PMID- 36595992
OWN - NLM
STAT- MEDLINE
DCOM- 20230105
LR  - 20230120
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 101
IP  - 52
DP  - 2022 Dec 30
TI  - Differential effects of hyperhomocysteinemia on the lipid profiles and lipid 
      ratios between patients with and without coronary artery disease: A retrospective 
      observational study.
PG  - e32464
LID - 10.1097/MD.0000000000032464 [doi]
LID - e32464
AB  - This study aimed to investigate the differential effects of hyperhomocysteinemia 
      (HHcy) on lipid profiles and lipid ratios between patients with coronary artery 
      disease (CAD) and without CAD. The data of 872 CAD patients and 774 non-CAD 
      controls were extracted from the information system of hospitalized patients. 
      Serum homocysteine (Hcy), total cholesterol (TC), triglycerides (TGs), 
      high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol 
      (LDL-C), apolipoprotein (Apo) AI, and ApoB concentrations were detected. HHcy was 
      defined as a serum level of Hcy >/= 15 mumol/L. The CAD patients had lower levels of 
      HDL-C and ApoAI and higher levels of Hcy than the controls (P < .05). Serum TGs 
      and HDL-C were negatively correlated with Hcy in controls. Serum HDL-C and ApoAI 
      were negatively correlated with Hcy, and the ratios of TC/HDL-C, TG/HDL-C, 
      LDL/HDL-C, and ApoB/ApoAI were positively correlated with Hcy in the CAD patients 
      (P < .05). Although the trends for HHcy to decrease the lipid profiles were not 
      different between the CAD and controls (Pinteraction > 0.05), CAD with HHcy had 
      lower HDL-C and ApoAI levels than those of subjects with normal Hcy; controls 
      with HHcy had lower TC, LDL-C, and ApoB levels than those of subjects with normal 
      Hcy (P < .05). There were different HHcy trends affecting the ratios of TC/HDL-C 
      and LDL/HDL-C between the CAD patients and controls (Pinteraction for 
      TC/HDL-C = 0.025; Pinteraction for LDL/HDL-C = 0.033). CAD patients with HHcy had 
      a higher ratio of TC/HDL-C (P = .022) and LDL/HDL-C (P = .045) than those of 
      patients with normal Hcy, but in the controls, the subjects with HHcy exhibited a 
      trend toward a decreased ratio of TC/HDL-C (P = .481) and LDL/HDL-C (P = .303). 
      There were differential effects of HHcy on the lipid ratios between CAD and 
      non-CAD patients. HHcy was related to higher ratios of TC/HDL-C and LDL/HDL-C in 
      patients with CAD.
CI  - Copyright (c) 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Wu, Dong-Feng
AU  - Wu DF
AUID- ORCID: 0000-0002-6479-6189
AD  - Department of Geriatric Cardiology, Guangxi Academy of Medical Sciences and the 
      People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
FAU - Liao, Qin-Chen
AU  - Liao QC
FAU - Lu, Feng
AU  - Lu F
FAU - Wang, Zhou
AU  - Wang Z
FAU - Yu, Kun
AU  - Yu K
FAU - Deng, Jin-Long
AU  - Deng JL
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Apolipoproteins B)
RN  - 0 (Triglycerides)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Apolipoprotein A-I)
SB  - IM
MH  - Humans
MH  - *Coronary Artery Disease
MH  - Cholesterol, LDL
MH  - *Hyperhomocysteinemia
MH  - Retrospective Studies
MH  - Apolipoproteins B
MH  - Triglycerides
MH  - Cholesterol, HDL
MH  - Apolipoprotein A-I
PMC - PMC9803476
COIS- The authors declare that there are no conflicts of interest regarding the 
      publication of this paper.
EDAT- 2023/01/04 06:00
MHDA- 2023/01/06 06:00
PMCR- 2022/12/30
CRDT- 2023/01/03 16:17
PHST- 2023/01/03 16:17 [entrez]
PHST- 2023/01/04 06:00 [pubmed]
PHST- 2023/01/06 06:00 [medline]
PHST- 2022/12/30 00:00 [pmc-release]
AID - 00005792-202212300-00024 [pii]
AID - 10.1097/MD.0000000000032464 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2022 Dec 30;101(52):e32464. doi: 
      10.1097/MD.0000000000032464.