PMID- 36605413
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230111
IS  - 2472-1751 (Electronic)
IS  - 2472-1751 (Linking)
VI  - 6
IP  - 3
DP  - 2022 Jul
TI  - Structural white matter characteristics for working memory and 
      switching/inhibition in children with reading difficulties: The role of the left 
      superior longitudinal fasciculus.
PG  - 897-915
LID - 10.1162/netn_a_00257 [doi]
AB  - Reading difficulties (RDs) are characterized by slow and inaccurate reading as 
      well as additional challenges in cognitive control (i.e., executive functions, 
      especially in working memory, inhibition, and visual attention). Despite evidence 
      demonstrating differences in these readers' language and visual processing 
      abilities, white matter differences associated with executive functions (EFs) 
      difficulties in children with RDs are scarce. Structural correlates for reading 
      and EFs in 8- to 12-year-old children with RDs versus typical readers (TRs) were 
      examined using diffusion tensor imaging (DTI) data. Results suggest that children 
      with RDs showed significantly lower reading and EF abilities versus TRs. Lower 
      fractional anisotropy (FA) in left temporo-parietal tracts was found in children 
      with RDs, who also showed positive correlations between reading and working 
      memory and switching/inhibition scores and FA in the left superior longitudinal 
      fasciculus (SLF). FA in the left SLF predicted working memory performance 
      mediated by reading ability in children with RDs but not TRs. Our findings 
      support alterations in white matter tracts related to working memory, 
      switching/inhibition, and overall EF challenges in children with RDs and the 
      linkage between working memory difficulties and FA alterations in the left SLF in 
      children with RDs via reading.
CI  - (c) 2022 Massachusetts Institute of Technology.
FAU - Farah, Rola
AU  - Farah R
AD  - Educational Neuroimaging Group, Faculty of Education in Science and Technology, 
      Faculty of Biomedical Engineering, Technion - Israel Institute of Technology, 
      Haifa, Israel.
FAU - Glukhovsky, Noam
AU  - Glukhovsky N
AD  - Educational Neuroimaging Group, Faculty of Education in Science and Technology, 
      Faculty of Biomedical Engineering, Technion - Israel Institute of Technology, 
      Haifa, Israel.
FAU - Rosch, Keri
AU  - Rosch K
AD  - Kennedy Krieger Institute, Baltimore, MD, USA.
AD  - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School 
      of Medicine, Baltimore, MD, USA.
FAU - Horowitz-Kraus, Tzipi
AU  - Horowitz-Kraus T
AUID- ORCID: 0000-0003-0340-4708
AD  - Educational Neuroimaging Group, Faculty of Education in Science and Technology, 
      Faculty of Biomedical Engineering, Technion - Israel Institute of Technology, 
      Haifa, Israel.
AD  - Kennedy Krieger Institute, Baltimore, MD, USA.
AD  - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School 
      of Medicine, Baltimore, MD, USA.
LA  - eng
PT  - Journal Article
DEP - 20220701
PL  - United States
TA  - Netw Neurosci
JT  - Network neuroscience (Cambridge, Mass.)
JID - 101719149
PMC - PMC9810373
OTO - NOTNLM
OT  - Children
OT  - Executive functions
OT  - Fractional anisotropy
OT  - Reading difficulties
OT  - White Matter
EDAT- 2023/01/07 06:00
MHDA- 2023/01/07 06:01
PMCR- 2022/07/01
CRDT- 2023/01/06 02:33
PHST- 2021/09/16 00:00 [received]
PHST- 2022/06/02 00:00 [accepted]
PHST- 2023/01/06 02:33 [entrez]
PHST- 2023/01/07 06:00 [pubmed]
PHST- 2023/01/07 06:01 [medline]
PHST- 2022/07/01 00:00 [pmc-release]
AID - netn_a_00257 [pii]
AID - 10.1162/netn_a_00257 [doi]
PST - epublish
SO  - Netw Neurosci. 2022 Jul 1;6(3):897-915. doi: 10.1162/netn_a_00257. eCollection 
      2022 Jul.