PMID- 36607143
OWN - NLM
STAT- MEDLINE
DCOM- 20230215
LR  - 20230215
IS  - 2047-4849 (Electronic)
IS  - 2047-4830 (Linking)
VI  - 11
IP  - 4
DP  - 2023 Feb 14
TI  - Cationic phosphorus dendron nanomicelles deliver microRNA mimics and microRNA 
      inhibitors for enhanced anti-inflammatory therapy of acute lung injury.
PG  - 1530-1539
LID - 10.1039/d2bm01807a [doi]
AB  - The development of efficient nanomedicines to repress the repolarization of M1 
      phenotype macrophages and therefore inhibit pro-inflammatory cytokine 
      overexpression for anti-inflammatory therapy is still a challenging task. We 
      report here an original gene delivery nanoplatform based on 
      pyrrolidinium-modified amphiphilic generation 1 phosphorus dendron (C12G1) 
      nanomicelles with a rigid phosphorous dendron structure. The nanomicelles display 
      higher gene delivery efficiency than the counterpart materials of 
      pyrrolidinium-modified G1 phosphorus dendrimers, and meanwhile exhibit excellent 
      cytocompatibility. The C12G1 nanomicelles can be employed to co-deliver the 
      miRNA-146a mimic (miR-146a mimic) and miRNA-429 inhibitor (miR-429i) to inhibit 
      the Toll-like receptor-4 signaling pathway and p38 mitogen-activated protein 
      kinase signaling pathway, respectively, thus causing repression of M1 phenotype 
      alveolar macrophage polarization. The developed C12G1/miR-mixture polyplexes 
      enable efficient therapy of lipopolysaccharide-activated alveolar macrophages in 
      vitro and an acute lung injury mouse model in vivo. The generated cationic 
      phosphorus dendron nanomicelles may hold promising potential for 
      anti-inflammatory gene therapy of other inflammatory diseases.
FAU - Li, Jin
AU  - Li J
AD  - State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, 
      Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative 
      Medicine, College of Biological Science and Medical Engineering, Donghua 
      University, Shanghai 201620, P. R. China. mwshen@dhu.edu.cn.
AD  - Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, BP 44099, 
      31077 Toulouse CEDEX 4, France.
FAU - Chen, Liang
AU  - Chen L
AUID- ORCID: 0000-0001-7429-4505
AD  - State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, 
      Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative 
      Medicine, College of Biological Science and Medical Engineering, Donghua 
      University, Shanghai 201620, P. R. China. mwshen@dhu.edu.cn.
AD  - Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, BP 44099, 
      31077 Toulouse CEDEX 4, France.
FAU - Sun, Huxiao
AU  - Sun H
AD  - State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, 
      Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative 
      Medicine, College of Biological Science and Medical Engineering, Donghua 
      University, Shanghai 201620, P. R. China. mwshen@dhu.edu.cn.
FAU - Zhan, Mengsi
AU  - Zhan M
AD  - State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, 
      Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative 
      Medicine, College of Biological Science and Medical Engineering, Donghua 
      University, Shanghai 201620, P. R. China. mwshen@dhu.edu.cn.
FAU - Laurent, Regis
AU  - Laurent R
AD  - Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, BP 44099, 
      31077 Toulouse CEDEX 4, France.
AD  - Universite de Toulouse, UPS, INPT, 31077 Toulouse CEDEX 4, France.
FAU - Mignani, Serge
AU  - Mignani S
AD  - Universite Paris Descartes, PRES Sorbonne Paris Cite, CNRS UMR 860, Laboratoire 
      de Chimie et de Biochimie Pharmacologiques et Toxicologique, 45, rue des Saints 
      Peres, 75006 Paris, France.
AD  - CQM-Centro de Quimica da Madeira, Universidade da Madeira, 9020-105 Funchal, 
      Portugal.
FAU - Majoral, Jean-Pierre
AU  - Majoral JP
AD  - Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, BP 44099, 
      31077 Toulouse CEDEX 4, France.
AD  - Universite de Toulouse, UPS, INPT, 31077 Toulouse CEDEX 4, France.
FAU - Shen, Mingwu
AU  - Shen M
AUID- ORCID: 0000-0002-1065-0854
AD  - State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, 
      Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative 
      Medicine, College of Biological Science and Medical Engineering, Donghua 
      University, Shanghai 201620, P. R. China. mwshen@dhu.edu.cn.
FAU - Shi, Xiangyang
AU  - Shi X
AUID- ORCID: 0000-0001-6785-6645
AD  - State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, 
      Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative 
      Medicine, College of Biological Science and Medical Engineering, Donghua 
      University, Shanghai 201620, P. R. China. mwshen@dhu.edu.cn.
AD  - CQM-Centro de Quimica da Madeira, Universidade da Madeira, 9020-105 Funchal, 
      Portugal.
LA  - eng
PT  - Journal Article
DEP - 20230214
PL  - England
TA  - Biomater Sci
JT  - Biomaterials science
JID - 101593571
RN  - 0 (MicroRNAs)
RN  - 0 (Dendrimers)
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *MicroRNAs/metabolism
MH  - *Dendrimers/metabolism
MH  - *Acute Lung Injury/drug therapy/genetics/metabolism
MH  - Macrophages/metabolism
MH  - Anti-Inflammatory Agents/chemistry
EDAT- 2023/01/07 06:00
MHDA- 2023/02/16 06:00
CRDT- 2023/01/06 09:22
PHST- 2023/01/07 06:00 [pubmed]
PHST- 2023/02/16 06:00 [medline]
PHST- 2023/01/06 09:22 [entrez]
AID - 10.1039/d2bm01807a [doi]
PST - epublish
SO  - Biomater Sci. 2023 Feb 14;11(4):1530-1539. doi: 10.1039/d2bm01807a.