PMID- 36581304
OWN - NLM
STAT- MEDLINE
DCOM- 20230315
LR  - 20230317
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Linking)
VI  - 109
DP  - 2023 Mar
TI  - Intravenous immunoglobulin (IVIG) promotes brain repair and improves cognitive 
      outcomes after traumatic brain injury in a FcgammaRIIB receptor-dependent manner.
PG  - 37-50
LID - S0889-1591(22)00476-7 [pii]
LID - 10.1016/j.bbi.2022.12.018 [doi]
AB  - Intravenous immunoglobulin (IVIG) is a promising immune-modulatory therapy for 
      limiting harmful inflammation and associated secondary tissue loss in 
      neurotrauma. Here, we show that IVIG therapy attenuates spatial learning and 
      memory deficits following a controlled cortical impact mouse model of traumatic 
      brain injury (TBI). These improvements in cognitive outcomes were associated with 
      increased neuronal survival, an overall reduction in brain tissue loss, and a 
      greater preservation of neural connectivity. Furthermore, we demonstrate that the 
      presence of the main inhibitory FcgammaRIIB receptor is required for the beneficial 
      effects of IVIG treatment in TBI, with our results simultaneously highlighting 
      the role of this receptor in reducing secondary damage arising from brain injury.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Willis, Emily F
AU  - Willis EF
AD  - School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, 
      Australia.
FAU - Gillespie, Ellen R
AU  - Gillespie ER
AD  - School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, 
      Australia.
FAU - Guse, Kirsten
AU  - Guse K
AD  - CSL Behring, Research, CSL Biologics Research Center, Bern, Switzerland.
FAU - Zuercher, Adrian W
AU  - Zuercher AW
AD  - CSL Behring, Research, CSL Biologics Research Center, Bern, Switzerland.
FAU - Kasermann, Fabian
AU  - Kasermann F
AD  - CSL Behring, Research, CSL Biologics Research Center, Bern, Switzerland.
FAU - Ruitenberg, Marc J
AU  - Ruitenberg MJ
AD  - School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, 
      Australia.
FAU - Vukovic, Jana
AU  - Vukovic J
AD  - School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, 
      Australia; Queensland Brain Institute, University of Queensland, Brisbane, 
      Queensland, Australia. Electronic address: j.vukovic@uq.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221226
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Immunoglobulins, Intravenous/pharmacology/therapeutic use
MH  - Brain
MH  - *Brain Injuries, Traumatic/complications
MH  - *Brain Injuries/complications
MH  - Cognition
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/12/30 06:00
MHDA- 2023/03/16 06:00
CRDT- 2022/12/29 19:18
PHST- 2022/08/19 00:00 [received]
PHST- 2022/12/13 00:00 [revised]
PHST- 2022/12/23 00:00 [accepted]
PHST- 2022/12/30 06:00 [pubmed]
PHST- 2023/03/16 06:00 [medline]
PHST- 2022/12/29 19:18 [entrez]
AID - S0889-1591(22)00476-7 [pii]
AID - 10.1016/j.bbi.2022.12.018 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2023 Mar;109:37-50. doi: 10.1016/j.bbi.2022.12.018. Epub 2022 
      Dec 26.