PMID- 36597781
OWN - NLM
STAT- MEDLINE
DCOM- 20230222
LR  - 20230222
IS  - 1477-0962 (Electronic)
IS  - 0961-2033 (Linking)
VI  - 32
IP  - 2
DP  - 2023 Feb
TI  - The potential causal association of systemic lupus erythematosus with congestive 
      heart failure in the East Asian population: A two-sample mendelian randomization 
      study.
PG  - 295-298
LID - 10.1177/09612033221149878 [doi]
AB  - OBJECTIVE: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease 
      that increases the risk of cardiovascular disease, but the causal relationship 
      has remained unknown in the East Asian population. We aim to determine the causal 
      relationship between SLE and congestive heart failure (CHF) in the East Asian 
      population. METHODS: We conducted a two-sample Mendelian randomization MR study 
      to examine the potential causal association of SLE with CHF, using the East Asian 
      genome-wide association study datasets for SLE (4222 cases, 8431 controls) and 
      CHF (9413 cases, 203,040 controls). RESULTS: The MR analysis showed that genetic 
      susceptibility to SLE was associated with the increased risk of CHF (odds ratio 
      [OR] 1.032, 95% confidence interval [CI] 1.004-1.061, p = .023). After excluding 
      the human leukocyte antigen (HLA) regions, SLE was also associated with a higher 
      risk of CHF (OR 1.034, 95% CI 1.007-1.062, p = .015). The multiple MR sensitivity 
      analyses confirmed that this potential causal association was unlikely to be 
      biased by horizontal pleiotropy. CONCLUSIONS: The findings of this MR study 
      suggest that SLE potentially increases the risk of CHF in the East Asian 
      population. Genetic predisposition to SLE may play a significant role in 
      developing CHF in the East Asian population.
FAU - Song, Euijun
AU  - Song E
AD  - Lerner Research Institute, 2569Cleveland Clinic, Cleveland, OH, USA.
AD  - Yonsei University College of Medicine, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20230104
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
SB  - IM
MH  - Humans
MH  - East Asian People
MH  - Genome-Wide Association Study
MH  - Mendelian Randomization Analysis
MH  - *Lupus Erythematosus, Systemic/complications/epidemiology/genetics
MH  - Genetic Predisposition to Disease
MH  - *Heart Failure/etiology/genetics
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Mendelian randomization
OT  - Systemic lupus erythematosus
OT  - cardio-rheumatology
OT  - genetic epidemiology
OT  - heart failure
EDAT- 2023/01/05 06:00
MHDA- 2023/02/22 06:00
CRDT- 2023/01/04 04:12
PHST- 2023/01/05 06:00 [pubmed]
PHST- 2023/02/22 06:00 [medline]
PHST- 2023/01/04 04:12 [entrez]
AID - 10.1177/09612033221149878 [doi]
PST - ppublish
SO  - Lupus. 2023 Feb;32(2):295-298. doi: 10.1177/09612033221149878. Epub 2023 Jan 4.