID - S0161-6420(22)01017-X [pii]
AID - 10.1016/j.ophtha.2022.12.022 [doi]
PST - ppublish
SO  - Ophthalmology. 2023 May;130(5):478-487. doi: 10.1016/j.ophtha.2022.12.022. Epub 
      2022 Dec 26.