PMID- 36588438
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230111
IS  - 1738-3684 (Print)
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Linking)
VI  - 19
IP  - 12
DP  - 2022 Dec
TI  - Triple-Network Dysconnectivity in Patients With First-Episode Psychosis and 
      Individuals at Clinical High Risk for Psychosis.
PG  - 1037-1045
LID - 10.30773/pi.2022.0091 [doi]
AB  - OBJECTIVE: In the triple-network model, the salience network (SN) plays a crucial 
      role in switching between the default-mode network (DMN) and the central 
      executive network (CEN). Aberrant patterns of triple-network connectivity have 
      been reported in schizophrenia patients, while findings have been less consistent 
      for patients in the early stages of psychotic disorders. Thus, the present study 
      examined the connectivity among the SN, DMN, and CEN in first-episode psychosis 
      (FEP) patients and individuals at clinical high risk (CHR) for psychosis. 
      METHODS: Thirty-nine patients with FEP, 78 patients with CHR for psychosis, and 
      110 healthy controls (HCs) underwent resting-state functional magnetic resonance 
      imaging. We compared the SN, DMN, and CEN connectivity patterns of the three 
      groups. The role of the SN in networks with significant connectivity differences 
      was examined by mediation analysis. RESULTS: FEP patients showed lower SN-DMN and 
      SN-CEN (cluster-level F=5.83, false discovery rate [FDR] corrected-p=0.001) 
      connectivity than HCs. There was lower SN-DMN connectivity (cluster-level F=3.06, 
      FDR corrected-p=0.053) at a trend level in CHR subjects compared to HCs. Between 
      HCs and FEP patients, mediation analysis showed that SN-DMN connectivity was a 
      mediator between group and SN-CEN connectivity. Additionally, SN-CEN connectivity 
      functioned as a mediator between group and SN-DMN connectivity. CONCLUSION: 
      Aberrant connectivity between the SN and DMN/CEN suggests disrupted network 
      switching in FEP patients, although CHR subjects showed trend-level SN-DMN 
      dysconnectivity. Our findings suggest that dysfunctional triple-network dynamics 
      centered on the SN can appear in patients in the early stages of psychotic 
      disorders.
FAU - Kim, Ahra
AU  - Kim A
AD  - Department of Brain and Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
FAU - Ha, Minji
AU  - Ha M
AD  - Department of Brain and Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
FAU - Kim, Taekwan
AU  - Kim T
AD  - Department of Bio and Brain Engineering, Korea Advanced Institute of Science and 
      Technology, Daejeon, Republic of Korea.
FAU - Park, Sunghyun
AU  - Park S
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
FAU - Lho, Silvia Kyungjin
AU  - Lho SK
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Moon, Sun-Young
AU  - Moon SY
AD  - Department of Psychiatry, Hallym University Kangnam Sacred Heart Hospital, Seoul, 
      Republic of Korea.
FAU - Kim, Minah
AU  - Kim M
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kwon, Jun Soo
AU  - Kwon JS
AD  - Department of Brain and Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
AD  - Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.
LA  - eng
GR  - 2019R1C1C1002457/National Research Foundation of Korea/
GR  - 2020M3E5D9079910/National Research Foundation of Korea/
GR  - 21-BR-03-01/Korea Brain Research Institute/
GR  - Ministry of Science and ICT/
PT  - Journal Article
DEP - 20221222
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC9806514
OTO - NOTNLM
OT  - Clinical high risk
OT  - First-episode psychosis
OT  - Salience network
OT  - Schizophrenia
OT  - Triple-network connectivity
COIS- Conflicts of Interest Jun Soo Kwon, a contributing editor of the Psychiatry 
      Investigation, was not involved in the editorial evaluation or decision to 
      publish this article. All remaining authors have declared no conflicts of 
      interest.
EDAT- 2023/01/03 06:00
MHDA- 2023/01/03 06:01
PMCR- 2022/12/01
CRDT- 2023/01/02 02:23
PHST- 2022/03/29 00:00 [received]
PHST- 2022/10/06 00:00 [accepted]
PHST- 2023/01/02 02:23 [entrez]
PHST- 2023/01/03 06:00 [pubmed]
PHST- 2023/01/03 06:01 [medline]
PHST- 2022/12/01 00:00 [pmc-release]
AID - pi.2022.0091 [pii]
AID - pi-2022-0091 [pii]
AID - 10.30773/pi.2022.0091 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2022 Dec;19(12):1037-1045. doi: 10.30773/pi.2022.0091. Epub 
      2022 Dec 22.