PMID- 36586517
OWN - NLM
STAT- MEDLINE
DCOM- 20230206
LR  - 20230206
IS  - 1618-0402 (Electronic)
IS  - 0940-9602 (Linking)
VI  - 246
DP  - 2023 Feb
TI  - Somatostatin: From a supporting actor to the protagonist to explain the long-term 
      effect of sleeve gastrectomy on glucose metabolism.
PG  - 152044
LID - S0940-9602(22)00159-5 [pii]
LID - 10.1016/j.aanat.2022.152044 [doi]
AB  - BACKGROUND: Bariatric/metabolic surgery has become the most effective treatment 
      against type 2 Diabetes mellitus (T2DM). The role of many gastrointestinal 
      hormones in T2DM has been proposed, but the pathophysiological models described 
      vary greatly depending on the anatomical rearrangements after surgery. We focus 
      on somatostatin as a common factor in two of the most commonly performed surgical 
      procedures in a healthy rodent model. We performed sleeve gastrectomy (SG) and 
      Roux-en-Y gastric bypass (RYGB) and also an experimental surgery without gastric 
      involvement (intestinal resection of 50 % jejunum-ileum portion -IR50 %). 
      METHODS: We used five groups of Wistar rats: fasting control, sham-operated, 
      SG-operated, RYGB-operated and IR50-operated. We analysed several parameters 4 
      and 23 weeks after surgery: plasma SST-14/28 fractions, plasma glucose, insulin 
      release and SST-producing cell expression in the duodenum and pancreatic islets. 
      RESULTS: Numerous SST-producing cells in the duodenum but a low number in the 
      pancreas and a long-term loss of glucose tolerance were observed in SG and RYGB 
      animals. Additionally, a high plasma SST-28 fraction was found in animals after 
      SG but not after RYGB. Finally, IR50 animals showed no differences versus 
      controls. CONCLUSIONS: In our SG model the amplitude of insulin response after 
      metabolic surgeries, is mediated by SST-28 plasma levels derived from the 
      proportional compensatory effect of gastric SST-producing tissue ablation. In 
      addition, a strong compensatory response to the surgical loss of gastric 
      SST-producing cells, leads to long-term loss of insulin production after SG but 
      not in the others.
CI  - Copyright (c) 2022 The Author(s). Published by Elsevier GmbH.. All rights reserved.
FAU - Perez-Arana, Gonzalo-Martin
AU  - Perez-Arana GM
AD  - Department of Human Anatomy and Embryology, University of Cadiz, Spain; Institute 
      for Biomedical Science Research and Innovation (INIBICA), University of Cadiz, 
      Spain. Electronic address: gonzalo.perez@uca.es.
FAU - Diaz-Gomez, Alfredo
AU  - Diaz-Gomez A
AD  - San Carlos Hospital, Andalusian Health System, Spain.
FAU - Bancalero-de Los Reyes, Jose
AU  - Bancalero-de Los Reyes J
AD  - Complejo Hospitalario de Badajoz, Servicio Extremeno de Salud, Spain.
FAU - Camacho-Ramirez, Alonso
AU  - Camacho-Ramirez A
AD  - Surgery Unit, Puerta del Mar University Hospital, University of Cadiz, Spain; 
      Institute for Biomedical Science Research and Innovation (INIBICA), University of 
      Cadiz, Spain.
FAU - Ribelles-Garcia, Antonio
AU  - Ribelles-Garcia A
AD  - Department of Human Anatomy and Embryology, University of Cadiz, Spain.
FAU - Almorza-Gomar, David
AU  - Almorza-Gomar D
AD  - Institute for Biomedical Science Research and Innovation (INIBICA), University of 
      Cadiz, Spain; Operative Statistic and Research Department, University of Cadiz, 
      Spain.
FAU - Gracia-Romero, Manuel
AU  - Gracia-Romero M
AD  - Department of Human Anatomy and Embryology, University of Cadiz, Spain.
FAU - Mateo-Gavira, Isabel
AU  - Mateo-Gavira I
AD  - Endocrine and Nutrition Service, Puerta del Mar University Hospital, University 
      of Cadiz, Spain.
FAU - Prada-Oliveira, Jose-Arturo
AU  - Prada-Oliveira JA
AD  - Department of Human Anatomy and Embryology, University of Cadiz, Spain; Institute 
      for Biomedical Science Research and Innovation (INIBICA), University of Cadiz, 
      Spain. Electronic address: arturo.prada@uca.es.
LA  - eng
PT  - Journal Article
DEP - 20221228
PL  - Germany
TA  - Ann Anat
JT  - Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische 
      Gesellschaft
JID - 100963897
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 51110-01-1 (Somatostatin)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Diabetes Mellitus, Type 2/surgery
MH  - Blood Glucose/metabolism
MH  - Rats, Wistar
MH  - Insulin
MH  - Gastrectomy/methods
MH  - Somatostatin
OTO - NOTNLM
OT  - Bariatric surgeries
OT  - Pancreas
OT  - Sleeve gastrectomy
OT  - Somatostatin
OT  - Type 2 diabetes mellitus
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/01/01 06:00
MHDA- 2023/02/07 06:00
CRDT- 2022/12/31 19:14
PHST- 2022/10/07 00:00 [received]
PHST- 2022/12/09 00:00 [revised]
PHST- 2022/12/11 00:00 [accepted]
PHST- 2023/01/01 06:00 [pubmed]
PHST- 2023/02/07 06:00 [medline]
PHST- 2022/12/31 19:14 [entrez]
AID - S0940-9602(22)00159-5 [pii]
AID - 10.1016/j.aanat.2022.152044 [doi]
PST - ppublish
SO  - Ann Anat. 2023 Feb;246:152044. doi: 10.1016/j.aanat.2022.152044. Epub 2022 Dec 
      28.