PMID- 36611047
OWN - NLM
STAT- MEDLINE
DCOM- 20230110
LR  - 20230224
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Jan 7
TI  - HBV genotype-dependent association of HLA variants with the serodecline of HBsAg 
      in chronic hepatitis B patients.
PG  - 359
LID - 10.1038/s41598-023-27570-y [doi]
LID - 359
AB  - Seroclearance of hepatitis B surface antigen (HBsAg) is regarded as the 
      functional cure for chronic hepatitis B (CHB). The relationship between human 
      leukocyte antigen (HLA) variants, hepatitis B virus genotype, and longitudinal 
      HBsAg serodecline remains to be explored. A total of 1735 HBeAg-seronegative CHB 
      patients with genotype B or C infection of the community-based REVEAL-HBV cohort 
      were genotyped for rs1710 (HLA-G) and rs2770 (HLA-B) using TaqMan assay. Cox 
      proportional hazard regression and generalized linear mixed models were used to 
      analyze the association of HLA genetic variants with the rate of HBsAg 
      seroclearance and longitudinal HBsAg serodecline. Rs1710 G allele was 
      differentially associated with the HBsAg seroclearance in genotype B [aRR (95% 
      CI) = 0.74 (0.56-0.98)] and genotype C [aRR (95%CI) = 1.43 (1.08-1.88)] 
      infection. Rs2770 G allele was associated with HBsAg seroclearance only in 
      genotype B infection [aRR (95% CI) = 0.69 (0.52-0.91)]. The alleles associated 
      with HBsAg seroclearance were significant predictors for the serodecline of HBsAg 
      levels in an HBV genotype-dependent manner (genotype B infection: rs1710, 
      P = 0.013; rs2770, P = 0.0081; genotype C infection: rs1710, P = 0.0452). Our 
      results suggest both spontaneous HBsAg seroclearance and serodecline are modified 
      by the interaction between HLA variants and HBV genotype.
CI  - (c) 2023. The Author(s).
FAU - Chu, Yu-Ju
AU  - Chu YJ
AD  - Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, 
      Taipei, Taiwan.
AD  - Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, 
      Taiwan.
FAU - Yang, Hwai-I
AU  - Yang HI
AD  - Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, 
      Taipei, Taiwan.
AD  - Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
AD  - Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
FAU - Hu, Hui-Han
AU  - Hu HH
AD  - Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, 
      Taipei, Taiwan.
AD  - School of Public Health, National Defense Medical Center, Taipei, Taiwan.
FAU - Liu, Jessica
AU  - Liu J
AD  - Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, 
      Taipei, Taiwan.
FAU - Lin, Yu-Ling
AU  - Lin YL
AD  - Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, 
      Taipei, Taiwan.
FAU - Chang, Chia-Ling
AU  - Chang CL
AD  - Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, 
      Taipei, Taiwan.
FAU - Luo, Wen-Sheng
AU  - Luo WS
AD  - Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, 
      Taipei, Taiwan.
FAU - Jen, Chin-Lan
AU  - Jen CL
AD  - Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, 
      Taipei, Taiwan.
FAU - Chen, Chien-Jen
AU  - Chen CJ
AD  - Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, 
      Taipei, Taiwan. chencj@gate.sinica.edu.tw.
AD  - College of Medicine, Fu-Jen Catholic University, New Taipei, Taiwan. 
      chencj@gate.sinica.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230107
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Hepatitis B Surface Antigens)
RN  - 0 (Hepatitis B e Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Histocompatibility Antigens)
RN  - 0 (HLA Antigens)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Humans
MH  - Hepatitis B Surface Antigens/genetics
MH  - *Hepatitis B, Chronic
MH  - Hepatitis B virus/genetics
MH  - Hepatitis B e Antigens/genetics
MH  - Genotype
MH  - Histocompatibility Antigens Class II/genetics
MH  - Histocompatibility Antigens
MH  - HLA Antigens
MH  - DNA, Viral/genetics
MH  - *Hepatitis B
PMC - PMC9825396
COIS- The authors declare no competing interests.
EDAT- 2023/01/08 06:00
MHDA- 2023/01/11 06:00
PMCR- 2023/01/07
CRDT- 2023/01/07 23:15
PHST- 2022/09/30 00:00 [received]
PHST- 2023/01/04 00:00 [accepted]
PHST- 2023/01/07 23:15 [entrez]
PHST- 2023/01/08 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2023/01/07 00:00 [pmc-release]
AID - 10.1038/s41598-023-27570-y [pii]
AID - 27570 [pii]
AID - 10.1038/s41598-023-27570-y [doi]
PST - epublish
SO  - Sci Rep. 2023 Jan 7;13(1):359. doi: 10.1038/s41598-023-27570-y.