PMID- 36591962
OWN - NLM
STAT- MEDLINE
DCOM- 20230918
LR  - 20230928
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 58
IP  - 4
DP  - 2023 Oct
TI  - Effect of Metabolic Dysfunction-Associated Fatty Liver Disease on Left 
      Ventricular Deformation and Atrioventricular Coupling in Patients With Metabolic 
      Syndrome Assessed by MRI.
PG  - 1098-1107
LID - 10.1002/jmri.28588 [doi]
AB  - BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD) was 
      recently recognized as an important risk factor for cardiovascular diseases. 
      PURPOSE: To examine the effect of MAFLD on cardiac function in metabolic syndrome 
      by MRI. STUDY TYPE: Retrospective. POPULATION: One hundred seventy-nine patients 
      with metabolic syndrome (MetS), 101 with MAFLD (MAFLD [+]) and 78 without (MAFLD 
      [-]). Eighty-one adults without any of the components of MetS or cardiac 
      abnormalities were included as control group. FIELD STRENGTH/SEQUENCE: 3.0 T; 
      balanced steady-state free precession sequence. ASSESSMENT: Left atrial (LA) 
      strain was assessed during three phases: reservoir strain (LA-RS), conduit strain 
      (LA-CS), and booster strain (LA-BS). Left ventricular (LV) global longitudinal 
      (LV-GLS) strain was also derived. The left atrioventricular coupling index (LACI) 
      was calculated as the ratio of LA end-diastolic volume (LA-EDV) and LV-EDV. 
      STATISTICAL TESTS: Student's t test or Mann-Whitney U test; One-way analysis of 
      variance. A P value <0.05 was considered statistically significant. RESULTS: 
      Among MetS patients, individuals with MAFLD had significantly lower magnitude 
      LV-GLS (-11.6% +/- 3.3% vs. -13.8% +/- 2.7%) than those without MAFLD. For LA 
      strains, LA-RS (36.9% +/- 13.7% vs. 42.9% +/- 13.5%) and LA-CS (20.0% +/- 10.6% vs. 
      24.1% +/- 9.2%) were also significantly reduced in MAFLD (+) compared to MAFLD (-). 
      The LACIs (17.2% [12.9-21.2] % vs. 15.8% [12.2-19.7] %) were significantly higher 
      in patients with MAFLD compared to those without MAFLD. After adjustment for 
      other clinical factors, MAFLD was found to be independently correlated with 
      LV-GLS (beta = -0.270) and LACI (beta = 0.260). DATA CONCLUSION: MAFLD had an 
      unfavorable effect on LV myocardial strain in MetS. Moreover, LA strain and 
      atrioventricular coupling were further impaired in patients with concomitant 
      MAFLD compared to those without MAFLD. Last, MAFLD was independently associated 
      with subclinical LV dysfunction and atrioventricular coupling after adjustment 
      for other clinical factors. EVIDENCE LEVEL: 3 TECHNICAL EFFICACY: 3.
CI  - (c) 2023 International Society for Magnetic Resonance in Medicine.
FAU - Huang, Shan
AU  - Huang S
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Shi, Ke
AU  - Shi K
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Li, Yuan
AU  - Li Y
AUID- ORCID: 0000-0003-3681-6186
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Wang, Jin
AU  - Wang J
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Jiang, Li
AU  - Jiang L
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Gao, Yue
AU  - Gao Y
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Yan, Wei-Feng
AU  - Yan WF
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Shen, Li-Ting
AU  - Shen LT
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Yang, Zhi-Gang
AU  - Yang ZG
AUID- ORCID: 0000-0001-9341-7697
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230102
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
CIN - J Magn Reson Imaging. 2023 Oct;58(4):1108-1109. PMID: 36621892
MH  - Adult
MH  - Humans
MH  - Retrospective Studies
MH  - *Metabolic Syndrome/complications/diagnostic imaging
MH  - Echocardiography/adverse effects
MH  - *Ventricular Dysfunction, Left
MH  - *Non-alcoholic Fatty Liver Disease
MH  - Magnetic Resonance Imaging/adverse effects
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - atrioventricular coupling
OT  - left atrial strain
OT  - left ventricular strain
OT  - metabolic dysfunction-associated fatty liver disease
OT  - metabolic syndrome
EDAT- 2023/01/03 06:00
MHDA- 2023/09/18 12:43
CRDT- 2023/01/02 07:42
PHST- 2022/12/22 00:00 [revised]
PHST- 2022/11/05 00:00 [received]
PHST- 2022/12/23 00:00 [accepted]
PHST- 2023/09/18 12:43 [medline]
PHST- 2023/01/03 06:00 [pubmed]
PHST- 2023/01/02 07:42 [entrez]
AID - 10.1002/jmri.28588 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2023 Oct;58(4):1098-1107. doi: 10.1002/jmri.28588. Epub 
      2023 Jan 2.