PMID- 36584198
OWN - NLM
STAT- MEDLINE
DCOM- 20230103
LR  - 20230114
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 17
IP  - 12
DP  - 2022
TI  - Clinical features and outcomes of breakthrough vitreous hemorrhage secondary to 
      polypoidal choroidal vasculopathy.
PG  - e0279778
LID - 10.1371/journal.pone.0279778 [doi]
LID - e0279778
AB  - Polypoidal choroidal vasculopathy (PCV) with hemorrhagic complications is at 
      higher risk for breakthrough vitreous hemorrhage (VH). This study aimed to 
      evaluate the clinical features and outcomes of breakthrough VH secondary to PCV. 
      Data of patients receiving pars plana vitrectomy for breakthrough VH secondary to 
      PCV (VH group) were evaluated retrospectively and compared statistically to data 
      of age and sex-matched PCV patients without breakthrough VH (control group). 
      Among PCV patients, 36 eyes with breakthrough VH and 62 eyes without VH were 
      included. Compared with baseline, best corrected visual acuity (BCVA) was worse 
      in the VH group (P < 0.001), and improved postoperatively (P < 0.001). 
      Percentages of pigmented epithelial detachment (PED), hemorrhagic PED, massive 
      subretinal hemorrhage, hemorrhagic retinal detachment (RD), and hemorrhagic 
      choroidal detachment (CD) (P = 0.007) were higher in the VH group (P < 0.001). 
      Incidence of choroidal vascular hyperpermeability (P < 0.001), massive subretinal 
      hemorrhage (P = 0.001), hemorrhagic retinal detachment (P = 0.001) and 
      hemorrhagic type PCV (P = 0.001) was higher in patients with pachychoroid PCV, 
      while fibrovascular type had lower incidence (P < 0.001). Better initial BCVA (P 
      < 0.001), higher frequency of anti-VEGF treatment (P = 0.009), and previous 
      photodynamic therapy (P = 0.017) showed better visual outcomes. Breakthrough VH 
      risk is higher in PCV patients with massive subretinal hemorrhage, hemorrhagic 
      PED and hemorrhagic RD. BCVA and hemorrhagic complications improve significantly 
      postoperatively. Higher frequency of anti-VEGF treatment and previous 
      photodynamic therapy are associated with better visual prognosis in PCV patients 
      with breakthrough VH.
CI  - Copyright: (c) 2022 Li, Tsen. This is an open access article distributed under the 
      terms of the Creative Commons Attribution License, which permits unrestricted 
      use, distribution, and reproduction in any medium, provided the original author 
      and source are credited.
FAU - Li, Meng-Syuan
AU  - Li MS
AUID- ORCID: 0000-0002-6550-5064
AD  - Division of Ophthalmology, Pingtung Veterans General Hospital, Pingtung, Taiwan, 
      R.O.C.
AD  - Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, 
      Taiwan, R.O.C.
FAU - Tsen, Chui-Lien
AU  - Tsen CL
AUID- ORCID: 0000-0002-4997-3562
AD  - Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, 
      Taiwan, R.O.C.
AD  - Department of Optometry, Shu-Zen Junior College of Medicine and Management, 
      Kaohsiung, Taiwan, R.O.C.
LA  - eng
PT  - Journal Article
DEP - 20221230
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Angiogenesis Inhibitors)
SB  - IM
MH  - Humans
MH  - *Vitreous Hemorrhage/etiology/surgery
MH  - Polypoidal Choroidal Vasculopathy
MH  - Angiogenesis Inhibitors/therapeutic use
MH  - *Retinal Detachment/surgery/complications
MH  - Retrospective Studies
MH  - Retinal Hemorrhage/surgery/complications
MH  - Choroid/blood supply
MH  - Fluorescein Angiography
MH  - Tomography, Optical Coherence
PMC - PMC9803236
COIS- The authors declare no competing interests.
EDAT- 2022/12/31 06:00
MHDA- 2023/01/04 06:00
PMCR- 2022/12/30
CRDT- 2022/12/30 14:06
PHST- 2022/09/25 00:00 [received]
PHST- 2022/12/14 00:00 [accepted]
PHST- 2022/12/30 14:06 [entrez]
PHST- 2022/12/31 06:00 [pubmed]
PHST- 2023/01/04 06:00 [medline]
PHST- 2022/12/30 00:00 [pmc-release]
AID - PONE-D-22-26561 [pii]
AID - 10.1371/journal.pone.0279778 [doi]
PST - epublish
SO  - PLoS One. 2022 Dec 30;17(12):e0279778. doi: 10.1371/journal.pone.0279778. 
      eCollection 2022.