PMID- 36581953
OWN - NLM
STAT- MEDLINE
DCOM- 20230102
LR  - 20230206
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 21
IP  - 1
DP  - 2022 Dec 29
TI  - Prenatal exposure to heavy metal mixtures and anthropometric birth outcomes: a 
      cross-sectional study.
PG  - 139
LID - 10.1186/s12940-022-00950-z [doi]
LID - 139
AB  - BACKGROUND: Numerous studies have suggested significant associations between 
      prenatal exposure to heavy metals and newborn anthropometric measures. However, 
      little is known about the effect of various heavy metal mixtures at relatively 
      low concentrations. Hence, this study aimed to investigate associations between 
      prenatal exposures to a wide range of individual heavy metals and heavy metal 
      mixtures with anthropometric measures of newborns. METHODS: We recruited 975 
      mother-term infant pairs from two major hospitals in Israel. Associations between 
      eight heavy metals (arsenic, cadmium, chromium, mercury, nickel, lead, selenium, 
      and thallium) detected in maternal urine samples on the day of delivery with 
      weight, length, and head circumference at birth were estimated using linear and 
      Bayesian kernel machine regression (BKMR) models. RESULTS: Most heavy metals 
      examined in our study were observed in lower concentrations than in other 
      studies, except for selenium. In the linear as well as the BKMR models, birth 
      weight and length were negatively associated with levels of chromium. Birth 
      weight was found to be negatively associated with thallium and positively 
      associated with nickel. CONCLUSION: By using a large sample size and advanced 
      statistical models, we could examine the association between prenatal exposure to 
      metals in relatively low concentrations and anthropometric measures of newborns. 
      Chromium was suggested to be the most influential metal in the mixture, and its 
      associations with birth weight and length were found negative. Head circumference 
      was neither associated with any of the metals, yet the levels of metals detected 
      in our sample were relatively low. The suggested associations should be further 
      investigated and could shed light on complex biochemical processes involved in 
      intrauterine fetal development.
CI  - (c) 2022. The Author(s).
FAU - Michael, Tal
AU  - Michael T
AD  - Department of Epidemiology, Biostatistics, and Community Health Sciences, School 
      of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev 
      Beer-Sheva, Beersheba, Israel.
FAU - Kohn, Elkana
AU  - Kohn E
AD  - Clinical Pharmacology and Toxicology Unit, Pediatric Division, Shamir (Assaf 
      Harofeh) Medical Center, and Sackler School of Medicine, Tel-Aviv University, 
      Tel-Aviv, Israel.
FAU - Daniel, Sharon
AU  - Daniel S
AD  - Department of Epidemiology, Biostatistics, and Community Health Sciences, School 
      of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev 
      Beer-Sheva, Beersheba, Israel.
AD  - Clalit Health Services, Southern District, Beer-Sheva, Israel.
FAU - Hazan, Ariela
AU  - Hazan A
AD  - Clinical Pharmacology and Toxicology Unit, Pediatric Division, Shamir (Assaf 
      Harofeh) Medical Center, and Sackler School of Medicine, Tel-Aviv University, 
      Tel-Aviv, Israel.
FAU - Berkovitch, Matitiahu
AU  - Berkovitch M
AD  - Clinical Pharmacology and Toxicology Unit, Pediatric Division, Shamir (Assaf 
      Harofeh) Medical Center, and Sackler School of Medicine, Tel-Aviv University, 
      Tel-Aviv, Israel.
FAU - Brik, Anna
AU  - Brik A
AD  - Clinical Pharmacology and Toxicology Unit, Pediatric Division, Shamir (Assaf 
      Harofeh) Medical Center, and Sackler School of Medicine, Tel-Aviv University, 
      Tel-Aviv, Israel.
FAU - Hochwald, Ori
AU  - Hochwald O
AD  - Neonatal Intensive Care Unit, Rambam Health Care Campus, and Bruce Rappaport 
      Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
FAU - Borenstein-Levin, Liron
AU  - Borenstein-Levin L
AD  - Neonatal Intensive Care Unit, Rambam Health Care Campus, and Bruce Rappaport 
      Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
FAU - Betser, Moshe
AU  - Betser M
AD  - Delivery Rooms and Maternity Ward, Shamir (Assaf Harofeh) Medical Center, and 
      Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Moskovich, Miki
AU  - Moskovich M
AD  - Delivery Rooms and Maternity Ward, Shamir (Assaf Harofeh) Medical Center, and 
      Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Livne, Ayelet
AU  - Livne A
AD  - Neonatal Intensive Care Unit, Shamir (Assaf Harofeh) Medical Center, Sackler 
      School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Keidar, Rimona
AU  - Keidar R
AD  - Neonatal Intensive Care Unit, Shamir (Assaf Harofeh) Medical Center, Sackler 
      School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Rorman, Efrat
AU  - Rorman E
AD  - National Public Health Laboratory, Ministry of Health, Tel-Aviv, Israel.
FAU - Groisman, Luda
AU  - Groisman L
AD  - National Public Health Laboratory, Ministry of Health, Tel-Aviv, Israel.
FAU - Weiner, Zeev
AU  - Weiner Z
AD  - Department of Obstetrics and Gynecology, Rambam Health Care Campus and Bruce 
      Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, POB 
      9602, 31096, Haifa, Israel.
FAU - Rabin, Adi Malkoff
AU  - Rabin AM
AD  - Department of Obstetrics and Gynecology, Rambam Health Care Campus and Bruce 
      Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, POB 
      9602, 31096, Haifa, Israel.
FAU - Solt, Ido
AU  - Solt I
AD  - Department of Obstetrics and Gynecology, Rambam Health Care Campus and Bruce 
      Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, POB 
      9602, 31096, Haifa, Israel. i_solt@rambam.health.gov.il.
FAU - Levy, Amalia
AU  - Levy A
AD  - Department of Epidemiology, Biostatistics, and Community Health Sciences, School 
      of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev 
      Beer-Sheva, Beersheba, Israel.
AD  - Environment and Health Epidemiology Research Center, School of Public Health, 
      Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 
      Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221229
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - H6241UJ22B (Selenium)
RN  - 7OV03QG267 (Nickel)
RN  - AD84R52XLF (Thallium)
RN  - 0 (Metals, Heavy)
RN  - 0R0008Q3JB (Chromium)
SB  - IM
MH  - Pregnancy
MH  - Infant
MH  - Female
MH  - Infant, Newborn
MH  - Humans
MH  - *Selenium
MH  - Cross-Sectional Studies
MH  - Birth Weight
MH  - Nickel
MH  - *Prenatal Exposure Delayed Effects/epidemiology
MH  - Thallium
MH  - Bayes Theorem
MH  - *Metals, Heavy/adverse effects
MH  - Chromium
MH  - Maternal Exposure/adverse effects
PMC - PMC9798586
OTO - NOTNLM
OT  - Anthropometric Measures
OT  - BKMR
OT  - Metals
OT  - Pregnancy
OT  - Prenatal Exposure
COIS- The authors declare that they have no competing interests.
EDAT- 2022/12/30 06:00
MHDA- 2023/01/03 06:00
PMCR- 2022/12/29
CRDT- 2022/12/29 23:43
PHST- 2022/09/11 00:00 [received]
PHST- 2022/12/19 00:00 [accepted]
PHST- 2022/12/29 23:43 [entrez]
PHST- 2022/12/30 06:00 [pubmed]
PHST- 2023/01/03 06:00 [medline]
PHST- 2022/12/29 00:00 [pmc-release]
AID - 10.1186/s12940-022-00950-z [pii]
AID - 950 [pii]
AID - 10.1186/s12940-022-00950-z [doi]
PST - epublish
SO  - Environ Health. 2022 Dec 29;21(1):139. doi: 10.1186/s12940-022-00950-z.