PMID- 36582594
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230103
IS  - 2514-2119 (Electronic)
IS  - 2514-2119 (Linking)
VI  - 7
IP  - 1
DP  - 2023 Jan
TI  - Hypertrophic cardiomyopathy in identical twins: a case series.
PG  - ytac452
LID - 10.1093/ehjcr/ytac452 [doi]
LID - ytac452
AB  - BACKGROUND: Hypertrophic cardiomyopathy in identical twins is rare. Cases of 
      hypertrophic cardiomyopathy with homogenous and heterogeneous phenotypes have 
      been described in the literature. CASE SUMMARY: We report a pair of monozygotic 
      twins (Twin A and Twin B) with identical morphological expression of hypertrophic 
      cardiomyopathy. On initial evaluation, both twins had resting left ventricular 
      outflow tract obstruction, Grade II diastolic dysfunction, and New York Heart 
      Association (NYHA) Class II symptoms, but they had a different clinical course 
      afterward. Twin A progressed from NYHA Class II to Class III with a high left 
      ventricular outflow tract pressure gradient that was unresponsive to medical 
      treatment and required alcohol septal ablation. Twin B responded very well to 
      medical treatment. Both patients had no risk factors for sudden cardiac death, 
      and neither required an implantable cardioverter defibrillator. DISCUSSION: The 
      morphology of hypertrophic cardiomyopathy has a strong genetic basis, but 
      epigenetic factors may affect disease expression.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      European Society of Cardiology.
FAU - Ashraf, Muddasir
AU  - Ashraf M
AUID- ORCID: 0000-0001-9710-7610
AD  - Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's 
      Medical Centers, Advocate Aurora Health, 2801 W. Kinnickinnic River Parkway, Ste. 
      880, Milwaukee, WI 53215, USA.
FAU - Samad, Fatima
AU  - Samad F
AUID- ORCID: 0000-0002-7388-9205
AD  - Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's 
      Medical Centers, Advocate Aurora Health, 2801 W. Kinnickinnic River Parkway, Ste. 
      880, Milwaukee, WI 53215, USA.
FAU - Jahangir, Arshad
AU  - Jahangir A
AUID- ORCID: 0000-0001-5582-3336
AD  - Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's 
      Medical Centers, Advocate Aurora Health, 2801 W. Kinnickinnic River Parkway, Ste. 
      880, Milwaukee, WI 53215, USA.
FAU - Jan, Muhammad Fuad
AU  - Jan MF
AUID- ORCID: 0000-0001-5072-710X
AD  - Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's 
      Medical Centers, Advocate Aurora Health, 2801 W. Kinnickinnic River Parkway, Ste. 
      880, Milwaukee, WI 53215, USA.
FAU - Galazka, Patrycja
AU  - Galazka P
AUID- ORCID: 0000-0002-5952-7996
AD  - Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's 
      Medical Centers, Advocate Aurora Health, 2801 W. Kinnickinnic River Parkway, Ste. 
      880, Milwaukee, WI 53215, USA.
FAU - Tajik, Abdul Jamil
AU  - Tajik AJ
AUID- ORCID: 0000-0002-4784-1275
AD  - Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's 
      Medical Centers, Advocate Aurora Health, 2801 W. Kinnickinnic River Parkway, Ste. 
      880, Milwaukee, WI 53215, USA.
LA  - eng
PT  - Case Reports
DEP - 20221128
PL  - England
TA  - Eur Heart J Case Rep
JT  - European heart journal. Case reports
JID - 101730741
PMC - PMC9793770
OTO - NOTNLM
OT  - Case report
OT  - Environmental
OT  - Genetic
OT  - Hypertrophic cardiomyopathy
OT  - Identical twins
COIS- Conflict of interest: None declared.
EDAT- 2022/12/31 06:00
MHDA- 2022/12/31 06:01
PMCR- 2022/11/28
CRDT- 2022/12/30 02:26
PHST- 2022/05/26 00:00 [received]
PHST- 2022/07/04 00:00 [revised]
PHST- 2022/11/23 00:00 [accepted]
PHST- 2022/12/30 02:26 [entrez]
PHST- 2022/12/31 06:00 [pubmed]
PHST- 2022/12/31 06:01 [medline]
PHST- 2022/11/28 00:00 [pmc-release]
AID - ytac452 [pii]
AID - 10.1093/ehjcr/ytac452 [doi]
PST - epublish
SO  - Eur Heart J Case Rep. 2022 Nov 28;7(1):ytac452. doi: 10.1093/ehjcr/ytac452. 
      eCollection 2023 Jan.