PMID- 36586423
OWN - NLM
STAT- MEDLINE
DCOM- 20230331
LR  - 20230331
IS  - 2241-5955 (Electronic)
IS  - 1109-9666 (Linking)
VI  - 70
DP  - 2023 Mar-Apr
TI  - Peak exercise myocardial deformation indices during cardiopulmonary exercise 
      testing are associated with exercise capacity and ventilatory efficiency in 
      patients with dilated cardiomyopathy.
PG  - 28-35
LID - S1109-9666(22)00183-X [pii]
LID - 10.1016/j.hjc.2022.12.009 [doi]
AB  - OBJECTIVE: Little is known about the exercise-induced changes in the 
      multidimensional mechanical properties of the heart. We aimed to evaluate the 
      myocardial deformation indices (MDI) at rest and their response at peak exercise 
      during the same cardiopulmonary exercise testing (CPET) session, investigating 
      their relationship to exercise capacity and ventilatory sufficiency in dilated 
      cardiomyopathy (DCM) patients. METHODS: We evaluated left ventricular (LV) 
      function using speckle tracking imaging (STI) at rest and peak exercise during 
      the same CPET session in 57 idiopathic DCM patients in New York Heart Association 
      (NYHA) I-II class [54 +/- 12 years, 42 males, ejection fraction (EF) 33 +/- 9%]. We 
      measured global longitudinal strain (GLS), longitudinal strain rate at systole 
      (LSRS) and diastole (LSRD), and circumferential strain rate (CircS). RESULTS: 
      Resting GLS, LSRS, and LSRD were impaired compared with the predicted values but 
      were improved at peak exercise (p < 0.001). All MDI at rest and/or at peak 
      exercise were related to several CPET-derived parameters, including peak VO(2), 
      load, O(2) pulse, and VE/VCO(2) slope. Peak exercise LSRS > -1.10 sec(-1) (AUC = 
      0.80, p < 0.001) and GLS > -13% (AUC = 0.81, p = 0.002) predicted impaired 
      exercise capacity (peak VO(2) < 20 ml/min/kg) and ventilatory inefficiency 
      (VE/VCO(2) slope>34). In multiple regression analysis, peak exercise LSRS and GLS 
      were independently related to the peak VO(2) (Beta = -0.39, p = 0.003) and 
      VE/VCO(2) slope (Beta = 0.35, p = 0.02), respectively. CONCLUSIONS: Peak exercise 
      LSRS and GLS in NYHA I-II DCM patients subjected to CPET were associated with 
      aerobic exercise capacity and ventilatory efficiency. Consequently, LSRS and GLS 
      at peak exercise, through their association with CPET-derived CV risk indices, 
      may underline the severity of heart failure and predict future CV events in this 
      DCM population.
CI  - Copyright (c) 2022 Hellenic Society of Cardiology. Published by Elsevier B.V. All 
      rights reserved.
FAU - Triantafyllidi, Helen
AU  - Triantafyllidi H
AD  - 2(nd) Department of Cardiology, Medical School, National and Kapodistrian 
      University of Athens, ATTIKON Hospital, Athens, Greece. Electronic address: 
      seliani@hotmail.com.
FAU - Birmpa, Dionyssia
AU  - Birmpa D
AD  - 2(nd) Department of Cardiology, Medical School, National and Kapodistrian 
      University of Athens, ATTIKON Hospital, Athens, Greece.
FAU - Ikonomidis, Ignatios
AU  - Ikonomidis I
AD  - 2(nd) Department of Cardiology, Medical School, National and Kapodistrian 
      University of Athens, ATTIKON Hospital, Athens, Greece.
FAU - Benas, Dimitrios
AU  - Benas D
AD  - 2(nd) Department of Cardiology, Medical School, National and Kapodistrian 
      University of Athens, ATTIKON Hospital, Athens, Greece.
FAU - Makavos, George
AU  - Makavos G
AD  - 2(nd) Department of Cardiology, Medical School, National and Kapodistrian 
      University of Athens, ATTIKON Hospital, Athens, Greece.
FAU - Cokkinos, Dennis V
AU  - Cokkinos DV
AD  - Biomedical Research Foundation, Academy of Athens, Athens, Greece.
FAU - Triposkiadis, Filippos
AU  - Triposkiadis F
AD  - Department of Cardiology, Medical School, Larissa University, General Hospital, 
      Larissa, Greece.
FAU - Iliodromitis, Efstathios K
AU  - Iliodromitis EK
AD  - 2(nd) Department of Cardiology, Medical School, National and Kapodistrian 
      University of Athens, ATTIKON Hospital, Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20221228
PL  - Netherlands
TA  - Hellenic J Cardiol
JT  - Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese
JID - 101257381
SB  - IM
MH  - Male
MH  - Humans
MH  - Exercise Test/methods
MH  - *Cardiomyopathy, Dilated
MH  - Exercise Tolerance/physiology
MH  - Ventricular Function, Left/physiology
MH  - *Heart Failure
MH  - Exercise/physiology
MH  - Oxygen Consumption/physiology
MH  - Stroke Volume/physiology
OTO - NOTNLM
OT  - Dilated cardiomyopathy (DCM)
OT  - cardiopulmonary exercise test (CPET)
OT  - global longitudinal strain (GLS)
OT  - left ventricular myocardial deformation indices
OT  - left ventricular strain rate at systole (LSRS)
EDAT- 2023/01/01 06:00
MHDA- 2023/03/31 06:42
CRDT- 2022/12/31 19:12
PHST- 2022/09/18 00:00 [received]
PHST- 2022/12/16 00:00 [revised]
PHST- 2022/12/22 00:00 [accepted]
PHST- 2023/03/31 06:42 [medline]
PHST- 2023/01/01 06:00 [pubmed]
PHST- 2022/12/31 19:12 [entrez]
AID - S1109-9666(22)00183-X [pii]
AID - 10.1016/j.hjc.2022.12.009 [doi]
PST - ppublish
SO  - Hellenic J Cardiol. 2023 Mar-Apr;70:28-35. doi: 10.1016/j.hjc.2022.12.009. Epub 
      2022 Dec 28.