PMID- 36584956 OWN - NLM STAT- MEDLINE DCOM- 20230201 LR - 20230202 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 865 DP - 2023 Mar 20 TI - Historical biomonitoring of pollution trends in the North Pacific using archived samples from the Continuous Plankton Recorder Survey. PG - 161222 LID - S0048-9697(22)08326-7 [pii] LID - 10.1016/j.scitotenv.2022.161222 [doi] AB - First started in 1931, the Continuous Plankton Recorder (CPR) Survey is the longest-running and most geographically extensive marine plankton sampling program in the world. This pilot study investigates the feasibility of biomonitoring the spatiotemporal trends of marine pollution using archived CPR samples from the North Pacific. We selected specimens collected from three different locations (British Columbia Shelf, Northern Gulf of Alaska, and Aleutian Shelf) in the North Pacific between 2002 and 2020. Comprehensive profiling of the plankton chemical exposome was conducted using liquid and gas chromatography coupled with tandem mass spectrometry (LC-MS/MS and GC-MS/MS). Our results show that phthalates, plasticizers, persistent organic pollutants (POPs), pesticides, pharmaceuticals, and personal care products were present in the plankton exposome, and that many of these pollutants have decreased in amount over the last two decades, which was most pronounced for tri-n-butyl phosphate. In addition, the plankton exposome differed significantly by regional human activities, with the most polluted samples coming from the nearshore area. Exposome-wide association analysis revealed that bioaccumulation of environmental pollutants was highly correlated with the biomass of different plankton taxa. Overall, this study demonstrates that exposomic analysis of archived samples from the CPR Survey is effective for long-term biomonitoring of the spatial and temporal trends of environmental pollutants in the marine environment. CI - Copyright (c) 2022. Published by Elsevier B.V. FAU - Li, Kefeng AU - Li K AD - The Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America; Department of Medicine, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America. Electronic address: kli@health.ucsd.edu. FAU - Naviaux, Jane C AU - Naviaux JC AD - The Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America; Department of Neurosciences, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America. FAU - Lingampelly, Sai Sachin AU - Lingampelly SS AD - The Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America; Department of Medicine, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America. FAU - Wang, Lin AU - Wang L AD - The Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America; Department of Medicine, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America. FAU - Monk, Jonathan M AU - Monk JM AD - The Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America; Department of Medicine, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America. FAU - Taylor, Claire M AU - Taylor CM AD - The Marine Biological Association, The Laboratory, Citadel Hill, Plymouth, Devon PL1 2PB, UK. FAU - Ostle, Clare AU - Ostle C AD - The Marine Biological Association, The Laboratory, Citadel Hill, Plymouth, Devon PL1 2PB, UK. FAU - Batten, Sonia AU - Batten S AD - North Pacific Marine Science Organization (PICES), Sidney, BC V8L 4B2, Canada. FAU - Naviaux, Robert K AU - Naviaux RK AD - The Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America; Department of Medicine, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America; Department of Pediatrics, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America; Department of Pathology, University of California, San Diego School of Medicine, 214 Dickinson St., Bldg CTF, Rm C107, San Diego, CA 92103-8467, United States of America. Electronic address: rnaviaux@health.ucsd.edu. LA - eng PT - Journal Article DEP - 20221228 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Environmental Pollutants) SB - IM MH - Humans MH - *Plankton MH - Biological Monitoring MH - Tandem Mass Spectrometry MH - Chromatography, Liquid MH - Pilot Projects MH - Gas Chromatography-Mass Spectrometry MH - Environmental Monitoring MH - *Environmental Pollutants OTO - NOTNLM OT - Biomonitoring OT - Exposomics OT - Long-term surveillance OT - Marine pollution OT - Plankton COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/12/31 06:00 MHDA- 2023/02/02 06:00 CRDT- 2022/12/30 19:16 PHST- 2022/09/29 00:00 [received] PHST- 2022/12/13 00:00 [revised] PHST- 2022/12/23 00:00 [accepted] PHST- 2022/12/31 06:00 [pubmed] PHST- 2023/02/02 06:00 [medline] PHST- 2022/12/30 19:16 [entrez] AID - S0048-9697(22)08326-7 [pii] AID - 10.1016/j.scitotenv.2022.161222 [doi] PST - ppublish SO - Sci Total Environ. 2023 Mar 20;865:161222. doi: 10.1016/j.scitotenv.2022.161222. Epub 2022 Dec 28.