PMID- 36596967
OWN - NLM
STAT- MEDLINE
DCOM- 20230307
LR  - 20230307
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 60
IP  - 4
DP  - 2023 Apr
TI  - Non-genomic Effect of Estradiol on the Neurovascular Unit and Possible 
      Involvement in the Cerebral Vascular Accident.
PG  - 1964-1985
LID - 10.1007/s12035-022-03178-7 [doi]
AB  - Cerebrovascular diseases, such as ischemic cerebral vascular accident (CVA), are 
      responsible for causing high rates of morbidity, mortality, and disability in the 
      population. The neurovascular unit (NVU) during and after ischemic CVA plays 
      crucial roles in cell regulation and preservation, the immune and inflammatory 
      response, and cell and/or tissue survival and repair. Cellular responses to 
      17beta-estradiol (E2) can be triggered by two mechanisms: one called classical or 
      genomic, which is due to the activation of the "classical" nuclear estrogen 
      receptors alpha (ERalpha) and beta (ERbeta), and the non-genomic or rapid mechanism, which is 
      due to the activation of the G protein-coupled estrogen receptor 1 (GPER) that is 
      located in the plasma membrane and some in intracellular membranes, such as in 
      the Golgi apparatus and endoplasmic reticulum. Nuclear receptors can regulate 
      gene expression and cellular functions. On the contrary, activating the GPER by 
      E2 and/or its G-1 agonist triggers several rapid cell signaling pathways. 
      Therefore, E2 or its G-1 agonist, by mediating GPER activation and/or expression, 
      can influence several NVU cell types. Most studies argue that the activation of 
      the GPER may be used as a potential therapeutic target in various pathologies, 
      such as CVA. Thus, with this review, we aimed to summarize the existing 
      literature on the role of GPER mediated by E2 and/or its agonist G-1 in the 
      physiology and pathophysiology of NVU.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Goncalves, Francisca Jorge
AU  - Goncalves FJ
AUID- ORCID: 0000-0002-0835-1708
AD  - CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. 
      Infante D. Henrique S/N, 6200-506, Covilha, Portugal.
AD  - FC-UBI - Faculty of Sciences, University of Beira Interior, 6201-001, Covilha, 
      Portugal.
FAU - Abrantes-Soares, Fatima
AU  - Abrantes-Soares F
AUID- ORCID: 0000-0001-6319-7873
AD  - CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. 
      Infante D. Henrique S/N, 6200-506, Covilha, Portugal.
AD  - FC-UBI - Faculty of Sciences, University of Beira Interior, 6201-001, Covilha, 
      Portugal.
FAU - Pouso, Manuel R
AU  - Pouso MR
AUID- ORCID: 0000-0001-9816-6284
AD  - CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. 
      Infante D. Henrique S/N, 6200-506, Covilha, Portugal.
AD  - FC-UBI - Faculty of Sciences, University of Beira Interior, 6201-001, Covilha, 
      Portugal.
FAU - Lorigo, Margarida
AU  - Lorigo M
AUID- ORCID: 0000-0002-4752-6398
AD  - CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. 
      Infante D. Henrique S/N, 6200-506, Covilha, Portugal.
AD  - FCS-UBI - Faculty of Health Sciences, University of Beira Interior, 6200-506, 
      Covilha, Portugal.
FAU - Cairrao, Elisa
AU  - Cairrao E
AUID- ORCID: 0000-0002-4823-5701
AD  - CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. 
      Infante D. Henrique S/N, 6200-506, Covilha, Portugal. ecairrao@fcsaude.ubi.pt.
AD  - FCS-UBI - Faculty of Health Sciences, University of Beira Interior, 6200-506, 
      Covilha, Portugal. ecairrao@fcsaude.ubi.pt.
LA  - eng
GR  - UIDB/00709/2020+UIDP/00709/2020/Fundacao para a Ciencia e a Tecnologia/
GR  - 2020.06616.BD/Fundacao para a Ciencia e a Tecnologia/
PT  - Journal Article
PT  - Review
DEP - 20230104
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 4TI98Z838E (Estradiol)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
SB  - IM
MH  - Humans
MH  - *Estradiol/pharmacology
MH  - Receptors, G-Protein-Coupled/metabolism
MH  - Signal Transduction
MH  - Estrogen Receptor alpha/metabolism
MH  - Estrogen Receptor beta/metabolism
MH  - *Stroke
MH  - Accidents
OTO - NOTNLM
OT  - 17beta-estradiol
OT  - Brain attack
OT  - G-1
OT  - Rapid effects
OT  - Stroke
EDAT- 2023/01/04 06:00
MHDA- 2023/03/08 06:00
CRDT- 2023/01/03 23:24
PHST- 2022/09/02 00:00 [received]
PHST- 2022/12/16 00:00 [accepted]
PHST- 2023/01/04 06:00 [pubmed]
PHST- 2023/03/08 06:00 [medline]
PHST- 2023/01/03 23:24 [entrez]
AID - 10.1007/s12035-022-03178-7 [pii]
AID - 10.1007/s12035-022-03178-7 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2023 Apr;60(4):1964-1985. doi: 10.1007/s12035-022-03178-7. Epub 
      2023 Jan 4.