PMID- 36608569 OWN - NLM STAT- MEDLINE DCOM- 20230118 LR - 20230118 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 250 DP - 2023 Jan 15 TI - Independent, combine and interactive effects of heavy metal exposure on dyslipidemia biomarkers: A cross-sectional study in northeastern China. PG - 114494 LID - S0147-6513(22)01334-3 [pii] LID - 10.1016/j.ecoenv.2022.114494 [doi] AB - Dyslipidemia is a common disease in the older population and represents a considerable disease burden worldwide. Epidemiological and experimental studies have indicated associations between heavy metal exposure and dyslipidemia; few studies have investigated the effects of heavy metal mixture and interactions between metals on dyslipidemia. We recruited 1121 participants living in heavy metal-contaminated and control areas in northeast China from a cross-sectional survey (2017-2019). Urinary metals including chromium (Cr), cadmium (Cd), lead (Pb), and manganese (Mn) and dyslipidemia biomarkers, namely triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels, were measured. The generalized linear model (GLM) was used to explore the association of a single metal with dyslipidemia biomarkers. Bayesian kernel machine regression (BKMR) and multivariable linear regression were performed to explore the overall effect of metal mixture and the interaction between metals on dyslipidemia. Heavy metal mixture was positively associated with LDL-C, TC, and TG and negatively with HDL-C. In multivariable linear regression, Pb and Cd exhibited a synergistic association with LDL-C in the participants without hyperlipemia. Mn-Cd and Pb-Cr also showed a synergistic association with increasing the level of LDL-C in subjects without hyperlipemia. Cd-Cr showed an antagonistic association with HDL-C, respectively. Cr-Mn exhibited an antagonistic association with decreased HDL-C and TG levels. No significant interaction was noted among the three metals. Our study indicated that exposure to heavy metals is associated with dyslipidemia biomarkers and the presence of potential synergistic or antagonistic interactions between the heavy metals. CI - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Zhao, Meiduo AU - Zhao M AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. FAU - Yin, Guohuan AU - Yin G AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China. FAU - Xu, Jing AU - Xu J AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. FAU - Ge, Xiaoyu AU - Ge X AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. FAU - Li, Ang AU - Li A AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. FAU - Mei, Yayuan AU - Mei Y AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. FAU - Wu, Jingtao AU - Wu J AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. FAU - Liu, Xiaolin AU - Liu X AD - Department of Epidemiology and Biostatistics, Jinzhou Medical University, Jinzhou 121001, Liaoning, China. FAU - Wei, Lanping AU - Wei L AD - Jinzhou Central Hospital, Jinzhou 121001, Liaoning, China. FAU - Xu, Qun AU - Xu Q AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. Electronic address: xuqun@ibms.cams.cn. LA - eng PT - Journal Article DEP - 20230104 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 RN - 00BH33GNGH (Cadmium) RN - 0 (Cholesterol, LDL) RN - 2P299V784P (Lead) RN - 0 (Metals, Heavy) RN - 42Z2K6ZL8P (Manganese) RN - 0R0008Q3JB (Chromium) RN - 0 (Triglycerides) RN - 0 (Cholesterol, HDL) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Cadmium/toxicity MH - Cholesterol, LDL MH - Bayes Theorem MH - Lead/toxicity MH - *Metals, Heavy/toxicity MH - Manganese MH - Chromium MH - Triglycerides MH - Cholesterol, HDL MH - *Dyslipidemias/chemically induced/epidemiology MH - China OTO - NOTNLM OT - BKMR OT - Dyslipidemia OT - Heavy metal OT - Interaction OT - Marginal effect COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/01/07 06:00 MHDA- 2023/01/19 06:00 CRDT- 2023/01/06 18:17 PHST- 2022/09/16 00:00 [received] PHST- 2022/12/27 00:00 [revised] PHST- 2022/12/29 00:00 [accepted] PHST- 2023/01/07 06:00 [pubmed] PHST- 2023/01/19 06:00 [medline] PHST- 2023/01/06 18:17 [entrez] AID - S0147-6513(22)01334-3 [pii] AID - 10.1016/j.ecoenv.2022.114494 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2023 Jan 15;250:114494. doi: 10.1016/j.ecoenv.2022.114494. Epub 2023 Jan 4.