PMID- 36610806
OWN - NLM
STAT- MEDLINE
DCOM- 20230324
LR  - 20230324
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 84
IP  - 3
DP  - 2023 Mar
TI  - Human leukocyte antigen association with azathioprine-induced drug 
      hypersensitivity reactions in patients with anti-neutrophil cytoplasmic antibody 
      associated vasculitis.
PG  - 196-198
LID - S0198-8859(22)00255-5 [pii]
LID - 10.1016/j.humimm.2022.12.006 [doi]
AB  - Azathioprine (AZA) drug hypersensitivity reaction (DHR) is an uncommon yet 
      potentially lethal condition that often goes unrecognised in patients with 
      anti-Neutrophil Cytoplasmic Antibody (ANCA) associated vasculitis (AAV). We 
      conducted a retrospective review of AAV patients on AZA maintenance therapy 
      (N = 35). Participants were categorised into those who had experienced AZA-DHR 
      (N = 15) and those who were AZA-tolerant (N = 20). Human leukocyte antigen (HLA) 
      typing was performed in both groups. The primary endpoint was identification of a 
      HLA gene association with AZA-DHR in the context of AAV. HLA-C*06:02, was solely 
      expressed in AZA-DHR patients (33.3 %), whilst no patient who tolerated AZA 
      carried this allele (0.0 %). This yielded a positive predictive value of 100 % 
      for HLA-C*06:02 in predicting AZA-DHR in AAV patients, negative predictive value 
      of 66.7 %, sensitivity of 33.3 % and specificity of 100 %. HLA-C*06:02 may 
      predict the development of AZA-DHR in patients with AAV and inform safer 
      therapeutic choice.
CI  - Crown Copyright (c) 2023. Published by Elsevier Inc. All rights reserved.
FAU - Salehi, Tania
AU  - Salehi T
AD  - Royal Adelaide Hospital, Adelaide, Australia.
FAU - Fleet, Adrian P
AU  - Fleet AP
AD  - South Australian Transplantation and Immunogenetics Laboratory (SATIS), 
      Australian Red Cross Lifeblood, Adelaide, Australia.
FAU - Hissaria, Pravin
AU  - Hissaria P
AD  - Royal Adelaide Hospital, Adelaide, Australia; The University of Adelaide, 
      Adelaide, Australia.
FAU - Carroll, Robert P
AU  - Carroll RP
AD  - Royal Adelaide Hospital, Adelaide, Australia; South Australian Transplantation 
      and Immunogenetics Laboratory (SATIS), Australian Red Cross Lifeblood, Adelaide, 
      Australia; The University of Adelaide, Adelaide, Australia.
FAU - Au Peh, Chen
AU  - Au Peh C
AD  - Royal Adelaide Hospital, Adelaide, Australia; The University of Adelaide, 
      Adelaide, Australia.
LA  - eng
PT  - Journal Article
DEP - 20230105
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - MRK240IY2L (Azathioprine)
RN  - 0 (Histocompatibility Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Humans
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/chemically 
      induced/drug therapy
MH  - Antibodies, Antineutrophil Cytoplasmic/therapeutic use
MH  - Azathioprine/adverse effects
MH  - *Drug Hypersensitivity/immunology
MH  - Histocompatibility Antigens
MH  - Histocompatibility Antigens Class II
MH  - *HLA Antigens/drug effects/metabolism
MH  - HLA-C Antigens
OTO - NOTNLM
OT  - ANCA vasculitis
OT  - Azathioprine hypersensitivity
OT  - HLA association
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/01/08 06:00
MHDA- 2023/03/04 06:00
CRDT- 2023/01/07 21:53
PHST- 2022/08/04 00:00 [received]
PHST- 2022/12/20 00:00 [revised]
PHST- 2022/12/29 00:00 [accepted]
PHST- 2023/01/08 06:00 [pubmed]
PHST- 2023/03/04 06:00 [medline]
PHST- 2023/01/07 21:53 [entrez]
AID - S0198-8859(22)00255-5 [pii]
AID - 10.1016/j.humimm.2022.12.006 [doi]
PST - ppublish
SO  - Hum Immunol. 2023 Mar;84(3):196-198. doi: 10.1016/j.humimm.2022.12.006. Epub 2023 
      Jan 5.