PMID- 36594560
OWN - NLM
STAT- MEDLINE
DCOM- 20230215
LR  - 20230215
IS  - 2047-4849 (Electronic)
IS  - 2047-4830 (Linking)
VI  - 11
IP  - 4
DP  - 2023 Feb 14
TI  - Synergistic effects of arginine-glycine-aspartic acid and phosphatidylserine on 
      the surface immunomodulation and osseointegration of titanium implants.
PG  - 1358-1372
LID - 10.1039/d2bm01589g [doi]
AB  - The control of macrophage polarization is important in bone tissue regeneration 
      such as osseointegration. In this study, a coating method was developed to 
      improve the osseointegration of titanium (Ti) implants by generating an 
      immunomodulatory effect. The surface of the Ti discs was coated with a 
      poly(lactide-co-glycolide)(PLGA) polymer, phosphatidylserine (PS), and 
      arginine-glycine-aspartic acid (RGD) peptide conjugated phospholipid. In in vitro 
      assay using mouse bone marrow-derived macrophages (BMDMs), the most significant 
      expression of the M2 marker genes (Arg-1, YM-1, FIZZ1) and CD206, an M2 surface 
      marker, was obtained with coatings containing 6 mol% RGD conjugates and 
      phospholipids consisting of 50 mol% PS. The M2-inducing effect of RGD and PS was 
      also verified in rat femurs where coated Ti rods were implanted. The RGD and PS 
      coating significantly enhanced the osseointegration of the Ti implants. Moreover, 
      a biomechanical push-out test showed that the RGD and PS coating increased the 
      interfacial binding force between the bone and implants. These results indicate 
      that PS and RGD can be applied to the solid surface of implantable biomedical 
      devices to improve immunomodulation and tissue regeneration.
FAU - Wu, Lele
AU  - Wu L
AUID- ORCID: 0000-0002-3596-0293
AD  - Department of Dental Biomaterials Science, Dental Research Institute, School of 
      Dentistry, Seoul National University, 101, Deahak-ro, Jongno-gu, Seoul 03080, 
      South Korea. yanghc@snu.ac.kr.
FAU - Seon, Gyeung Mi
AU  - Seon GM
AUID- ORCID: 0000-0002-0766-1106
AD  - Department of Dental Biomaterials Science, Dental Research Institute, School of 
      Dentistry, Seoul National University, 101, Deahak-ro, Jongno-gu, Seoul 03080, 
      South Korea. yanghc@snu.ac.kr.
FAU - Ju, Sungwon
AU  - Ju S
AD  - Department of Dental Biomaterials Science, Dental Research Institute, School of 
      Dentistry, Seoul National University, 101, Deahak-ro, Jongno-gu, Seoul 03080, 
      South Korea. yanghc@snu.ac.kr.
FAU - Choi, Sang Hoon
AU  - Choi SH
AUID- ORCID: 0000-0003-3553-3109
AD  - Department of Dental Biomaterials Science, Dental Research Institute, School of 
      Dentistry, Seoul National University, 101, Deahak-ro, Jongno-gu, Seoul 03080, 
      South Korea. yanghc@snu.ac.kr.
FAU - Jiang, En-Shi
AU  - Jiang ES
AUID- ORCID: 0000-0003-1955-5420
AD  - Department of Dental Biomaterials Science, Dental Research Institute, School of 
      Dentistry, Seoul National University, 101, Deahak-ro, Jongno-gu, Seoul 03080, 
      South Korea. yanghc@snu.ac.kr.
FAU - Kim, Yongjoon
AU  - Kim Y
AD  - Department of Dental Biomaterials Science, Dental Research Institute, School of 
      Dentistry, Seoul National University, 101, Deahak-ro, Jongno-gu, Seoul 03080, 
      South Korea. yanghc@snu.ac.kr.
FAU - Chung, Shin Hye
AU  - Chung SH
AD  - Department of Dental Biomaterials Science, Dental Research Institute, School of 
      Dentistry, Seoul National University, 101, Deahak-ro, Jongno-gu, Seoul 03080, 
      South Korea. yanghc@snu.ac.kr.
FAU - Ahn, Jin-Soo
AU  - Ahn JS
AD  - Department of Dental Biomaterials Science, Dental Research Institute, School of 
      Dentistry, Seoul National University, 101, Deahak-ro, Jongno-gu, Seoul 03080, 
      South Korea. yanghc@snu.ac.kr.
FAU - Yang, Hyeong-Cheol
AU  - Yang HC
AUID- ORCID: 0000-0001-9420-7894
AD  - Department of Dental Biomaterials Science, Dental Research Institute, School of 
      Dentistry, Seoul National University, 101, Deahak-ro, Jongno-gu, Seoul 03080, 
      South Korea. yanghc@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20230214
PL  - England
TA  - Biomater Sci
JT  - Biomaterials science
JID - 101593571
RN  - D1JT611TNE (Titanium)
RN  - 0 (Phosphatidylserines)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Oligopeptides)
SB  - IM
MH  - Rats
MH  - Mice
MH  - Animals
MH  - *Osseointegration
MH  - *Titanium/pharmacology
MH  - Phosphatidylserines/pharmacology
MH  - Aspartic Acid
MH  - Coated Materials, Biocompatible/pharmacology
MH  - Oligopeptides/pharmacology
MH  - Surface Properties
EDAT- 2023/01/04 06:00
MHDA- 2023/02/16 06:00
CRDT- 2023/01/03 06:53
PHST- 2023/01/04 06:00 [pubmed]
PHST- 2023/02/16 06:00 [medline]
PHST- 2023/01/03 06:53 [entrez]
AID - 10.1039/d2bm01589g [doi]
PST - epublish
SO  - Biomater Sci. 2023 Feb 14;11(4):1358-1372. doi: 10.1039/d2bm01589g.