PMID- 36589707
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230103
IS  - 2090-8016 (Print)
IS  - 2090-0597 (Electronic)
IS  - 2090-0597 (Linking)
VI  - 2022
DP  - 2022
TI  - The Primary Alteration of Ventricular Myocardium Conduction: The Significant 
      Determinant of Left Bundle Branch Block Pattern.
PG  - 3438603
LID - 10.1155/2022/3438603 [doi]
LID - 3438603
AB  - Intraventricular conduction disturbances (IVCD) are currently generally accepted 
      as ECG diagnostic categories. They are characterized by defined QRS complex 
      patterns that reflect the abnormalities in the intraventricular sequence of 
      activation that can be caused by pathology in the His-Purkinje conduction system 
      (HP) or ventricular myocardium. However, the current understanding of the IVCD's 
      underlying mechanism is mostly attributed to HP structural or functional 
      alterations. The involvement of the working ventricular myocardium is only 
      marginally mentioned or not considered. This opinion paper is focused on the 
      alterations of the ventricular working myocardium leading to the most frequent 
      IVCD pattern-the left bundle branch block pattern (LBBB). Recognizing the 
      underlying mechanisms of the LBBB patterns and the involvement of the ventricular 
      working myocardium is of utmost clinical importance, considering a patient's 
      prognosis and indication for cardiac resynchronization therapy.
CI  - Copyright (c) 2022 Ljuba Bacharova and Bayes de Luna.
FAU - Bacharova, Ljuba
AU  - Bacharova L
AUID- ORCID: 0000-0003-1742-8962
AD  - International Laser Center CVTI, Bratislava, Slovakia.
FAU - de Luna, Bayes
AU  - de Luna B
AUID- ORCID: 0000-0003-1676-207X
AD  - Cardiovascular Research Foundation, Cardiovascular ICCC-Program, Research 
      Institute Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221220
PL  - United States
TA  - Cardiol Res Pract
JT  - Cardiology research and practice
JID - 101516542
PMC - PMC9800102
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2023/01/03 06:00
MHDA- 2023/01/03 06:01
PMCR- 2022/12/20
CRDT- 2023/01/02 04:05
PHST- 2022/11/12 00:00 [received]
PHST- 2022/12/06 00:00 [revised]
PHST- 2022/12/08 00:00 [accepted]
PHST- 2023/01/02 04:05 [entrez]
PHST- 2023/01/03 06:00 [pubmed]
PHST- 2023/01/03 06:01 [medline]
PHST- 2022/12/20 00:00 [pmc-release]
AID - 10.1155/2022/3438603 [doi]
PST - epublish
SO  - Cardiol Res Pract. 2022 Dec 20;2022:3438603. doi: 10.1155/2022/3438603. 
      eCollection 2022.