PMID- 36606061
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230111
IS  - 2052-8817 (Electronic)
IS  - 2052-8817 (Linking)
VI  - 10
IP  - 1
DP  - 2023 Jan-Dec
TI  - Incidence of adverse events for procedural sedation and analgesia for 
      cardioversion using thiopental in elderly patients: a multicenter prospective 
      observational study.
PG  - e812
LID - 10.1002/ams2.812 [doi]
LID - e812
AB  - AIM: The incidence and characteristics of thiopental-related adverse events (AEs) 
      in elderly patients during procedural sedation and analgesia (PSA) have not been 
      well studied. We aimed to characterize thiopental-related AE in elderly patients 
      during PSA and compare the incidence of AE in elderly patients with non-elderly 
      adults. METHODS: This is a secondary analysis of the Japanese Procedural Sedation 
      and Analgesia Registry (JPSTAR). We included all adult patients who received 
      thiopental for PSA in the emergency departments and excluded patients who 
      received concomitant sedative(s) in addition to thiopental or patients with 
      missing body weight data. We compared the incidence of AE between the non-elderly 
      (18-64 years) and elderly groups (>/=65 years). RESULTS: The JPSTAR had data on 379 
      patients who received thiopental for PSA and included 311 patients for analysis. 
      Most (222/311, 71.3%) were elderly. Cardioversion was the most common reason for 
      PSA (96.1%). The AE incidence between groups overall was similar, however, 
      hypoxia was significantly more frequent in the elderly compared with the 
      non-elderly group (10.3% versus 2.2%; adjusted odds 5.63, 95% confidence interval 
      1.27-25.0). The initial and total doses of thiopental were significantly lower in 
      the elderly group than in the non-elderly group (1.95 mg/kg versus 2.21 mg/kg and 
      2.33 mg/kg versus 2.93 mg/kg, respectively). CONCLUSIONS: Although elderly 
      patients received lower doses of thiopental, hypoxic events were significantly 
      more frequent in this group compared with the non-elderly patients. However, the 
      AE incidence was similar.
CI  - (c) 2023 The Authors. Acute Medicine & Surgery published by John Wiley & Sons 
      Australia, Ltd on behalf of Japanese Association for Acute Medicine.
FAU - Hayashi, Minoru
AU  - Hayashi M
AUID- ORCID: 0000-0002-0160-6288
AD  - Department of Emergency Medicine Fukui Prefectural Hospital Fukui Japan.
FAU - Norii, Tatsuya
AU  - Norii T
AUID- ORCID: 0000-0001-7428-5625
AD  - Department of Emergency Medicine University of New Mexico Health Sciences Center 
      Albuquerque New Mexico USA.
FAU - Albright, Danielle
AU  - Albright D
AUID- ORCID: 0000-0002-0503-3050
AD  - Department of Emergency Medicine University of New Mexico Health Sciences Center 
      Albuquerque New Mexico USA.
FAU - Crandall, Cameron
AU  - Crandall C
AUID- ORCID: 0000-0002-4459-8409
AD  - Department of Emergency Medicine University of New Mexico Health Sciences Center 
      Albuquerque New Mexico USA.
LA  - eng
PT  - Journal Article
DEP - 20230102
PL  - United States
TA  - Acute Med Surg
JT  - Acute medicine & surgery
JID - 101635464
PMC - PMC9807845
OTO - NOTNLM
OT  - Adverse effects
OT  - analgesia and anesthesia
OT  - cardioversion
OT  - elderly
OT  - thiopental
EDAT- 2023/01/07 06:00
MHDA- 2023/01/07 06:01
PMCR- 2023/01/02
CRDT- 2023/01/06 02:46
PHST- 2022/10/11 00:00 [received]
PHST- 2022/12/11 00:00 [accepted]
PHST- 2023/01/06 02:46 [entrez]
PHST- 2023/01/07 06:00 [pubmed]
PHST- 2023/01/07 06:01 [medline]
PHST- 2023/01/02 00:00 [pmc-release]
AID - AMS2812 [pii]
AID - 10.1002/ams2.812 [doi]
PST - epublish
SO  - Acute Med Surg. 2023 Jan 2;10(1):e812. doi: 10.1002/ams2.812. eCollection 2023 
      Jan-Dec.