PMID- 36601584
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230111
IS  - 2296-889X (Print)
IS  - 2296-889X (Electronic)
IS  - 2296-889X (Linking)
VI  - 9
DP  - 2022
TI  - Elevated VCAM-1, MCP-1 and ADMA serum levels related to pulmonary fibrosis of 
      interstitial lung disease associated with rheumatoid arthritis.
PG  - 1056121
LID - 10.3389/fmolb.2022.1056121 [doi]
LID - 1056121
AB  - Introduction: Early diagnosis of interstitial lung disease (ILD) associated with 
      rheumatoid arthritis (RA) constitutes a challenge for the clinicians. Pulmonary 
      vasculopathy is relevant in the development of interstitial lung disease. 
      Accordingly, we aimed to explore the role of vascular cell adhesion molecule-1 
      (VCAM-1), monocyte chemoattractant protein-1 (MCP-1) and asymmetric 
      dimethylarginine (ADMA), key molecules in the vasculopathy, as potential 
      biomarkers of pulmonary fibrosis in RA-ILD(+). Methods: We included 21 RA-ILD(+) 
      patients and two comparative groups: 25 RA-ILD(-) patients and 21 idiopathic 
      pulmonary fibrosis (IPF) patients. Serum levels of the molecules were determined 
      by ELISA, and mRNA expression was quantified by qPCR. Results: VCAM-1, MCP-1 and 
      ADMA serum levels were increased in RA-ILD(+) patients in relation to RA-ILD(-) 
      and IPF patients. Additionally, RA-ILD(+) patients exhibited increased CCL2 (gene 
      encoding MCP-1) and decreased PRMT1 (gene related to ADMA synthesis) mRNA 
      expression in relation to RA-ILD(-) patients. A lower expression of VCAM1, CCL2, 
      and PRMT1 was observed in RA-ILD(+) patients when compared with those with IPF. 
      Furthermore, MCP-1 serum levels and PRMT1 mRNA expression were positively 
      correlated with RA duration, and ADMA serum levels were positively associated 
      with C-reactive protein in RA-ILD(+) patients. Conclusion: Our study suggests 
      that VCAM-1, MCP-1 and ADMA could be considered as useful biomarkers to identify 
      ILD in RA patients, as well as to discriminate RA-ILD(+) from IPF, contributing 
      to the early diagnosis of RA-ILD(+).
CI  - Copyright (c) 2022 Pulito-Cueto, Remuzgo-Martinez, Genre, Atienza-Mateo, 
      Mora-Cuesta, Iturbe-Fernandez, Lera-Gomez, Sebastian Mora-Gil, Prieto-Pena, 
      Portilla, Blanco, Corrales, Ocejo-Vinyals, Gualillo, Ferraz-Amaro, Cifrian, 
      Lopez-Mejias and Gonzalez-Gay.
FAU - Pulito-Cueto, Veronica
AU  - Pulito-Cueto V
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
FAU - Remuzgo-Martinez, Sara
AU  - Remuzgo-Martinez S
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
FAU - Genre, Fernanda
AU  - Genre F
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
FAU - Atienza-Mateo, Belen
AU  - Atienza-Mateo B
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
AD  - Department of Rheumatology, Hospital Universitario Marques de Valdecilla, 
      Santander, Cantabria, Spain.
FAU - Mora-Cuesta, Victor M
AU  - Mora-Cuesta VM
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
AD  - Department of Pneumology, Hospital Universitario Marques de Valdecilla, 
      Santander, Cantabria, Spain.
FAU - Iturbe-Fernandez, David
AU  - Iturbe-Fernandez D
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
AD  - Department of Pneumology, Hospital Universitario Marques de Valdecilla, 
      Santander, Cantabria, Spain.
FAU - Lera-Gomez, Leticia
AU  - Lera-Gomez L
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
FAU - Sebastian Mora-Gil, Maria
AU  - Sebastian Mora-Gil M
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
FAU - Prieto-Pena, Diana
AU  - Prieto-Pena D
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
AD  - Department of Rheumatology, Hospital Universitario Marques de Valdecilla, 
      Santander, Cantabria, Spain.
FAU - Portilla, Virginia
AU  - Portilla V
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
AD  - Department of Rheumatology, Hospital Universitario Marques de Valdecilla, 
      Santander, Cantabria, Spain.
FAU - Blanco, Ricardo
AU  - Blanco R
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
AD  - Department of Rheumatology, Hospital Universitario Marques de Valdecilla, 
      Santander, Cantabria, Spain.
FAU - Corrales, Alfonso
AU  - Corrales A
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
AD  - Department of Rheumatology, Hospital Universitario Marques de Valdecilla, 
      Santander, Cantabria, Spain.
FAU - Ocejo-Vinyals, J Gonzalo
AU  - Ocejo-Vinyals JG
AD  - Department of Immunology, Hospital Universitario Marques de Valdecilla, 
      Santander, Cantabria, Spain.
FAU - Gualillo, Oreste
AU  - Gualillo O
AD  - SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigacion Sanitaria 
      de Santiago), NEIRID Lab. (Neuroendocrine Interactions in rheumatology and 
      inflammatory diseases), Research laboratory 9, Santiago University Clinical 
      Hospital, Santiago de Compostela, Spain.
FAU - Ferraz-Amaro, Ivan
AU  - Ferraz-Amaro I
AD  - Department of Rheumatology, Hospital Universitario de Canarias, Santa Cruz de 
      Tenerife, Spain.
FAU - Cifrian, Jose M
AU  - Cifrian JM
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
AD  - Department of Pneumology, Hospital Universitario Marques de Valdecilla, 
      Santander, Cantabria, Spain.
AD  - School of Medicine, Universidad de Cantabria, Santander, Cantabria, Spain.
FAU - Lopez-Mejias, Raquel
AU  - Lopez-Mejias R
AD  - Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases 
      and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, 
      Cantabria, Spain.
FAU - Gonzalez-Gay, Miguel A
AU  - Gonzalez-Gay MA
AD  - Department of medicine and psychiatry, Universidad de Cantabria; Rheumatology 
      division, Hospital Universitario Marques de Valdecilla; Research group on genetic 
      epidemiology and atherosclerosis in systemic diseases and in metabolic diseases 
      of the musculoskeletal system, IDIVAL, Santander, Cantabria, Spain.
AD  - Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, 
      Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South 
      Africa.
LA  - eng
PT  - Journal Article
DEP - 20221219
PL  - Switzerland
TA  - Front Mol Biosci
JT  - Frontiers in molecular biosciences
JID - 101653173
PMC - PMC9806218
OTO - NOTNLM
OT  - ADMA
OT  - MCP-1
OT  - VCAM-1
OT  - biomarkers
OT  - interstitial lung disease
OT  - pulmonary fibrosis
OT  - rheumatoid arthritis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/06 06:00
MHDA- 2023/01/06 06:01
PMCR- 2022/01/01
CRDT- 2023/01/05 02:36
PHST- 2022/09/28 00:00 [received]
PHST- 2022/12/01 00:00 [accepted]
PHST- 2023/01/05 02:36 [entrez]
PHST- 2023/01/06 06:00 [pubmed]
PHST- 2023/01/06 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 1056121 [pii]
AID - 10.3389/fmolb.2022.1056121 [doi]
PST - epublish
SO  - Front Mol Biosci. 2022 Dec 19;9:1056121. doi: 10.3389/fmolb.2022.1056121. 
      eCollection 2022.