PMID- 36586102
OWN - NLM
STAT- MEDLINE
DCOM- 20230103
LR  - 20230124
IS  - 1488-2353 (Electronic)
IS  - 0147-958X (Linking)
VI  - 45
IP  - 4
DP  - 2022 Dec 31
TI  - Analysis Of The Association Between Sh2B1 chr16.28884655 And Type 2 Diabetes.
PG  - E33-38
LID - 10.25011/cim.v45i4.39273 [doi]
AB  - PURPOSE: To determine correlation between genetic susceptibility of type 2 
      diabetes mellitus (T2DM) and Src homology 2 B adapter protein 1 (SH2B1) gene 
      polymorphism in a diabetic population.  Methods: A total of 111 T2DM patients (DM 
      group) and 34 healthy controls (NC group) from Shanxi Provincial People's 
      Hospital were included in this study. Exon 9 of the SH2B1 gene was detected using 
      the Sanger sequencing method, and the relationship between SH2B1 gene 
      polymorphism and diabetes was analyzed.  Results: Comparison of the data between 
      the two groups showed that the values of TG, the updated HOMA of insulin 
      resistance (HOMA2-IR), weight, body mass index, waist circumference, fasting 
      blood glucose and fasting insulin levels of the DM group were higher than those 
      of the NC group (P < 0.05). The HOMA2 insulin sensitivity (%S) of the DM group 
      was lower than that of the NC group (P < 0.05). Sequencing analysis revealed that 
      the following five single nucleotide polymorphisms in exon 9 of SH2B1 may be 
      related to T2DM: rs181578610, rs550079240, chr16.28884655, chr16.28884659 and 
      chr16.28884831. Among them, chr16.28884655 was found to be significantly related 
      to diabetes; this site, located on the NM_015503 exon, was related to TG, LDL-C 
      and waist circumference. CONCLUSION: The SH2B1 gene locus chr16.28884655 was 
      found to be significantly related to genetic susceptibility to T2DM.
FAU - Liu, Jingjin
AU  - Liu J
AD  - Endocrinology, Shanxi Provincial People's Hospital, Taiyuan, China. 
      email@email.com.
FAU - Cao, Renjun
AU  - Cao R
AD  - Endocrinology, Heji Hospital affiliated to Changzhi Medical College, Changzhi, 
      China. email@email.com.
FAU - Li, Dewei
AU  - Li D
AD  - Endocrinology, Shanxi Provincial People's Hospital, Taiyuan, China. 
      email@email.com.
FAU - Miao, Fang
AU  - Miao F
AD  - Endocrinology, Shanxi Provincial People's Hospital, Taiyuan, China. 
      email@email.com.
FAU - Yang, Ping An
AU  - Yang PA
AD  - Endocrinology, Shanxi Provincial People's Hospital, Taiyuan, China. 
      email@email.com.
FAU - He, Hui
AU  - He H
AD  - Endocrinology, Shanxi Provincial People's Hospital, Taiyuan, China. 
      email@email.com.
FAU - Yu, Han
AU  - Yu H
AD  - Endocrinology, Shanxi Provincial People's Hospital, Taiyuan, China. 
      email@email.com.
FAU - Zhang, Xiang
AU  - Zhang X
AD  - Endocrinology, Shanxi Provincial People's Hospital, Taiyuan, China. 
      email@email.com.
FAU - Qin, Jie
AU  - Qin J
AD  - Endocrinology, Shanxi Provincial People's Hospital, Taiyuan, China. 
      email@email.com.
FAU - Yang, Yanlan
AU  - Yang Y
AD  - Endocrinology, Shanxi Provincial People's Hospital, Taiyuan, China. 
      xiangtianjiajiao@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221231
PL  - Canada
TA  - Clin Invest Med
JT  - Clinical and investigative medicine. Medecine clinique et experimentale
JID - 7804071
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (SH2B1 protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2
MH  - Genetic Predisposition to Disease
MH  - *Insulin Resistance/genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Body Mass Index
MH  - Blood Glucose/analysis/metabolism
MH  - Insulin
MH  - Adaptor Proteins, Signal Transducing/genetics/metabolism
OTO - NOTNLM
OT  - SH2B1
OT  - type 2 diabetes
OT  - single nucleotide polymorphism
OT  - genetic susceptibility
OT  - insulin resistance
EDAT- 2023/01/01 06:00
MHDA- 2023/01/04 06:00
CRDT- 2022/12/31 11:27
PHST- 2022/09/07 00:00 [received]
PHST- 2022/09/07 00:00 [accepted]
PHST- 2022/12/31 11:27 [entrez]
PHST- 2023/01/01 06:00 [pubmed]
PHST- 2023/01/04 06:00 [medline]
AID - 10.25011/cim.v45i4.39273 [doi]
PST - epublish
SO  - Clin Invest Med. 2022 Dec 31;45(4):E33-38. doi: 10.25011/cim.v45i4.39273.