PMID- 36597078
OWN - NLM
STAT- MEDLINE
DCOM- 20230105
LR  - 20230203
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Jan 4
TI  - Extra-intestinal manifestations of Celiac disease in children: their prevalence 
      and association with human leukocyte antigens and pathological and laboratory 
      evaluations.
PG  - 8
LID - 10.1186/s12887-022-03826-w [doi]
LID - 8
AB  - BACKGROUND: Celiac disease (CD) is an autoimmune disease caused by gluten intake. 
      Traditionally CD was believed to be a disease of the gut, although a wide range 
      of extra-intestinal manifestations (EIM) was recognized. The exact prevalence of 
      EIM and the associated risk factors have not been well studied. AIM: We aimed to 
      assess the prevalence of EIM in children with CD and their association with human 
      leukocyte antigen (HLA) typing, and pathological and laboratory indices. METHOD: 
      We conducted a cross-sectional study on children and adolescents with a definite 
      diagnosis of CD. They were followed in the main Celiac Clinic of Southern Iran. 
      RESULTS: We included 204 children who were visited between 2012 and 2017. Nearly 
      85% of them were positive for HLA-DQ2 and 40.6% for HLA-DQ8. The most prevalent 
      intestinal complaints reported were abdominal pain (42.6%) and chronic 
      constipation (19.1%). Failure-to-thrive (32.7%), iron deficiency anemia (25%), 
      short stature (20.5%), and eczema (18.6%) were the most common EIMs. However, 
      failure-to-thrive and short stature were presented at significantly younger ages, 
      whereas those patients with concomitant type 1 diabetes mellitus (DM) were 
      significantly older. We also found significant relationships between autoimmune 
      thyroid disease and HLA-DQ5, and the presence of headaches with HLA-DQ7. The 
      prevalence of HLA types of DQ2, DQ8, DQ6, and DQ7 significantly varied among 
      different Marsh groups. Patients who were positive for HLA-DQ8, were 
      significantly older, taller, and weightier. No significant association was found 
      between HLA types and any of the gastrointestinal symptoms, anti-tTG and 
      compliance to gluten free diet. Moreover, there were no statistically significant 
      differences detected between the presence of each individual EIM, the level of 
      IgA anti-tTG, sex, and Marsh typing. CONCLUSION: This study highlights the 
      presence of EIM in CD and their associated factors. We show the potential role of 
      HLA typing in some EIMs, which may shed light for future studies.
CI  - (c) 2023. The Author(s).
FAU - Salarian, Leila
AU  - Salarian L
AD  - Department of Pediatric Endocrinology, Shiraz University of Medical Sciences, 
      Shiraz, Iran.
AD  - Shiraz Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, 
      Iran.
FAU - Khavaran, Mohammad
AU  - Khavaran M
AD  - Department of Pediatric Endocrinology, Shiraz University of Medical Sciences, 
      Shiraz, Iran. Khavaranmd@gmail.com.
AD  - Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 
      Khavaranmd@gmail.com.
FAU - Dehghani, Seyed Mohsen
AU  - Dehghani SM
AD  - Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Mashhadiagha, Amirali
AU  - Mashhadiagha A
AD  - Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 
      mashhadiagha.a@gmail.com.
AD  - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. 
      mashhadiagha.a@gmail.com.
FAU - Moosavi, Seyed Ali
AU  - Moosavi SA
AD  - Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
AD  - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Rezaeianzadeh, Shayan
AU  - Rezaeianzadeh S
AD  - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230104
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Humans
MH  - Child
MH  - *Celiac Disease/complications/diagnosis/epidemiology
MH  - Prevalence
MH  - Cross-Sectional Studies
MH  - HLA Antigens/genetics
MH  - Diet, Gluten-Free
PMC - PMC9811781
OTO - NOTNLM
OT  - Celiac disease
OT  - Extra-intestinal manifestation
OT  - Gluten-free diet
OT  - Human leukocyte antigen
COIS- None.
EDAT- 2023/01/04 06:00
MHDA- 2023/01/06 06:00
PMCR- 2023/01/04
CRDT- 2023/01/03 23:35
PHST- 2022/07/30 00:00 [received]
PHST- 2022/12/28 00:00 [accepted]
PHST- 2023/01/03 23:35 [entrez]
PHST- 2023/01/04 06:00 [pubmed]
PHST- 2023/01/06 06:00 [medline]
PHST- 2023/01/04 00:00 [pmc-release]
AID - 10.1186/s12887-022-03826-w [pii]
AID - 3826 [pii]
AID - 10.1186/s12887-022-03826-w [doi]
PST - epublish
SO  - BMC Pediatr. 2023 Jan 4;23(1):8. doi: 10.1186/s12887-022-03826-w.