PMID- 36587911
OWN - NLM
STAT- MEDLINE
DCOM- 20230116
LR  - 20230116
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 314
DP  - 2023 Feb
TI  - Prenatal exposure to persistent organic pollutants and changes in infant growth 
      and childhood growth trajectories.
PG  - 137695
LID - S0045-6535(22)04188-1 [pii]
LID - 10.1016/j.chemosphere.2022.137695 [doi]
AB  - BACKGROUND: Children are born with a burden of persistent organic pollutants 
      (POPs) which may have endocrine disrupting properties and have been postulated to 
      contribute to the rise in childhood obesity. The current evidence is equivocal, 
      which may partly because many studies investigate the effects at one time point 
      during childhood. We assessed associations between prenatal exposure to POPs and 
      growth during infancy and childhood. METHODS: We used data from two Belgian 
      cohorts with cord blood measurements of five organochlorines 
      [(dichlorodiphenyldichloroethylene (p,p'-DDE), hexachlorobenzene (HCB), 
      polychlorinated biphenyls (PCB-138, -150, -180)] (N = 1418) and two 
      perfluoroalkyl substances [perfluorooctanoic acid (PFOA) and 
      perfluorooctanesulfonic acid (PFOS)] (N = 346). We assessed infant growth, 
      defined as body mass index (BMI) z-score change between birth and 2 years, and 
      childhood growth, characterized as BMI trajectory from birth to 8 years. To 
      evaluate associations between POP exposures and infant growth, we applied a 
      multi-pollutant approach, using penalized elastic net regression with stability 
      selection, controlling for covariates. To evaluate associations with childhood 
      growth, we used single-pollutant linear mixed models with random effects for 
      child individual, parametrized using a natural cubic spline formulation. RESULTS: 
      PCB-153 was associated with increased and p,p'-DDE with decreased infant growth, 
      although these results were imprecise. No clear association between any of the 
      exposures and longer-term childhood growth trajectories was observed. We did not 
      find evidence of effect modification by child sex. CONCLUSION: Our results 
      suggest that prenatal exposure to PCB-153 and p,p'-DDE may affect infant growth 
      in the first two years, with no evidence of more persistent effects.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Cai, Anran
AU  - Cai A
AD  - Institute for Risk Assessment Sciences, Department of Population Health Sciences, 
      Utrecht University, Utrecht, the Netherlands; VITO Health, Flemish Institute for 
      Technological Research (VITO), Mol, Belgium. Electronic address: a.cai@uu.nl.
FAU - Portengen, Lutzen
AU  - Portengen L
AD  - Institute for Risk Assessment Sciences, Department of Population Health Sciences, 
      Utrecht University, Utrecht, the Netherlands.
FAU - Govarts, Eva
AU  - Govarts E
AD  - VITO Health, Flemish Institute for Technological Research (VITO), Mol, Belgium.
FAU - Martin, Laura Rodriguez
AU  - Martin LR
AD  - VITO Health, Flemish Institute for Technological Research (VITO), Mol, Belgium.
FAU - Schoeters, Greet
AU  - Schoeters G
AD  - Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
FAU - Legler, Juliette
AU  - Legler J
AD  - Institute for Risk Assessment Sciences, Department of Population Health Sciences, 
      Utrecht University, Utrecht, the Netherlands.
FAU - Vermeulen, Roel
AU  - Vermeulen R
AD  - Institute for Risk Assessment Sciences, Department of Population Health Sciences, 
      Utrecht University, Utrecht, the Netherlands; Julius Center for Health Sciences 
      and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
FAU - Lenters, Virissa
AU  - Lenters V
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center 
      Utrecht, Utrecht, the Netherlands.
FAU - Remy, Sylvie
AU  - Remy S
AD  - VITO Health, Flemish Institute for Technological Research (VITO), Mol, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20221229
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
RN  - 0 (Persistent Organic Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - Child
MH  - Infant
MH  - Persistent Organic Pollutants
MH  - Dichlorodiphenyl Dichloroethylene
MH  - *Prenatal Exposure Delayed Effects/chemically induced
MH  - *Pediatric Obesity
MH  - *Polychlorinated Biphenyls/toxicity
MH  - *Environmental Pollutants/analysis
OTO - NOTNLM
OT  - Childhood growth trajectory
OT  - Infant growth
OT  - Longitudinal study
OT  - Multi-pollutant
OT  - Organochlorines
OT  - Poly- and perfluoroalkyl substances
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/01/02 06:00
MHDA- 2023/01/17 06:00
CRDT- 2023/01/01 19:16
PHST- 2022/08/30 00:00 [received]
PHST- 2022/12/25 00:00 [revised]
PHST- 2022/12/28 00:00 [accepted]
PHST- 2023/01/02 06:00 [pubmed]
PHST- 2023/01/17 06:00 [medline]
PHST- 2023/01/01 19:16 [entrez]
AID - S0045-6535(22)04188-1 [pii]
AID - 10.1016/j.chemosphere.2022.137695 [doi]
PST - ppublish
SO  - Chemosphere. 2023 Feb;314:137695. doi: 10.1016/j.chemosphere.2022.137695. Epub 
      2022 Dec 29.