PMID- 36586362
OWN - NLM
STAT- MEDLINE
DCOM- 20230321
LR  - 20230413
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 37
DP  - 2023
TI  - Neural correlates of impulsive compulsive behaviors in Parkinson's disease: A 
      Japanese retrospective study.
PG  - 103307
LID - S2213-1582(22)00372-2 [pii]
LID - 10.1016/j.nicl.2022.103307 [doi]
LID - 103307
AB  - BACKGROUND: Impulsive compulsive behaviors (ICBs) often disturb patients with 
      Parkinson's Disease (PD), of which impulse control disorder (ICD) and dopamine 
      dysregulation syndrome (DDS) are two major subsets. The nucleus accumbens (NAcc) 
      is involved in ICB; however, it remains unclear how the NAcc affects cortical 
      function and defines the different behavioral characteristics of ICD and DDS. 
      OBJECTIVES: To identify the cortico-striatal network primarily involved in ICB 
      and the differences in these networks between patients with ICD and DDS using 
      structural and resting-state functional magnetic resonance imaging. METHODS: 
      Patients with PD were recruited using data from a previous cohort study and 
      divided into those with ICB (ICB group) and without ICB (non-ICB group) using the 
      Japanese version of the Questionnaire for Impulsive Compulsive Disorders in 
      Parkinson's Disease (J-QUIP). From these two groups, we extracted 37 pairs 
      matched for age, sex, disease duration, and levodopa equivalent daily dose of 
      dopamine agonists. Patients with ICB were further classified as having ICD or DDS 
      based on the J-QUIP subscore. General linear models were used to compare gray 
      matter volume and functional connectivity (FC) of the NAcc, caudate, and putamen 
      between the ICB and non-ICB groups and between patients with ICD and those with 
      DDS. RESULTS: We found no significant differences in gray matter volumebetween 
      the ICB and non-ICB groups or between patients with ICD and those with DDS. 
      Compared with the non-ICB group, the FC of the right NAcc in the ICB group was 
      lower in the bilateral ventromedial prefrontal cortex and higher in the left 
      middle occipital gyrus. Furthermore, patients with DDS showed higher FC between 
      the right putamen and left superior temporal gyrus and higher FC between the left 
      caudate and bilateral middle occipital gyrus than patients with ICD. In contrast, 
      patients with ICD exhibited higher FC between the left NAcc and the right 
      posterior cingulate cortex than patients with DDS. CONCLUSIONS: The functionally 
      altered network between the right NAcc and ventromedial prefrontal cortex was 
      associated with ICB in PD. In addition, the surrounding cortico-striatal networks 
      may differentiate the behavioral characteristics of patients with ICD and those 
      with DDS.
CI  - Copyright (c) 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Kimura, Ikko
AU  - Kimura I
AD  - Department of Neurology, Osaka University Graduate School of Medicine, Suita 
      565-0871, Japan; Graduate School of Frontier Biosciences, Osaka University, Suita 
      565-0871, Japan.
FAU - Revankar, Gajanan S
AU  - Revankar GS
AD  - Department of Neurology, Osaka University Graduate School of Medicine, Suita 
      565-0871, Japan.
FAU - Ogawa, Kotaro
AU  - Ogawa K
AD  - Department of Neurology, Osaka University Graduate School of Medicine, Suita 
      565-0871, Japan.
FAU - Amano, Kaoru
AU  - Amano K
AD  - Graduate School of Frontier Biosciences, Osaka University, Suita 565-0871, Japan; 
      Graduate School of Information Science and Technology, The University of Tokyo, 
      Tokyo 113-8656, Japan.
FAU - Kajiyama, Yuta
AU  - Kajiyama Y
AD  - Department of Neurology, Osaka University Graduate School of Medicine, Suita 
      565-0871, Japan. Electronic address: kajiyama@neurol.med.osaka-u.ac.jp.
FAU - Mochizuki, Hideki
AU  - Mochizuki H
AD  - Department of Neurology, Osaka University Graduate School of Medicine, Suita 
      565-0871, Japan. Electronic address: hmochizuki@neurol.med.osaka-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221228
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Humans
MH  - *Parkinson Disease/complications/diagnostic imaging
MH  - Retrospective Studies
MH  - East Asian People
MH  - Impulsive Behavior/physiology
MH  - Dopamine
MH  - Compulsive Behavior/diagnostic imaging
PMC - PMC9817029
OTO - NOTNLM
OT  - Cortico-striatal network
OT  - Functional connectivity
OT  - Impulsive compulsive behaviors
OT  - Parkinson's disease
OT  - Voxel-based morphometry
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/01/01 06:00
MHDA- 2023/03/22 06:00
PMCR- 2022/12/28
CRDT- 2022/12/31 18:18
PHST- 2022/09/20 00:00 [received]
PHST- 2022/12/25 00:00 [revised]
PHST- 2022/12/26 00:00 [accepted]
PHST- 2023/01/01 06:00 [pubmed]
PHST- 2023/03/22 06:00 [medline]
PHST- 2022/12/31 18:18 [entrez]
PHST- 2022/12/28 00:00 [pmc-release]
AID - S2213-1582(22)00372-2 [pii]
AID - 103307 [pii]
AID - 10.1016/j.nicl.2022.103307 [doi]
PST - ppublish
SO  - Neuroimage Clin. 2023;37:103307. doi: 10.1016/j.nicl.2022.103307. Epub 2022 Dec 
      28.