PMID- 36609773
OWN - NLM
STAT- MEDLINE
DCOM- 20230614
LR  - 20230614
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 46
IP  - 7
DP  - 2023 Jul
TI  - Gender-specific effects of capsiate supplementation on body weight and bone 
      mineral density: a randomized, double-blind, placebo-controlled study in slightly 
      overweight women.
PG  - 1415-1422
LID - 10.1007/s40618-022-01999-w [doi]
AB  - INTRODUCTION: Overweight and obesity are highly prevalent conditions associated 
      with premature morbidity and mortality worldwide. Capsiate, a nonpungent analogue 
      of capsaicin, binds to TRP vanilloid 1 (TRPV1) receptor, which is involved in 
      adipogenesis, and could be effective as a weight-lowering agent. METHODS: 
      Eighteen slightly overweight women were enrolled in this randomized, 
      double-blind, placebo-controlled study. Nine patients were included in the 
      capsiate intervention group and received 9 mg/day of capsinoids and 9 patients 
      received placebo for 8 weeks. All patients underwent weight and waist 
      circumference assessment before and after treatment. Body composition and bone 
      mineral density (BMD) were also detected by dual-energy X-ray absorptiometry 
      (DXA). RESULTS: Fourteen patients completed the study. The treatment with 
      capsiate or placebo for 8 weeks was not associated with significant changes in 
      weight or waist circumference. After treatment, there was a significant 
      improvement in BMD values measured at the spine in the capsiate group (1.158 vs 
      1.106 g/cm(2), + 4.7%; p = 0.04), but not in the group treated with placebo. 
      Similarly, the capsiate group showed a 9.1% increase (p = 0.05) in the adipose 
      tissue and an 8.5% decrease in lean mass measured at the supraclavicular level, 
      whereas these changes were not statistically significant in the placebo group. 
      CONCLUSIONS: Treatment with capsiate for 8 weeks led to negligible changes in 
      body weight in a small sample of slightly overweight women, but our findings 
      suggest a potential effect of capsaicin on bone metabolism in humans.
CI  - (c) 2023. The Author(s), under exclusive licence to Italian Society of 
      Endocrinology (SIE).
FAU - Salvio, G
AU  - Salvio G
AD  - Division of Endocrinology, Department of Clinical and Molecular Sciences, Marche 
      Polytechnic University, Ancona, Italy.
FAU - Petrelli, M
AU  - Petrelli M
AD  - Division of Endocrinology, Department of Clinical and Molecular Sciences, Marche 
      Polytechnic University, Ancona, Italy.
FAU - Paolini, S
AU  - Paolini S
AD  - Division of Endocrinology, Department of Clinical and Molecular Sciences, Marche 
      Polytechnic University, Ancona, Italy.
FAU - Baldini, V
AU  - Baldini V
AD  - Division of Endocrinology, Department of Clinical and Molecular Sciences, Marche 
      Polytechnic University, Ancona, Italy.
FAU - Sbaffi, C
AU  - Sbaffi C
AD  - Division of Endocrinology, Department of Clinical and Molecular Sciences, Marche 
      Polytechnic University, Ancona, Italy.
FAU - Basili, S
AU  - Basili S
AD  - Division of Endocrinology, Department of Clinical and Molecular Sciences, Marche 
      Polytechnic University, Ancona, Italy.
FAU - Giordano, A
AU  - Giordano A
AD  - Center of Obesity, Department of Experimental and Clinical Medicine, Marche 
      Polytechnic University, Ancona, Italy.
FAU - Balercia, G
AU  - Balercia G
AD  - Division of Endocrinology, Department of Clinical and Molecular Sciences, Marche 
      Polytechnic University, Ancona, Italy.
FAU - Cinti, S
AU  - Cinti S
AD  - Center of Obesity, Department of Experimental and Clinical Medicine, Marche 
      Polytechnic University, Ancona, Italy. saverio.cinti@icloud.com.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230106
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - PX8I7HG5I3 (capsiate)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Capsaicin/pharmacology
MH  - *Bone Density
MH  - Overweight
MH  - Dietary Supplements
MH  - Double-Blind Method
OTO - NOTNLM
OT  - Brown adipose tissue
OT  - Capsaicin
OT  - Capsinoids
OT  - Osteoporosis
OT  - Spices
EDAT- 2023/01/08 06:00
MHDA- 2023/06/14 06:42
CRDT- 2023/01/07 16:51
PHST- 2022/09/16 00:00 [received]
PHST- 2022/12/20 00:00 [accepted]
PHST- 2023/06/14 06:42 [medline]
PHST- 2023/01/08 06:00 [pubmed]
PHST- 2023/01/07 16:51 [entrez]
AID - 10.1007/s40618-022-01999-w [pii]
AID - 10.1007/s40618-022-01999-w [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2023 Jul;46(7):1415-1422. doi: 10.1007/s40618-022-01999-w. 
      Epub 2023 Jan 6.