PMID- 3660313
OWN - NLM
STAT- MEDLINE
DCOM- 19871118
LR  - 20190503
IS  - 0040-6376 (Print)
IS  - 1468-3296 (Electronic)
IS  - 0040-6376 (Linking)
VI  - 42
IP  - 8
DP  - 1987 Aug
TI  - Measurement of effective pulmonary blood flow by soluble gas uptake in patients 
      with chronic airflow obstruction.
PG  - 604-14
AB  - A study was designed to assess the accuracy and reproducibility of rebreathing 
      and single breath soluble gas uptake measurements of effective pulmonary blood 
      flow (Q) in patients with airways obstruction. Both rebreathing (RB) and single 
      breath (SB) estimates of Q were compared with direct Fick and thermodilution (TD) 
      measurements of cardiac output at rest and during exercise in eight patients with 
      chronic, poorly reversible airflow obstruction with mean FEV1 65% predicted and 
      mean FEV1/FVC 53%. The mean (SD) resting values obtained were QRB 3.47 (0.46), 
      QSB 4.75 (1.15), QFick 4.77 (0.97), and QTD 5.15 (0.98). QRB was significantly 
      lower than the other three estimates, which did not differ significantly from 
      each other. Exercise produced significant increases in all four estimates for the 
      group. The mean exercise values were QRB 6.23 (1.19), QSB 7.62 (1.97), QFick 8.97 
      (1.96), and QTD 9.09 (1.00), both QRB and QSB being significantly less than QFick 
      and QTD. Analysis of variance of the rest, exercise, and combined data showed 
      highly significant relationships with the TD and Fick measurements for both QRB 
      and QSB over the range of values studied. In addition, the reproducibility of QRB 
      and QSB was assessed in 15 other patients with chronic airflow obstruction (mean 
      FEV1 42% predicted, FEV1/FVC 43%) and in 10 normal subjects. The coefficients of 
      intrasubject variability for a single measurement for QRB were 8.7% in normal 
      subjects and 10.2% in patients and for QSB were 11.7% in normal subjects and 
      16.1% in patients. The group differences from morning to afternoon, between days, 
      and over a month were not significant in the normal subjects. In the patients QRB 
      was slightly higher in the afternoon than in the morning of the same day, but the 
      differences between days and over a month were not significant for either test. 
      Although both tests detected the increase in pulmonary blood flow during 
      exercise, the single breath test was more accurate at rest. Some underestimation 
      was present for rebreathing at rest and for both tests during exercise, but this 
      can be allowed for. In patients with mild airflow obstruction the reproducibility 
      of the soluble gas uptake methods was similar to that of invasive catheter 
      methods of cardiac output estimation. The single breath test in particular was, 
      however, less reproducible in patients with more severe airflow obstruction, and 
      the rebreathing method may be more useful for detecting increases in pulmonary 
      blood flow in these patients.
FAU - Pierce, R J
AU  - Pierce RJ
AD  - Department of Thoracic Medicine, Repatriation General Hospital, Heidelberg, 
      Australia.
FAU - McDonald, C F
AU  - McDonald CF
FAU - Thuys, C A
AU  - Thuys CA
FAU - Rochford, P D
AU  - Rochford PD
FAU - Barter, C E
AU  - Barter CE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Thorax
JT  - Thorax
JID - 0417353
SB  - IM
MH  - Adult
MH  - Exercise Test
MH  - Humans
MH  - Lung/*blood supply
MH  - Lung Diseases, Obstructive/*physiopathology
MH  - Methods
MH  - Middle Aged
MH  - Regional Blood Flow
MH  - Respiratory Function Tests
MH  - Thermodilution
PMC - PMC460861
EDAT- 1987/08/01 00:00
MHDA- 1987/08/01 00:01
PMCR- 1990/08/01
CRDT- 1987/08/01 00:00
PHST- 1987/08/01 00:00 [pubmed]
PHST- 1987/08/01 00:01 [medline]
PHST- 1987/08/01 00:00 [entrez]
PHST- 1990/08/01 00:00 [pmc-release]
AID - 10.1136/thx.42.8.604 [doi]
PST - ppublish
SO  - Thorax. 1987 Aug;42(8):604-14. doi: 10.1136/thx.42.8.604.