PMID- 36582249 OWN - NLM STAT- MEDLINE DCOM- 20230102 LR - 20230117 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 13 DP - 2022 TI - Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus. PG - 1000982 LID - 10.3389/fimmu.2022.1000982 [doi] LID - 1000982 AB - B cells, follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells are part of a circuit that may play a role in the development or progression of rheumatoid arthritis (RA). With the aim of providing further insight into this topic, here we evaluated the frequency of different subsets of Tfh and Tfr in untreated and long-term treated RA patients from a cohort of Argentina, and their potential association with particular human leukocyte antigen (HLA) class-II variants and disease activity. We observed that the frequency of total Tfh cells as well as of particular Tfh subsets and Tfr cells were increased in seropositive untreated RA patients. Interestingly, when analyzing paired samples, the frequency of Tfh cells was reduced in synovial fluid compared to peripheral blood, while Tfr cells levels were similar in both biological fluids. After treatment, a decrease in the CCR7(lo)PD1(hi) Tfh subset and an increase in the frequency of Tfr cells was observed in blood. In comparison to healthy donors, seropositive patients with moderate and high disease activity exhibited higher frequency of Tfh cells while seropositive patients with low disease activity presented higher Tfr cell frequency. Finally, we observed that HLA-DRB1*09 presence correlated with higher frequency of Tfh and Tfr cells, while HLA-DRB1*04 was associated with increased Tfr cell frequency. Together, our results increase our knowledge about the dynamics of Tfh and Tfr cell subsets in RA, showing that this is altered after treatment. CI - Copyright (c) 2022 Ferrero, Onofrio, Acosta, Zacca, Ponce, Mussano, Onetti, Cadile, Costantino, Werner, Mas, Alvarellos, Montes, Acosta Rodriguez and Gruppi. FAU - Ferrero, Paola V AU - Ferrero PV AD - Laboratorio de Inmunologia, Hospital Nacional de Clinicas, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Onofrio, Luisina I AU - Onofrio LI AD - Centro de Investigaciones en Bioquimica Clinica e Inmunologia (CIBICI-CONICET), Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Acosta, Cristina Del Valle AU - Acosta CDV AD - Laboratorio de Inmunologia, Hospital Nacional de Clinicas, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Zacca, Estefania R AU - Zacca ER AD - Laboratorio de Inmunologia, Hospital Nacional de Clinicas, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Ponce, Nicolas E AU - Ponce NE AD - Centro de Investigaciones en Bioquimica Clinica e Inmunologia (CIBICI-CONICET), Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Mussano, Eduardo AU - Mussano E AD - Servicio de Reumatologia, Hospital Nacional de Clinicas, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Onetti, Laura B AU - Onetti LB AD - Servicio de Reumatologia, Hospital Nacional de Clinicas, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Cadile, Ignacio I AU - Cadile II AD - Servicio de Reumatologia, Hospital Nacional de Clinicas, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Costantino, Alicia B AU - Costantino AB AD - Laboratorio de Inmunologia, Hospital Nacional de Clinicas, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Werner, Marina L AU - Werner ML AD - Servicio de Reumatologia, Hospital Nacional de Clinicas, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Mas, Luciana A AU - Mas LA AD - Laboratorio de Histocompatibilidad, Hospital Privado Universitario de Cordoba e Instituto Universitario de Ciencias Biomedicas, Cordoba, Argentina. FAU - Alvarellos, Teresita AU - Alvarellos T AD - Laboratorio de Histocompatibilidad, Hospital Privado Universitario de Cordoba e Instituto Universitario de Ciencias Biomedicas, Cordoba, Argentina. FAU - Montes, Carolina L AU - Montes CL AD - Centro de Investigaciones en Bioquimica Clinica e Inmunologia (CIBICI-CONICET), Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Acosta Rodriguez, Eva V AU - Acosta Rodriguez EV AD - Centro de Investigaciones en Bioquimica Clinica e Inmunologia (CIBICI-CONICET), Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Gruppi, Adriana AU - Gruppi A AD - Centro de Investigaciones en Bioquimica Clinica e Inmunologia (CIBICI-CONICET), Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina. LA - eng GR - R01 AI110340/AI/NIAID NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20221213 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (HLA-DRB1 Chains) SB - IM MH - Humans MH - *T-Lymphocytes, Regulatory MH - T Follicular Helper Cells MH - HLA-DRB1 Chains/genetics MH - T-Lymphocytes, Helper-Inducer MH - *Arthritis, Rheumatoid PMC - PMC9793086 OTO - NOTNLM OT - DAS28-ESR OT - DMARDs OT - HLA-DRB1 OT - Tfh cells OT - Tfr cells OT - rheumatoid arthritis COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/12/31 06:00 MHDA- 2023/01/03 06:00 PMCR- 2022/01/01 CRDT- 2022/12/30 02:16 PHST- 2022/07/22 00:00 [received] PHST- 2022/11/28 00:00 [accepted] PHST- 2022/12/30 02:16 [entrez] PHST- 2022/12/31 06:00 [pubmed] PHST- 2023/01/03 06:00 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fimmu.2022.1000982 [doi] PST - epublish SO - Front Immunol. 2022 Dec 13;13:1000982. doi: 10.3389/fimmu.2022.1000982. eCollection 2022.