PMID- 36606036
OWN - NLM
STAT- MEDLINE
DCOM- 20230109
LR  - 20230703
IS  - 1928-9022 (Electronic)
IS  - 0830-9000 (Print)
IS  - 0830-9000 (Linking)
VI  - 87
IP  - 1
DP  - 2023 Jan
TI  - Virulence comparison of 4 porcine circovirus type 2 (PCV-2) genotypes: 2a, 2b, 
      2d, and 2e with a single infection and co-infection with PCV-2 and porcine 
      reproductive and respiratory syndrome virus (PRRSV).
PG  - 41-50
AB  - The objective of this study was to compare the virulence of 4 porcine circovirus 
      type 2 (PCV-2) genotypes (2a, 2b, 2d, and 2e) in pigs singly infected with 1 of 
      these 4 PCV-2 genotypes and pigs dually infected with a combination of 1 of the 4 
      PCV-2 genotypes and porcine reproductive and respiratory syndrome virus (PRRSV). 
      Virulence was determined based on levels of PCV-2 loads in the blood and lymph 
      nodes and the severity of lymphoid lesion. Within the singly infected groups, 
      PCV-2a, PCV-2b, and PCV-2d resulted in a similar virulence to each other and all 
      were more virulent than the PCV-2e groups. Within the dually infected groups, the 
      combination of PCV-2d and PRRSV was more virulent than the other 3 PCV-2 
      genotypes (2a, 2b, and 2e), each in combination with PRRSV. Both PCV-2a+PRRSV and 
      PCV-2b+PRRSV were more virulent than PCV-2e+PRRSV in dually infected pigs. This 
      increased virulence of PCV-2d compared to the other 3 PCV-2 genotypes (2a, 2b, 
      and 2e) may be attributed to an extra amino acid (lysine residue) found within 
      open reading frame 2 (ORF2) of PCV-2d. In contrast, extra amino acids in ORF2 may 
      decrease the virulence of PCV-2e when compared to the other 3 PCV-2 genotypes 
      (2a, 2b, and 2d). The results of this study demonstrated that PCV-2d was the most 
      virulent PCV-2 genotype in pigs co-infected with PRRSV. The results also suggest 
      that genetic differences in the ORF2 of PCV-2 may affect the virulence of PCV-2 
      genotypes.
CI  - Copyright and/or publishing rights held by the Canadian Veterinary Medical 
      Association.
FAU - Suh, Jeongmin
AU  - Suh J
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Oh, Taehwan
AU  - Oh T
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can J Vet Res
JT  - Canadian journal of veterinary research = Revue canadienne de recherche 
      veterinaire
JID - 8607793
SB  - IM
MH  - Swine
MH  - Animals
MH  - *Porcine respiratory and reproductive syndrome virus/genetics
MH  - *Circovirus/genetics
MH  - *Coinfection/veterinary
MH  - Virulence/genetics
MH  - *Circoviridae Infections/veterinary
MH  - *Swine Diseases
MH  - Genotype
MH  - *Porcine Reproductive and Respiratory Syndrome
PMC - PMC9808848
EDAT- 2023/01/07 06:00
MHDA- 2023/01/10 06:00
PMCR- 2023/07/01
CRDT- 2023/01/06 02:46
PHST- 2022/05/20 00:00 [received]
PHST- 2022/07/21 00:00 [accepted]
PHST- 2023/01/06 02:46 [entrez]
PHST- 2023/01/07 06:00 [pubmed]
PHST- 2023/01/10 06:00 [medline]
PHST- 2023/07/01 00:00 [pmc-release]
AID - cjvr_01_41 [pii]
PST - ppublish
SO  - Can J Vet Res. 2023 Jan;87(1):41-50.