PMID- 36610141
OWN - NLM
STAT- MEDLINE
DCOM- 20230112
LR  - 20230112
IS  - 1618-095X (Electronic)
IS  - 0944-7113 (Linking)
VI  - 109
DP  - 2023 Jan
TI  - The role of traditional herbal medicine for ischemic stroke: from bench to 
      clinic-A critical review.
PG  - 154609
LID - S0944-7113(22)00697-3 [pii]
LID - 10.1016/j.phymed.2022.154609 [doi]
AB  - BACKGROUND: Ischemic stroke (IS) is a leading cause of death and severe long-term 
      disability worldwide. Over the past few decades, considerable progress has been 
      made in anti-ischemic therapies. However, IS remains a tremendous challenge, with 
      favourable clinical outcomes being generally difficult to achieve from candidate 
      drugs in preclinical phase testing. Traditional herbal medicine (THM) has been 
      used to treat stroke for over 2,000 years in China. In modern times, THM as an 
      alternative and complementary therapy have been prescribed in other Asian 
      countries and have gained increasing attention for their therapeutic effects. 
      These millennia of clinical experience allow THM to be a promising avenue for 
      improving clinical efficacy and accelerating drug discovery. PURPOSE: To 
      summarise the clinical evidence and potential mechanisms of THMs in IS. METHODS: 
      A comprehensive literature search was conducted in seven electronic databases, 
      including PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, the 
      Chinese National Knowledge Infrastructure, the VIP Information Database, the 
      Chinese Biomedical Literature Database, and the Wanfang Database, from inception 
      to 17 June 2022 to examine the efficacy and safety of THM for IS, and to 
      investigate experimental studies regarding potential mechanisms. RESULTS: THM is 
      widely prescribed for IS alone or as adjuvant therapy. In clinical trials, THM is 
      generally administered within 72 h of stroke onset and are continuously 
      prescribed for over 3 months. Compared with Western medicine (WM), THM combined 
      with routine WM can significantly improve neurological function defect scores, 
      promote clinical total effective rate, and accelerate the recovery time of stroke 
      with fewer adverse effects (AEs). These effects can be attributed to multiple 
      mechanisms, mainly anti-inflammation, antioxidative stress, anti-apoptosis, brain 
      blood barrier (BBB) modulation, inhibition of platelet activation and thrombus 
      formation, and promotion of neurogenesis and angiogenesis. CONCLUSIONS: THM may 
      be a promising candidate for IS management to guide clinical applications and as 
      a reference for drug development.
CI  - Copyright (c) 2022 Elsevier GmbH. All rights reserved.
FAU - Hao, Dan-Li
AU  - Hao DL
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing 100700, China.
FAU - Li, Jia-Meng
AU  - Li JM
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing 100700, China.
FAU - Xie, Ran
AU  - Xie R
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing 100700, China.
FAU - Huo, Hai-Ru
AU  - Huo HR
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing 100700, China.
FAU - Xiong, Xing-Jiang
AU  - Xiong XJ
AD  - Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, 
      China. Electronic address: xiongxingjiangtcm@163.com.
FAU - Sui, Feng
AU  - Sui F
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing 100700, China. Electronic address: fsui@icmm.ac.cn.
FAU - Wang, Peng-Qian
AU  - Wang PQ
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing 100700, China. Electronic address: pengqian.wang@163.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221217
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Humans
MH  - *Drugs, Chinese Herbal/adverse effects
MH  - *Ischemic Stroke/drug therapy
MH  - *Complementary Therapies
MH  - Medicine, Traditional
MH  - *Stroke/drug therapy
MH  - Medicine, Chinese Traditional
OTO - NOTNLM
OT  - Clinical efficacy
OT  - Ischemic stroke
OT  - Pharmacological mechanisms
OT  - Traditional Chinese medicine
COIS- Declaration of Competing Interest The authors declare no conflict of interest.
EDAT- 2023/01/08 06:00
MHDA- 2023/01/13 06:00
CRDT- 2023/01/07 18:05
PHST- 2022/05/11 00:00 [received]
PHST- 2022/09/29 00:00 [revised]
PHST- 2022/12/16 00:00 [accepted]
PHST- 2023/01/08 06:00 [pubmed]
PHST- 2023/01/13 06:00 [medline]
PHST- 2023/01/07 18:05 [entrez]
AID - S0944-7113(22)00697-3 [pii]
AID - 10.1016/j.phymed.2022.154609 [doi]
PST - ppublish
SO  - Phytomedicine. 2023 Jan;109:154609. doi: 10.1016/j.phymed.2022.154609. Epub 2022 
      Dec 17.