PMID- 3660401
OWN - NLM
STAT- MEDLINE
DCOM- 19871103
LR  - 20190727
IS  - 0040-8727 (Print)
IS  - 0040-8727 (Linking)
VI  - 152
IP  - 3
DP  - 1987 Jul
TI  - Characteristics of anti-TSH receptor antibodies in two patients who developed 
      spontaneous hypothyroidism after antithyroid drug therapy for hyperthyroid 
      Graves' disease.
PG  - 269-75
AB  - Spontaneous hypothyroidism was developed in two patients with Graves' 
      hyperthyroidism 1.8 or 1 years after antithyroid drug therapy. In these patients 
      anti-thyrotropin (TSH) receptor antibodies were detected. Thyrotropin receptor 
      antibody (TRAb) index measured with TSH radioreceptor assay was 61.0% in case 1 
      and 68.0% in case 2 (normal value: -10 to 10%), and human thyroid adenylate 
      cyclase stimulating activities (HTACS) were 154% in case 1 and 190% in case 2 
      (normal value: 70 to 130%). IgG from case 1 suppressed the stimulating activity 
      of bovine TSH (bTSH) on thyroid adenylate cyclase in low concentrations in vitro. 
      These results indicate that a blocking type of anti-TSH receptor antibodies as 
      well as concomitant chronic thyroiditis might be a causative factor in patients 
      who developed spontaneous hypothyroidism shortly after the cessation of 
      antithyroid drugs.
FAU - Kaise, K
AU  - Kaise K
AD  - Second Department of Internal Medicine, Tohoku University School of Medicine, 
      Sendai.
FAU - Kaise, N
AU  - Kaise N
FAU - Yoshida, K
AU  - Yoshida K
FAU - Itagaki, Y
AU  - Itagaki Y
FAU - Yamamoto, M
AU  - Yamamoto M
FAU - Sakurada, T
AU  - Sakurada T
FAU - Saito, S
AU  - Saito S
FAU - Yoshinaga, K
AU  - Yoshinaga K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, Thyrotropin)
RN  - 9002-71-5 (Thyrotropin)
RN  - EC 4.6.1.1 (Adenylyl Cyclases)
SB  - IM
MH  - Adenylyl Cyclases/metabolism
MH  - Autoantibodies/*immunology
MH  - Enzyme Activation/drug effects
MH  - Female
MH  - Graves Disease/*drug therapy/immunology
MH  - Humans
MH  - Hypothyroidism/*immunology
MH  - Immunoglobulin G/physiology
MH  - Male
MH  - Middle Aged
MH  - Receptors, Thyrotropin/*immunology
MH  - Thyroid Gland/enzymology
MH  - Thyrotropin/pharmacology
EDAT- 1987/07/01 00:00
MHDA- 1987/07/01 00:01
CRDT- 1987/07/01 00:00
PHST- 1987/07/01 00:00 [pubmed]
PHST- 1987/07/01 00:01 [medline]
PHST- 1987/07/01 00:00 [entrez]
AID - 10.1620/tjem.152.269 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 1987 Jul;152(3):269-75. doi: 10.1620/tjem.152.269.