PMID- 36595654
OWN - NLM
STAT- MEDLINE
DCOM- 20230307
LR  - 20230317
IS  - 2472-1727 (Electronic)
VI  - 115
IP  - 5
DP  - 2023 Mar 15
TI  - The relationship between maternal periconceptional micronutrient supplementation 
      and non-syndromic cleft lip/palate in offspring.
PG  - 545-554
LID - 10.1002/bdr2.2146 [doi]
AB  - BACKGROUND: This study aimed to explore the relationship between maternal 
      periconceptional supplementation with folic acid only (FAO) or with multiple 
      micronutrients containing folic acid (MMFA) and non-syndromic cleft lip/palate in 
      offspring. METHOD: The data came from a prenatal health care system and a birth 
      defects surveillance system in Beijing, China, from 2013 to 2018. Information on 
      maternal FAO/MMFA supplementation was collected by questionnaire in the first 
      trimester, and data on cleft lip/palate were collected at delivery or termination 
      of pregnancy. Inverse probability weighting (IPW) by the propensity score to 
      adjust for the confounders and Poisson regression model was used to estimate risk 
      ratios (RRs) and their 95% confidence intervals (CIs). RESULTS: A total of 63,969 
      participants were included in the study. Compared to the no-supplementation 
      group, the adjusted RR for the supplementation group was 0.51 (95% CI: 0.40, 
      0.64). And the adjusted RRs for FAO and MMFA compared to the no-supplementation 
      group were 0.56 (95% CI: 0.40, 0.76) and 0.48 (95% CI: 0.35, 0.65), respectively. 
      Compared to supplement FAO and MMFA with less than 8 days out of 10 days, the 
      adjusted RRs for FAO and MMFA with 8 or more days out of 10 days were 1.17 (95% 
      CI: 0.78, 1.75), and 2.05 (95% CI: 1.37, 3.31), respectively. CONCLUSION: 
      Maternal supplementation with micronutrients, either FAO or MMFA, during the 
      periconceptional period can reduce the risk for non-syndromic cleft lip/palate in 
      offspring. However, women should be more cautious with MMFA supplementation.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Liu, Chunyi
AU  - Liu C
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing, China.
FAU - Wang, Di
AU  - Wang D
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing, China.
FAU - Jin, Lei
AU  - Jin L
AD  - Tongzhou Maternal and Child Health Hospital of Beijing, Beijing, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing, China.
FAU - Meng, Wenying
AU  - Meng W
AD  - Tongzhou Maternal and Child Health Hospital of Beijing, Beijing, China.
FAU - Jin, Lei
AU  - Jin L
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing, China.
FAU - Shang, Xuejun
AU  - Shang X
AD  - Department of Andrology, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, China.
AD  - Nanjing School of Clinical Medicine, Southern Medical University, Nanjing, China.
LA  - eng
GR  - 2018YFC1004300/National Key R&D Program of China/
GR  - 2018YFC1004303/National Key R&D Program of China/
GR  - 2018YFC1004301/National Key R&D Program of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230103
PL  - United States
TA  - Birth Defects Res
JT  - Birth defects research
JID - 101701004
RN  - 935E97BOY8 (Folic Acid)
RN  - 0 (Micronutrients)
SB  - IM
MH  - Pregnancy
MH  - Humans
MH  - Female
MH  - *Cleft Lip/epidemiology
MH  - *Cleft Palate/epidemiology
MH  - Risk Factors
MH  - Folic Acid
MH  - *Mouth Abnormalities
MH  - Micronutrients
OTO - NOTNLM
OT  - cleft lip
OT  - cleft lip/palate
OT  - cleft palate
OT  - folic acid
OT  - micronutrients
OT  - periconceptional period
EDAT- 2023/01/04 06:00
MHDA- 2023/03/08 06:00
CRDT- 2023/01/03 14:53
PHST- 2022/12/12 00:00 [revised]
PHST- 2022/10/25 00:00 [received]
PHST- 2022/12/21 00:00 [accepted]
PHST- 2023/01/04 06:00 [pubmed]
PHST- 2023/03/08 06:00 [medline]
PHST- 2023/01/03 14:53 [entrez]
AID - 10.1002/bdr2.2146 [doi]
PST - ppublish
SO  - Birth Defects Res. 2023 Mar 15;115(5):545-554. doi: 10.1002/bdr2.2146. Epub 2023 
      Jan 3.