PMID- 36584587
OWN - NLM
STAT- MEDLINE
DCOM- 20230124
LR  - 20230201
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 643
DP  - 2023 Feb 5
TI  - Age-associated alterations of brain mitochondria energetics.
PG  - 1-7
LID - S0006-291X(22)01741-7 [pii]
LID - 10.1016/j.bbrc.2022.12.070 [doi]
AB  - The study aimed to explore the role of age-associated elevated cytosolic Ca(2+) 
      in changes of brain mitochondria energetic processes. Two groups of rats, young 
      adults (4 months) and advanced old (24 months), were evaluated for potential 
      alterations of mitochondrial parameters, the oxidative phosphorylation (OxPhos), 
      membrane potential, calcium retention capacity, activity of glutamate/aspartate 
      carrier (aralar), and ROS formation. We demonstrated that the brain mitochondria 
      of older animals have a lower resistance to Ca(2+) stress with resulting 
      consequences. The suppressed complex I OxPhos and decreased membrane potential 
      were accompanied by reduction of the Ca(2+) threshold required for induction of 
      mPTP. The Ca(2+) binding sites of mitochondrial aralar mediated a lower activity 
      of old brain mitochondria. The altered interaction between aralar and mPTP may 
      underlie mitochondrial dysregulation leading to energetic depression during 
      aging. At the advanced stages of aging, the declined metabolism is accompanied by 
      the diminished oxidative background.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Gainutdinov, Timur
AU  - Gainutdinov T
AD  - Department of Neurology, Otto von Guericke University, D-39120, Magdeburg, 
      Germany; Institute of Advanced Studies, Tatarstan Academy of Sciences, Kazan, 
      422111, Russian Federation.
FAU - Gizatullina, Zemfira
AU  - Gizatullina Z
AD  - Department of Neurology, Otto von Guericke University, D-39120, Magdeburg, 
      Germany.
FAU - Debska-Vielhaber, Grazyna
AU  - Debska-Vielhaber G
AD  - Department of Neurology, Otto von Guericke University, D-39120, Magdeburg, 
      Germany.
FAU - Vielhaber, Stefan
AU  - Vielhaber S
AD  - Department of Neurology, Otto von Guericke University, D-39120, Magdeburg, 
      Germany.
FAU - Feldmann, Robert E
AU  - Feldmann RE
AD  - Pain Center Clinic of Anaesthesiology and Intensive Care Medicine Medical Faculty 
      Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, 
      Germany.
FAU - Orynbayeva, Zulfiya
AU  - Orynbayeva Z
AD  - Department of Surgery, Drexel University College of Medicine, Philadelphia, PA, 
      19102, USA. Electronic address: zulfiya.orynbayeva@crl.com.
FAU - Gellerich, Frank Norbert
AU  - Gellerich FN
AD  - Department of Neurology, Otto von Guericke University, D-39120, Magdeburg, 
      Germany. Electronic address: labussee1968@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20221223
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Mitochondrial Membrane Transport Proteins)
RN  - SY7Q814VUP (Calcium)
SB  - IM
EIN - Biochem Biophys Res Commun. 2023 Jan 13;:. PMID: 36642657
MH  - Rats
MH  - Animals
MH  - *Mitochondrial Membrane Transport Proteins/metabolism
MH  - *Mitochondria/metabolism
MH  - Brain/metabolism
MH  - Oxidative Phosphorylation
MH  - Calcium/metabolism
OTO - NOTNLM
OT  - Aging
OT  - Aralar
OT  - Brain mitochondria
OT  - Ca(2+)
OT  - OxPhos
OT  - ROS
COIS- Declaration of competing interest The authors declare no conflict of interest.
EDAT- 2022/12/31 06:00
MHDA- 2023/01/25 06:00
CRDT- 2022/12/30 18:13
PHST- 2022/11/17 00:00 [received]
PHST- 2022/11/28 00:00 [revised]
PHST- 2022/12/22 00:00 [accepted]
PHST- 2022/12/31 06:00 [pubmed]
PHST- 2023/01/25 06:00 [medline]
PHST- 2022/12/30 18:13 [entrez]
AID - S0006-291X(22)01741-7 [pii]
AID - 10.1016/j.bbrc.2022.12.070 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2023 Feb 5;643:1-7. doi: 10.1016/j.bbrc.2022.12.070. 
      Epub 2022 Dec 23.