PMID- 36582253
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230103
IS  - 1178-7074 (Print)
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 15
DP  - 2022
TI  - Detecting Preeclampsia Severity Using Maternal-Obstetrical Characteristics and 
      Complete Blood Cell Counts.
PG  - 8715-8726
LID - 10.2147/IJGM.S392915 [doi]
AB  - PURPOSE: This study aimed to use the combination of maternal-obstetrical 
      characteristics (MOCs) and complete blood cell counts (CBCs) with different red 
      blood cell (RBC) indices as an alternative tool to detect preeclampsia (PE) 
      severity immediately before delivery. PATIENTS AND METHODS: This retrospective 
      study included all singleton pregnancies delivered after 24 weeks of gestation 
      from April 2016 to April 2020. Patients were divided into four different groups: 
      non-hypertensive (NH), gestational hypertension (GH), PE, and severe PE (SPE). 
      Univariate and forward stepwise multivariate logistic regression analysis was 
      conducted using MOCs, CBCs, and RBC indices. The calculation was performed 
      between SPE and other non-hypertensive and hypertensive (GH, PE) groups. 
      Moreover, the area under the curve (AUC) for the receiver operating 
      characteristic curve, sensitivity, and specificity were estimated. RESULTS: The 
      combined variables for differentiating SPE from NH were maternal age >29.5 years, 
      weight >27.24, gestational age <272 days at the time of blood withdrawal, 
      platelet count <217.5x103/muL, Srivastava indices <6.35, and Siradah indices 
      <43.02 (AUC, 0.834; 95% confidence interval [CI], 0.773-0.895). The combined 
      variables for differentiating SPE from GH were maternal age >29.5 years, body 
      mass index >25.28, gestational age <268.5 days at the time of blood withdrawal, 
      mean corpuscular volume <78.85 fL, and platelet count <234.5x103/muL (AUC, 0777; 
      95% CI, 0.703-0.852). The combined variables for differentiating SPE from PE were 
      maternal age >32.5 years, mean corpuscular hemoglobin concentration >34.55 g/dL, 
      and Siradah indices <40.05 (AUC, 0.745; 95% CI, 0.656-0.833). CONCLUSION: The 
      combination of selected variables from MOCs and CBCs with RBC indices before 
      delivery showed satisfactory results for detecting PE severity.
CI  - (c) 2022 Lu and Hsu.
FAU - Lu, Hsiao-Wen
AU  - Lu HW
AUID- ORCID: 0000-0003-1357-484X
AD  - Department of Obstetrics and Gynecology, Cardinal Tien Hospital, New Taipei City, 
      Taiwan.
AD  - Institute of Emergency and Critical Care Medicine, School of Medicine, National 
      Yang Ming Chiao Tung University, Taipei, Taiwan.
FAU - Hsu, Han-Shui
AU  - Hsu HS
AD  - Institute of Emergency and Critical Care Medicine, School of Medicine, National 
      Yang Ming Chiao Tung University, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20221223
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC9793784
OTO - NOTNLM
OT  - complete blood counts
OT  - hypertension
OT  - preeclampsia
OT  - preeclampsia severity
OT  - pregnancy
COIS- The authors report no conflicts of interest in this work.
EDAT- 2022/12/31 06:00
MHDA- 2022/12/31 06:01
PMCR- 2022/12/23
CRDT- 2022/12/30 02:16
PHST- 2022/10/17 00:00 [received]
PHST- 2022/12/18 00:00 [accepted]
PHST- 2022/12/30 02:16 [entrez]
PHST- 2022/12/31 06:00 [pubmed]
PHST- 2022/12/31 06:01 [medline]
PHST- 2022/12/23 00:00 [pmc-release]
AID - 392915 [pii]
AID - 10.2147/IJGM.S392915 [doi]
PST - epublish
SO  - Int J Gen Med. 2022 Dec 23;15:8715-8726. doi: 10.2147/IJGM.S392915. eCollection 
      2022.